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Cure My Disease

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New weekly shot could help diabetics shed pounds

NCT ID NCT07400653

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 8 times

Summary

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts about 21 months and will check how much weight participants lose and how their blood sugar changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MET097 (a long-acting GLP-1 receptor agonist)
What this could lead to
If successful, this could provide a new weekly injection option for significant weight loss and better blood sugar control in people with type 2 diabetes.
What could go wrong
This is a Phase 3 trial, but results are not yet known. The drug may cause side effects, and not everyone may achieve meaningful weight loss. Placebo group limits certainty.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,078 people

The number who actually took part.

Started

Feb 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provision of signed and dated informed consent form (ICF) * Male or female adults, aged ≥18 years * Have a BMI at Screening of ≥27.0 kg/m2 * Have T2DM for at least 6 months before Screening based on participant reported history or documentation of the disease diagnostic criteria * Have HbA1c value between ≥6.5% (48 mmol/mol) and ≤10.0% (86.0 mmol/mol) at Screening with stable therapy for at least 90 days prior to Screening/Visit 1. T2DM may be treated with: --Diet and exercise alone or in combination with: Any oral antidiabetic therapy per local labeling EXCEPT DPP-4 inhibitors. Participant may NOT be on GLP-1 agonists or insulin * Participants must be motivated and willing to: * Self-inject study medication (or be aided by caregiver if needed), * Perform finger-stick glucose monitoring as required. * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. Exclusion Criteria: * Female who is breastfeeding, or who is pregnant * Unwilling or unable to follow contraceptive requirements * Diagnosis of Type 1 diabetes, or any other types of diabetes except T2DM. * Severe hypoglycemia and/or hypoglycemia unawareness within the 6 months prior to Screening * Poorly controlled hypertension * Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed \>1 year prior to screening) * Have taken within 3 months prior to randomization, medications (prescribed or over-the counter) intended to promote weight loss * Are receiving or have received within 3 months prior to screening chronic (\>2 weeks or 14 days) systemic glucocorticoid therapy

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Conditions

The condition(s) this trial relates to.

Body Weight diabetes mellitus endocrine system disorder glucose metabolism disease metabolic disease Nutritional and Metabolic Diseases nutritional disorder Obesity obesity disorder overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes type 2 Obesity Overweight Overweight and/or obesity Type 2 diabetes

Contacts and locations

Locations

  • AMR Clinical

    Fort Myers, Florida, 33912, United States

  • Access Eye Institute

    Westlake Village, California, 91361, United States

  • Advanced Clinical Research

    Miami, Florida, 33156, United States

  • Alliance Research Institute

    Canoga Park, California, 91304, United States

  • Amarillo Medical Specialists LLP

    Amarillo, Texas, 79124, United States

  • Ashfields Primary Care Centre

    Sandbach, CW11 1EQ, United Kingdom

  • Bodyline Medical Clinic Warrington Civia Health

    Paddington, WA1 3TZ, United Kingdom

  • Bodyline Medical Clinic, Crosby Civia Health

    Liverpool, L22 4QQ, United Kingdom

  • Bodyline Medical Clinic, St Helens Civia Health

    St Helens, WA9 1AF, United Kingdom

  • Burke Primary Care

    Morganton, North Carolina, 28655, United States

  • CCR Ostrava

    Ostrava, 702 00, Czechia

  • CDG Studienambulanz Hartard

    Munich, Bavaria, 80809, Germany

  • CEDIC

    Buenos Aires, C1060, Argentina

  • CIDIM

    Córdoba, X5000AVE, Argentina

  • CIPADI - Centro Integral de Prevencion Y Atencion en Diabetes

    Godoy Cruz, M5501ARP, Argentina

  • Cardio D&R Košice

    Košice, 040 22, Slovakia

  • Cardiovascular Specialists of Willowbrook

    Houston, Texas, 77070, United States

  • Catalina Research Institute, LLC

    Montclair, California, 91763, United States

  • CenExcel Rocky Mountain Clinical Research, LLC

    Englewood, Colorado, 80113, United States

  • CenExel Anaheim Clinical Trials

    Anaheim, California, 92801, United States

  • CenExel CNS - Collaborative Neuroscience Research

    Los Alamitos, California, 90720, United States

  • CenExel Denver CO (Rocky Mountain Clinical Research)

