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New obesity drug cocktail aims to melt fat, not muscle

NCT ID NCT06299098

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 4 times

Summary

This Phase 2 trial tests two experimental drugs, trevogrumab and garetosmab, added to the weight-loss drug semaglutide (Wegovy) in about 1,000 people with obesity. The goal is to see if the combination improves weight loss and body composition (more fat loss, less muscle loss) compared to semaglutide alone. The study also checks safety and how the drugs move through the body.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
trevogrumab, garetosmab, and semaglutide
What this could lead to
If successful, this combination could lead to a more effective obesity treatment that helps people lose more fat while preserving muscle mass.
What could go wrong
This is an early Phase 2 trial, so results are not yet proven. The drugs may cause side effects, and the added benefit over semaglutide alone is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

1,005 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria Part A 1. Male or female participants age ≥18 to ≤55 years of age at the time of screening 2. BMI ≥18 and ≤32 kg/m2, at the screening visit Part B and Part C 3. Male or female participants ≥18 to ≤80 years of age at the time of screening 4. BMI ≥30 kg/m2, at the screening visit 5. History of 1 or more self-reported unsuccessful dietary attempts to lose weight Key Exclusion Criteria 1. History of diabetes (Type 2 or Type 1). History of gestational diabetes is permitted 2. Previous bariatric surgery or planned bariatric surgery 3. History of hypertrophic cardiomyopathy 4. Abnormal electrocardiogram (ECG) findings at screening that meet Cornell voltage criteria for left ventricular hypertrophy 5. Any malignancy in the past 5 years prior to screening (except for nonmelanoma skin cancer that has been resected with no evidence of metastatic disease for 3 years prior to screening) 6. History of poorly controlled hypertension, as defined in the protocol 7. Have a history of any other condition (such as known drug abuse, alcohol abuse, diagnosed eating disorder, or a severe mental illness) that, in the opinion of the investigator, may preclude the participant from following and completing the protocol 8. Have history of use of marijuana/tetrahydrocannabinol (THC) within 90 days prior to Visit 1 of enrollment and are unwilling to abstain from marijuana/THC use during the trial 9. Has a history of any neuromuscular disorder (eg, multiple sclerosis, myasthenia gravis, myopathy, peripheral neuropathy, etc) Note: Other protocol-defined Inclusion/ Exclusion Criteria apply

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • AMR Norman

    Norman, Oklahoma, 73069, United States

  • Accellacare Clinical Research, Raleigh Medical Group

    Raleigh, North Carolina, 27609, United States

  • Accellacare of Piedmont, Piedmont Healthcare

    Statesville, North Carolina, 28625, United States

  • Accellacare of Salisbury

    Salisbury, North Carolina, 28144, United States

  • Acclaim Clinical Research

    San Diego, California, 92120, United States

  • Altoona Center for Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Anaheim Clinical Trials

    Anaheim, California, 92801, United States

  • Balanced Life Health Care Solutions

    Lawrenceville, Georgia, 30046, United States

  • Center for Advanced Research and Education

    Gainesville, Georgia, 30501, United States

  • Charlottesville Medical Research

    Charlottesville, Virginia, 22911, United States

  • Chattanooga Medical Research

    Chattanooga, Tennessee, 37412, United States

  • Clinical Research of Central Florida - Bond Clinic

    Winter Haven, Florida, 33880, United States

  • Clinical Research of West Florida, Inc.

    Tampa, Florida, 33606, United States

  • Clinvest Research

    Springfield, Missouri, 65807, United States

  • Consano Clinical Research

    Shavano Park, Texas, 78231, United States

  • Cotton O'Neil Clinical Research Center

    Topeka, Kansas, 66606, United States

  • Cullman Clinical Trials

    Cullman, Alabama, 35055, United States

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Elite Clinical Trials LLLP

    Blackfoot, Idaho, 83221, United States

  • Foothills Research Center Cct Research

    Phoenix, Arizona, 85044, United States

  • Fundacion de Investigacion (FDI) Clinical Research

    San Juan, 00927, Puerto Rico

  • Hassman Research Institute

    Berlin, New Jersey, 08009, United States

  • Health Research of Hampton Roads, Inc.

    Newport News, Virginia, 23606, United States

  • IMA Clinical Research Monroe - Armand

    Monroe, Louisiana, 71201, United States

  • IMA Clinical Research St. Petersburg

    St. Petersburg, Florida, 33709, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Javara Incorporated at Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Jefferson City Medical Group

    Jefferson City, Missouri, 65109, United States

  • L-MARC Research Center

    Louisville, Kentucky, 40213, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medresearch Inc

    El Paso, Texas, 79902, United States

  • Mercury Street Medical Group, PLLC

    Butte, Montana, 59701, United States

  • Metabolic Institute of America

    Tarzana, California, 91356, United States

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Northern California Research

    Sacramento, California, 95821, United States

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi, 38654, United States

  • PMG Research of Charleston

    Mt. Pleasant, South Carolina, 29464, United States

  • PMG Research of Knoxville - Emory Road

    Knoxville, Tennessee, 37938, United States

  • PMG Research of Knoxville - Merchant Drive

    Knoxville, Tennessee, 37912, United States

  • PMG Research of Winston-Salem, LLC

    Winston-Salem, North Carolina, 27103, United States

  • PRCCI Clinical Research Center

    San Juan, 00927, Puerto Rico

  • Pinnacle Research Group

    Anniston, Alabama, 36207, United States

  • Pmg Research of Bristol

    Bristol, Tennessee, 37620, United States

  • Pmg Research of Wilmington Llc

    Wilmington, North Carolina, 28401, United States

  • Prairie Education and Research Cooperative (PERC)

    Springfield, Illinois, 62701, United States

  • Precision Clinical Research, LLC

    Sunrise, Florida, 33351, United States

  • Prime Health and Wellness Clinic

    Fayette, Mississippi, 39069, United States

  • ProSciento

    Chula Vista, California, 91911, United States

  • Sky Integrative Medical Center Skycrng

    Ridgeland, Mississippi, 39157, United States

  • Southwest General Healthcare Center

    Fort Myers, Florida, 33907, United States

  • Tandem Clinical Research GI, LLC

    Marrero, Louisiana, 70072, United States

  • The South Bend Clinic Center for Research

    South Bend, Indiana, 46617, United States

  • Tribe Clinical Research Llc

    Greenville, South Carolina, 29607, United States

  • Valiance Clinical Research

    Tarzana, California, 91356, United States

  • Valiance Clinical Research- Huntington Park

    Huntington Park, California, 91356, United States

  • Valley Institute of Research

    Fort Worth, Texas, 76164, United States

  • Velocity Clinical Research Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research Inc.

    Cincinnati, Ohio, 45219, United States

  • Velocity, San Diego

    La Mesa, California, 91941, United States

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205, United States

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