New anesthesia combo may cut opioid use after weight loss surgery
NCT ID NCT07246447
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a mix of ketamine and dexmedetomidine (ketodex) can reduce the need for strong painkillers after laparoscopic sleeve gastrectomy in obese patients. Eight adults with a BMI over 35 are randomly assigned to receive either ketodex or standard opioid-based anesthesia. The main goal is to measure total pain medication use in the first 24 hours after surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 8 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (\>18 years) undergoing Elective Bariatric Surgery . * American Society of Anesthesiologists physical status class II or III . * body mass index (BMI) \> 35 kg/m2 . Exclusion Criteria: * • Refusal to participate . * Any sensitivity or contraindication to ketamine or dexmedotomidine . * Pregnancy or breast feeding . * Patients with significant renal impairment . * Any patient on regular intake of beta blockers or calcium channel blockers . * CNS disorders eg: seizures , raised intra cranial tension . * Chronic opioid use. * Obese patients with STOP bang score more than 5 .
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cairo university hospitals
Cairo, Manial, 11965, Egypt
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Other studies related to the condition(s) this trial covers.
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