    Englewood, Colorado, 80113, United States

  • CenExel FCR - ForCare Clinical Research

    Tampa, Florida, 33613, United States

  • CenExel Salt Lake City UT (JBR Clinical Research)

    Salt Lake City, Utah, 84107, United States

  • CenExel iResearch, LLC

    Decatur, Georgia, 30030, United States

  • CenExel iResearch, LLC

    Savannah, Georgia, 31405, United States

  • Centricity Research Etobicoke Endocrinology

    Etobicoke, Ontario, M9R 4E1, Canada

  • Centricity Research Mirabel Multispecialty (Centricity Research)

    Mirabel, Quebec, J7J 2K8, Canada

  • Centro Medico Viamonte

    Buenos Aires, Argentina

  • Centro de Investigaciones Metabólicas (CINME)

    Buenos Aires, C1056ABI, Argentina

  • Centro de Investigaciones Médicas Tucuman

    San Miguel de Tucumán, T4000AXL, Argentina

  • Centru Medical "GRANDMED"

    Oradea, 410032, Romania

  • Centrul Medical Mediab - Mediab Srl

    Târgu Mureş, 540142, Romania

  • Centrum Badan Klinicznych PI-House Sp. z o.o.

    Gdansk, 80-546, Poland

  • Centrum Medyczne Pratia Gdynia

    Gdynia, 81-338, Poland

  • Centrum Medyczne Pratia Katowice

    Katowice, 40-081, Poland

  • Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna

    Lodz, 90-338, Poland

  • Centrum medyczne Pratia Bydgoszcz

    Bydgoszcz, 85-796, Poland

  • Civia Health Goodlettsville

    Goodlettsville, Tennessee, 37072, United States

  • Civia Health Nashville

    La Vergne, Tennessee, 37086, United States

  • Civia Health Sunderland

    Hendon, CITY of Sunderland, SR1 1PB, United Kingdom

  • Civia Health_Boots Birmingham

    Birmingham, B4 7TA, United Kingdom

  • Civia Health_Boots Nottingham

    Nottingham, NG1 3QS,, United Kingdom

  • Clifton Medical Centre

    Rotherham, S651DA, United Kingdom

  • Clinica Privada Velez Sarsfield

    Córdoba, 5000, Argentina

  • Clinical Innovations, Inc dba CITrials

    Riverside, California, 92506, United States

  • Core Healthcare Group

    Cerritos, California, 90703, United States

  • Cure Clinical Research

    Orange, California, 92866, United States

  • DIABEDA s.r.o.

    Bratislava, 831 06, Slovakia

  • Dallas Clinical Research Center (Pillar Clinical Research)

    Richardson, Texas, 75080, United States

  • DelRicht Research

    Atlanta, Georgia, 30329, United States

  • DelRicht Research

    Springfield, Missouri, 65807, United States

  • DexaFit Los Alamitos

    Los Alamitos, California, 90720, United States

  • Diabetes Studienzentrum Wilhelmsburg

    Hamburg, 21109, Germany

  • Diabetespraxis Dr. Braun

    Berlin, 13187, Germany

  • Diabeteszentrum Hamburg-West

    Hamburg, 22607, Germany

  • Diacentrum Brandys n.L.

    Brandys Nad Lebem, 25001, Czechia

  • Diagnostic Consultative Center Aleksandrovska

    Sofia, 1431, Bulgaria

  • ERA Health Research

    Redmond, Washington, 98052, United States

  • ETG Siedlce

    Siedlce, 08-110, Poland

  • Ecg Médica S.L.

    Valencia, 46015, Spain

  • Edumed s.r.o.

    Náchod, 54701, Czechia

  • Ekamed Sp. z o. o.

