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Soy pretzels vs. wheat pretzels: a surprising weapon against inflammation?

NCT ID NCT07650409

Symptom relief Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either soy or wheat pretzels and provide blood and urine samples to measure changes in inflammatory markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
soy soft pretzels
What this could lead to
If it works, this could point toward a simple dietary change to help lower chronic inflammation in people with obesity.
What could go wrong
This is a very small, early-stage trial with only 30 participants. The effect may be small or not meaningful, and results may not apply to women or older adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 49 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures, lifestyle considerations, and availability for the duration of the study * Males sex * 18 and 49 years of age * Height and weight or calculated BMI for: * Obese participants must be ≥ 30 kg/m\^2 * Non-obese (healthy) participants must be between 18.5 and 24.9 kg/m\^2 Exclusion Criteria: * Inability to comply with all study procedures, lifestyle considerations, and availability for the duration of the study * Known allergy or intolerance to soy, wheat, or any other ingredients in study intervention * Current or prior history of type 2 diabetes mellitus as defined by International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) E11 * Current or prior history of cancer (excluding non-melanoma skin cancers) * History of blood clotting disorders or adverse events relating to blood draws * Use of antibiotic regime lasting longer than one week within the last six months * Current enrollment in other research studies for weight loss * Actively trying to lose weight and/or use of medications for weight loss within the last three months * Strict veganism (no consumption of animal, fish, or egg products) * Heavy alcohol consumption (defined as consumption of \> 14 drinks/week on average) * Current or prior history of any condition that causes altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias * Regular usage of inflammation lowering medications which include but not limited to nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen, or anti-pyretic medications such as acetaminophen

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Conditions

The condition(s) this trial relates to.

cancer colorectal carcinoma colorectal neoplasm obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal carcinoma Obesity-related malignant neoplasm

Contacts and locations

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

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Other studies related to the condition(s) this trial covers.