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Genetic clues to childhood obesity: study seeks answers

NCT ID NCT06239064

Knowledge-focused Sponsor: Rolfs Consulting und Verwaltungs-GmbH (RCV) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or saliva sample for genetic testing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants at risk for a syndromic or a monogenic genetic obesity, incl. participants clinically diagnosed with Bardet-Biedl-Syndrome (BBS)

Ages

2 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Informed consent is obtained from the participant/parent/legal guardian * The participant is 2 years of age or older For a participant between 2 and 18 years of age: * The participant has and had a body weight more than 97th percentile before the age of 6 * The participant has one or more of the following symptoms: rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism For a participant who is 18 years of age or older: * The participant has BMI ≥ 30 kg/m2 * The participant had a body weight more than 97th percentile before the age of 6 years * The participant has rod/cone dystrophy * The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study Exclusion criteria: \- Not fulfilling the inclusion criteria

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Conditions

The condition(s) this trial relates to.

Bardet-Biedl syndrome Cognitive Dysfunction Hyperphagia obesity disorder obesity due to pro-opiomelanocortin deficiency Pediatric Obesity polydactyly retinal disorder syndactyly

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bardet Biedl syndrome Cognitive impairment Hyperphagia Obesity, childhood Polydactyly Pomc deficiency Retinopathy Syndactyly

Contacts and locations

Locations

  • Cellitinnen-Krankenkaus St. Franziskus

    Cologne, 50825, Germany

  • Dietrich-Bonhoeffer-Klinikum

    Neubrandenburg, 17036, Germany

  • Dreifaltigkeits-Krankenhaus Wesseling

    Wesseling, 50389, Germany

  • Elblandklinikum Riesa

    Riesa, 01589, Germany

  • GPR Klinikum Rüsselsheim

    Rüsselsheim am Main, 65428, Germany

  • Hausarztpraxis Rahman & Detho

    Obertshausen, 63179, Germany

  • Hormonzentrum Heidelberg

    Heidelberg, 69115, Germany

  • KJF Klinik Josefinum

    Augsburg, 86154, Germany

  • Katholisches Kinderkrankenhaus WILHELMSTIFT

    Hamburg, 22149, Germany

  • Kinder- und Jugendarztpraxis Nebras Mohammad

    Iserlohn, 58636, Germany

  • Kinder- und Jugendarztpraxis Sulaiman Al Sawaf

    Nettetal, 41334, Germany

  • Kinder- und Jugendkrankenhaus Auf der Bult

    Hanover, 30173, Germany

  • Kinder- und Jugendpraxis Dogan

    Stuttgart, 70178, Germany

  • Kinderärzte am Leo

    Pforzheim, 75172, Germany

  • Klinikum Bielefeld Mitte

    Bielefeld, 33604, Germany

  • Klinikum Ernst von Bergmann

    Potsdam, 14467, Germany

  • Klinikum Frankfurt (Oder)

    Frankfurt (Oder), 15236, Germany

  • Praxis für Endokrinologie Dr. Daniel Pfaff

    Bückeburg, 31675, Germany

  • Praxis für Kinder- und Jugendmedizin Dr. med. Tabea Tippelt

    Velbert, 42551, Germany

  • Praxis für Kinder- und Jugendmedizin Seyfullah Gökce

    Wiesbaden, 65185, Germany

  • SRH Wald-Klinikum Gera

    Gera, 07548, Germany

  • SRH Zentralklinikum Suhl GmbH

    Suhl, 98527, Germany

  • Sana Klinikum Offenbach

    Offenbach, 63069, Germany

  • Sozialpädiatrisches Zentrum Leipzig

    Leipzig, 04129, Germany

  • Städtische Kliniken Mönchengladbach - Elisabeth-Krankenhaus Rheydt

    Mönchengladbach, 41239, Germany

  • Universitätsklinikum Aachen (RWTH)

    Aachen, 52074, Germany

  • Universitätsklinikum Augsburg - Klinik für Kinder- und Jugendmedizin

    Augsburg, 86156, Germany

  • Universitätsklinikum Bonn

    Bonn, 53127, Germany

  • Universitätsklinikum Freiburg

    Bad Krozingen, 79189, Germany

  • Universitätsklinikum Jena

    Jena, 07747, Germany

  • Universitätsklinikum Schleswig-Holstein - Campus Kiel

    Kiel, 24105, Germany

  • Universitätsklinikum Würzburg - Medizinische Klinik und Poliklinik I

    Würzburg, 97080, Germany

  • Universitätsmedizin Essen

    Essen, 45147, Germany

  • Universitätsmedizin Greifswald - Klinik und Poliklinik für Innere Medizin A

    Greifswald, 17475, Germany

  • Universitätsmedizin Göttingen - Klinik für Kinder- und Jugendmedizin

    Göttingen, 37075, Germany

  • Universitätsmedizin Mannheim - Augenklinik

    Mannheim, 68167, Germany

  • WolfartKlinik

    Gräfelfing, 82166, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.