    Lublin, 20-718, Poland

  • Etg Warszawa

    Warsaw, 02-677, Poland

  • Eximia EquiHealth Research

    Durham, North Carolina, 27704, United States

  • Eximia Research - NC, LLC

    Raleigh, North Carolina, 27607, United States

  • Eye Consultants PC

    Omaha, Nebraska, 68124, United States

  • Fakultní nemocnice Královské Vinohrady

    Prague, 100 34, Czechia

  • Forum Austin (Civia Health)

    Austin, Texas, 78578, United States

  • Forum Health_Cary (Civia)

    Cary, North Carolina, 27511, United States

  • Fundatia Dr Victor Babes

    Bucharest, 30303, Romania

  • Future Medical Research (Civia Health)

    Longwood, Florida, 32750, United States

  • FutureMeds Berlin

    Berlin, 10629, Germany

  • FutureMeds Birmingham

    Birmingham, B21 9RY, United Kingdom

  • FutureMeds Frankfurt/Offenbach

    Offenbach, 63065, Germany

  • FutureMeds Glasgow McCafferty House

    Glasgow, Scotland, G20 7BE, United Kingdom

  • FutureMeds Liverpool

    Bromborough, CH62 6EE, United Kingdom

  • FutureMeds London

    London, NW10 2PB, United Kingdom

  • FutureMeds Newcastle

    Newcastle upon Tyne, NE6 1SG, United Kingdom

  • FutureMeds Olsztyn

    Olsztyn, 10-165, Poland

  • FutureMeds Plovdiv

    Plovdiv, 4000, Bulgaria

  • FutureMeds Teesside

    Stockton-on-Tees, TS19 8PE, United Kingdom

  • Futuremeds S.R.L., Brasov

    Brasov, 500388, Romania

  • Futuremeds S.R.L., Craiova

    Craiova, 200115, Romania

  • Futuremeds S.R.L., Galati

    Galati, 800183, Romania

  • Futuremeds Spain Cadiz

    Chiclana de la Frontera, 11139, Spain

  • Futuremeds Spain Madrid

    Madrid, 28003, Spain

  • Futuremeds Spain Sevilla

    Seville, 41012, Spain

  • GLRI El Paso Research

    El Paso, Texas, 79936, United States

  • Gemeinschaftspraxis Dres. H.Kittner und K.Hartig

    Naunhof, 04683, Germany

  • Hassman Research Institute

    Marlton, New Jersey, 08053, United States

  • Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

    Bucharest, 011053, Romania

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga, 29010, Spain

  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, 11540, Spain

  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, 41950, Spain

  • IRMED

    Piotrkow Trybunalski, 97-300, Poland

  • Indago Research & Health Center, Inc

    Miami Lakes, Florida, 33016, United States

  • Instituto Medico Catamarca (IMEC)

    Santa Fe, S2000, Argentina

  • Instituto de Investigaciones Clinicas Cordoba

    Córdoba, X5000AAW, Argentina

  • Institutul Clinic Fundeni

    Bucharest, 022328, Romania

  • Institutul National de Endocrinologie "C.I. Parhon"

    Bucharest, 011863, Romania

  • Instytut Diabetologii.sp.z.o.o.

    Warsaw, 02-117, Poland

  • JAL s.r.o.

    Trnava, 91701, Slovakia

  • Kiltearn Medical Centre

    Nantwich, CW5 5NX, United Kingdom

  • Klinische Forschung Berlin-Mitte GmbH

    Berlin, 10117, Germany

  • Klinische Forschung Dresden GmbH / Pratia

    Dresden, 01069, Germany

  • Klinische Forschung Hamburg GmbH / Pratia

    Hamburg, 20253, Germany

  • Klinische Forschung Karlsruhe GmbH

    Karlsruhe, 76137, Germany

  • LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

    Toronto, Ontario, M4G 3E8, Canada

  • Lundquist Institute for Biomedical Innovation at Harbor- UCLA Medical Center

    Torrance, California, 90502, United States

  • MC Nevromedics Ltd.

    Veliko Tarnovo, 5005, Bulgaria

  • MHAT Botevgrad

    Botevgrad, 2140, Bulgaria

  • MHAT Sveta Karidad EAD

    Plovdiv, 4004, Bulgaria

  • Medical Center - Clinic Nova EOOD

    Varna, 9000, Bulgaria

  • Medical Center 4 Life EOOD, Burgas

    Burgas, 8018, Bulgaria

  • Medical Center Berbatov

    Yambol, 8600, Bulgaria

  • Medical Center Hera EOOD

    Sofia, 1710, Bulgaria

  • Medical Center New Polyclinic Gabrovo Ltd.

