New obesity drug VK2735 enters final testing phase

NCT ID NCT07104500

Disease control Sponsor: Viking Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called VK2735, given as a weekly injection, to help people with obesity or overweight lose weight. About 4500 adults without diabetes will receive either the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose and if the drug is safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 4,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years of age at the time of signing the informed consent 2. Body mass index (BMI) ≥30 kg/m2 OR ≥27 kg/m2 with at least one weight-related co- morbid condition (treated or untreated) * Weight-related co-morbid conditions include hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease * Cardiovascular disease includes, for example, ischemic cardiovascular disease, New York Heart Association (NYHA) Functional Class I-III heart failure * BMI calculated at the Screening visit will be used to determine eligibility Exclusion Criteria: 1. History of or current clinically significant medical disorder that, in the opinion of the Investigator, does not support study participation 2. Self-reported body weight change of 5% or more within 3 months of screening 3. Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed \>1 year prior to screening) 4. Have or plan to have endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months prior to screening (such as, mucosa ablation, gastric artery embolization, intragastric balloon, duodenal-jejunal endoluminal line) 5. Current or past diagnosis of diabetes mellitus (including type 1, type 2, except gestational diabetes) 6. Treatment with glucose-lowering agent(s) within 90 days before screening 7. Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) 8. History of acute or chronic pancreatitis

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weight loss

Contacts and locations

Locations

Viking Clinical Site #1001

Methuen, Massachusetts, 01844, United States
Viking Clinical Site #1002

Ogden, Utah, 84405, United States
Viking Clinical Site #1003

Cooper City, Florida, 33024, United States
Viking Clinical Site #1004

Knoxville, Tennessee, 37909, United States
Viking Clinical Site #1005

Chandler, Arizona, 85210, United States
Viking Clinical Site #1006

Chicago, Illinois, 60607, United States
Viking Clinical Site #1007

Austin, Texas, 78705, United States
Viking Clinical Site #1008

Nashville, Tennessee, 37203, United States
Viking Clinical Site #1009

Louisville, Kentucky, 40213, United States
Viking Clinical Site #1010

Butte, Montana, 59701, United States
Viking Clinical Site #1011

Port Orange, Florida, 32127, United States
Viking Clinical Site #1012

Ocoee, Florida, 34761, United States
Viking Clinical Site #1013

Clearwater, Florida, 33756, United States
Viking Clinical Site #1014

Lake Forest, California, 92630, United States
Viking Clinical Site #1016

Kansas City, Missouri, 64131, United States
Viking Clinical Site #1017

Flagstaff, Arizona, 86001, United States
Viking Clinical Site #1018

Peoria, Arizona, 85381, United States
Viking Clinical Site #1019

Tucson, Arizona, 85711, United States
Viking Clinical Site #1020

Metairie, Louisiana, 70006, United States
Viking Clinical Site #1021

The Bronx, New York, 10455, United States
Viking Clinical Site #1022

West Des Moines, Iowa, 50266, United States
Viking Clinical Site #1023

North Charleston, South Carolina, 29405, United States
Viking Clinical Site #1024

