Can a 60-year-old diet pill work for years? new study aims to find out.
NCT ID NCT05176626
First seen Apr 25, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This study tests whether the weight-loss drug phentermine, currently approved for only 12 weeks, can be safely used for up to 2 years. About 870 adults with obesity will take phentermine and receive online lifestyle coaching. Researchers will track weight loss, blood pressure, and other health measures to see if long-term use is effective and safe.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Atrium Health Wake Forest Baptist Weight Management Center
Winston-Salem, North Carolina, 27104, United States
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HealthPartners Institute
Saint Louis Park, Minnesota, 55416, United States
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Kaiser Permanente Southern California
Los Angeles, California, 90034, United States
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UT Center for Obesity Medicine and Metabolic Performance
Bellaire, Texas, 77401, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
phentermine
What this could lead to
If successful, this could show that phentermine is safe and effective for long-term weight management, supporting its use beyond the current 12-week limit.
What could go wrong
This is a Phase 4 trial, but phentermine has known risks like increased blood pressure and heart rate. Long-term safety data are still limited, and weight loss may not be sustained in all participants.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.