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Processed vs. natural: which diet wins for your heart?

NCT ID NCT07252037

Knowledge-focused Sponsor: USDA Grand Forks Human Nutrition Research Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference. The goal is to understand food processing's impact, not to treat a disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI 18.5-34.9 kg/m2 * Systolic \<139 mm Hg and Diastolic \<90 mm Hg * Able to understand and sign the consent form * Have own transportation to the Grand Forks Human Nutrition Research Center * Not allergic to study foods or unwilling to eat them * Willing to comply with study demands * Able to read and understand English Exclusion Criteria: * Taking statins or medication to lower blood pressure, * Taking anti-inflammatory or anti-diabetes medications * Pregnant, lactating, or planning to become pregnant * Diagnosed with an eating disorder * Taking weight loss medications * Smoke or use other tobacco products, including e-cigarettes * Have overt hypothyroidism * Diagnosed with cancer * Exercise more than 30 minutes per day 2 or more days per week * Allergic to study foods * Express unwillingness to consume study foods at the screening appointment

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Class I obesity Overweight/obesity

Contacts and locations

Locations

  • USDA Grand Forks Human Nutrition Research Center

    Grand Forks, North Dakota, 58203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.