St. George, Utah, 84790, United States
Viking Clinical Site #1025

Woodstock, Georgia, 30189, United States
Viking Clinical Site #1026

Greensboro, North Carolina, 27410, United States
Viking Clinical Site #1027

Fargo, North Dakota, 58104, United States
Viking Clinical Site #1028

Greenville, South Carolina, 29607, United States
Viking Clinical Site #1029

Albuquerque, New Mexico, 87109, United States
Viking Clinical Site #1030

Columbus, Georgia, 31904, United States
Viking Clinical Site #1031

City of Saint Peters, Missouri, 63303, United States
Viking Clinical Site #1032

Westfield, New York, 14787, United States
Viking Clinical Site #1034

Reno, Nevada, 89511, United States
Viking Clinical Site #1035

Las Vegas, Nevada, 89148, United States
Viking Clinical Site #1036

Little Rock, Arkansas, 72211, United States
Viking Clinical Site #1037

Birmingham, Alabama, 35235, United States
Viking Clinical Site #1038

Ypsilanti, Michigan, 48197, United States
Viking Clinical Site #1039

Sandy City, Utah, 84094, United States
Viking Clinical Site #1040

Lexington, Kentucky, 40513, United States
Viking Clinical Site #1041

Spokane, Washington, 99218, United States
Viking Clinical Site #1042

East Syracuse, New York, 13057, United States
Viking Clinical Site #1043

Cincinnati, Ohio, 45219, United States
Viking Clinical Site #1044

Cleveland, Ohio, 44122, United States
Viking Clinical Site #1045

East Greenwich, Rhode Island, 02818, United States
Viking Clinical Site #1046

Houston, Texas, 77040, United States
Viking Clinical Site #1047

Abilene, Texas, 79606, United States
Viking Clinical Site #1048

Dallas, Texas, 75235, United States
Viking Clinical Site #1049

Dallas, Texas, 75230, United States
Viking Clinical Site #1050

Long Beach, California, 90815, United States
Viking Clinical Site #1051

Lincoln, California, 95648, United States
Viking Clinical Site #1052

Spring Valley, California, 91978, United States
Viking Clinical Site #1053

Montclair, California, 91763, United States
Viking Clinical Site #1054

Huntington Park, California, 90255, United States
Viking Clinical Site #1055

Los Angeles, California, 90057, United States
Viking Clinical Site #1056

Palmetto Bay, Florida, 33157, United States
Viking Clinical Site #1057

West Palm Beach, Florida, 33407, United States
Viking Clinical Site #1058

Jacksonville, Florida, 32216, United States
Viking Clinical Site #1059

New Port Richey, Florida, 34652, United States
Viking Clinical Site #1060

Lakewood Rch, Florida, 34211, United States
Viking Clinical Site #1061

Morehead City, North Carolina, 28857, United States
Viking Clinical Site #1062

Honolulu, Hawaii, 96814, United States
Viking Clinical Site #1063

Austin, Texas, 78131, United States
Viking Clinical Site #1064

Birmingham, Alabama, 35249, United States
Viking Clinical Site #1065

Lebanon, New Hampshire, 03756, United States
Viking Clinical Site #1066

Rockville, Maryland, 20854, United States
Viking Clinical Site #1067

Van Nuys, California, 91405, United States
Viking Clinical Site #1068

Panorama City, California, 91402, United States
Viking Clinical Site #1069

Lexington, Kentucky, 40509, United States
Viking Clinical Site #1070

Escondido, California, 92025, United States
Viking Clinical Site #1071

Chula Vista, California, 91911, United States
Viking Clinical Site #1072

Renton, Washington, 98057, United States
Viking Clinical Site #1073

San Antonio, Texas, 78229, United States
Viking Clinical Site #1074

Cincinnati, Ohio, 45242, United States
Viking Clinical Site #1075

Omaha, Nebraska, 68134, United States
Viking Clinical Site #1076

Lakeland, Florida, 33803, United States
Viking Clinical Site #1077

Lampasas, Texas, 76550, United States
Viking Clinical Site #1078

Manteca, California, 95336, United States
Viking Clinical Site #1079

Walnut Creek, California, 94598, United States
Viking Clinical Site #1080

Meridian, Idaho, 83642, United States
Viking Clinical Site #1081

Mobile, Alabama, 36608, United States
Viking Clinical Site #1082

Suffolk, Virginia, 23435, United States
Viking Clinical Site #1083

Fort Myers, Florida, 33912, United States
Viking Clinical Site #1085

San Antonio, Texas, 78222, United States
Viking Clinical Site #1086

San Juan, 00927, Puerto Rico
Viking Clinical Site #1087

Monroe, Louisiana, 71201, United States
Viking Clinical Site #1088

Albany, New York, 12205, United States
Viking Clinical Site #1089

Columbus, Ohio, 43215, United States
Viking Clinical Site #1090

Chicago, Illinois, 60640, United States
Viking Clinical Site #1091

Bellaire, Texas, 77401, United States
Viking Clinical Site #1092

Salt Lake City, Utah, 84107, United States
Viking Clinical Site #1093

Savannah, Georgia, 31406, United States
Viking Clinical Site #1094

Chevy Chase, Maryland, 20815, United States
Viking Clinical Site #1095

Marlton, New Jersey, 08009, United States
Viking Clinical Site #1096

Hartsdale, New York, 10530, United States
Viking Clinical Site #1097

Portland, Oregon, 97202, United States
Viking Clinical Site #1098

Arlington, Virginia, 22205, United States
Viking Clinical Site #1099

Wichita, Kansas, 67207, United States
Viking Clinical Site #1101

Waco, Texas, 76710, United States
Viking Clinical Site #1102

Medford, Oregon, 97504, United States
Viking Clinical Site #1103

Boston, Massachusetts, 02114, United States
Viking Clinical Site #1104

Santa Maria, California, 93458, United States
Viking Clinical Site #1106

Lafayette, Louisiana, 70508, United States
Viking Clinical Site #1107

Delray Beach, Florida, 33445, United States
Viking Clinical Site #1108

St Louis, Missouri, 63108, United States
Viking Clinical Site #1109

Tustin, California, 92780, United States
Viking Clinical Site #1110

Morehead City, North Carolina, 28557, United States
Viking Clinical Site #1111

Frisco, Texas, 75033, United States
Viking Clinical Site #1112

DeLand, Florida, 32720, United States
Viking Clinical Site #1113

Norman, Oklahoma, 73069, United States
Viking Clinical Site #1116

Atlanta, Georgia, 30329, United States
Viking Clinical Site #1117

Miami, Florida, 33122, United States
Viking Clinical Site #1118

Baton Rouge, Louisiana, 70808, United States
Viking Clinical Site #1119

Denver, Colorado, 80210, United States
Viking Clinical Site #1120

Rincon, Georgia, 31326, United States
Viking Clinical Site #1121

Clearwater, Florida, 33761, United States
Viking Clinical Site #1122

Durham, North Carolina, 27701, United States
Viking Clinical Site #1123

Washington D.C., District of Columbia, 20036, United States
Viking Clinical Site #1124

Brownsville, Texas, 78526, United States
Viking Clinical Site #1125

Springfield, Missouri, 65807, United States
Viking Clinical Site #1126

Portland, Oregon, 97210, United States
Viking Clinical Site #1127

Valparaiso, Indiana, 46383, United States
Viking Clinical Site #1128

Huntsville, Alabama, 35801, United States
Viking Clinical Site #1129

Lemon Grove, California, 91945, United States
Viking Clinical Site #1130

Mayagüez, 00680, Puerto Rico
Viking Clinical Site #1131

San Diego, California, 92103, United States
Viking Clinical Site #1132

Rolling Hills Estates, California, 90274, United States
Viking Clinical Site #1133

New York, New York, 10036, United States
Viking Clinical Site #1134

Myrtle Beach, South Carolina, 29572, United States
Viking Clinical Site #1135

Scottsdale, Arizona, 85260, United States
Viking Clinical Site #1136

Needham, Massachusetts, 02492, United States
Viking Clinical Site #1137

Tulsa, Oklahoma, 74133, United States
Viking Clinical Site #1138

Westmont, Illinois, 60559, United States
Viking Clinical Site #1139

Baton Rouge, Louisiana, 70809, United States
Viking Clinical Site #1140

Gulfport, Mississippi, 39503, United States
Viking Clinical Site #1141

Charlotte, North Carolina, 28250, United States
Viking Clinical Site #1142

New York, New York, 10065, United States
Viking Clinical Site #1143

San Antonio, Texas, 78215, United States
Viking Clinical Site #1144

Fayetteville, North Carolina, 28304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.