    Gabrovo, 5300, Bulgaria

  • Medical Center Zdrave 1

    Kozloduy, 3320, Bulgaria

  • Medical Centre Pratia Clinic EOOD

    Varna, 9020, Bulgaria

  • Medical group Kosice s.r.o.

    Košice, 04001, Slovakia

  • Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych

    Oświęcim, 32-600, Poland

  • Medislim GmbH

    Weinheim, 69469, Germany

  • Medispektrum s.r.o.

    Bratislava, 85101, Slovakia

  • Medivasa s.r.o

    Žilina, 010 01, Slovakia

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

    Tarnów, 33-100, Poland

  • Miami Eye Institute

    Hollywood, Florida, 33024, United States

  • Minimed S.R.L.

    Bacau, 600274, Romania

  • Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

    Dobrich, 9300, Bulgaria

  • Murray Vision Center PC

    Salt Lake City, Utah, 84107, United States

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231, Poland

  • Neuro-Sight Vision Care

    Lakewood, Colorado, 80226, United States

  • Nuevas Tecnologías en Diabetes y Endocrinología S.L.

    Seville, 41003, Spain

  • Optimal Research Sites, LLC

    Orange City, Florida, 32763, United States

  • Oviedo Medical Research

    Oviedo, Florida, 32765, United States

  • Pantheon Clinical Research

    Bountiful, Utah, 84010, United States

  • Panthera Biopartners Limited - Enfield

    Enfield, EN3 4GS, United Kingdom

  • Panthera Biopartners Limited - Glasgow

    Glasgow, G51 4RY, United Kingdom

  • Panthera Biopartners Limited - Preston

    Preston, PR2 9QB, United Kingdom

  • Panthera Biopartners Limited - Rochdale

    Rochdale, OL11 4AU, United Kingdom

  • Panthera Biopartners Limited - Sheffield

    Sheffield, S2 5FX, United Kingdom

  • Panthera Biopartners Limited - York

    York, YO24 4LJ, United Kingdom

  • Patient First Clinical Trials (PFCTRIALS)

    Lutherville, Maryland, 21093, United States

  • Pedro P. Ylisastigui, MD

    Fort Myers, Florida, 33912, United States

  • Poliklinika Váš Lekár

    Bratislava - Ružinov, 91109, Slovakia

  • Practice Dr. Kirsch and Colleague, Zentrum fur klinische Forschung

    Cologne, 51069, Germany

  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655, Poland

  • Pratia Chojnice

    Chojnice, 89-600, Poland

  • Pratia Pardubice

    Pardubice, 53002, Czechia

  • Praxis Reinfeld Mitte

    Holstein, 23858, Germany

  • Praxis am Markt - Dr. Bernd Becker

    Essen, 45355, Germany

  • Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

    Stara Zagora, 6000, Bulgaria

  • Primary clinical Research

    Papillion, Nebraska, 68046, United States

  • Private Practice Adjacent to For Eyes Optical

    Hialeah, Florida, 33014, United States

  • Quality Clinical Research Inc

    Omaha, Nebraska, 68114, United States

  • ResTrial s.r.o.

    Prague, 18100, Czechia

  • Research Centers of America

    Hollywood, Florida, 33024, United States

  • Retina Consultants of Orange County

    Fullerton, California, 92835, United States

  • Retina Consultants of Orange County

    Los Alamitos, California, 90720, United States

  • Rolling Oaks Radiology -Palms

    Oxnard, California, 93036, United States

  • Sahana Optometry PLLC dba Family Eye Wellness

    Holly Springs, North Carolina, 27540, United States

  • Santa Familia PTG Lodz

    Lodz, WOJ Lodzkie, 90-302, Poland

  • Sc Gensan Srl/Policlinica Astra

    Sibiu, 550371, Romania

  • Southmead Hospital

    Bristol, BS10 5NB, United Kingdom

  • Studienzentrum FMZ Radowsky

    Leipzig, Saxony, 04179, Germany

  • Synexus Glasgow Clinical Research Centre

    Bellshill, ML4 3NJ, United Kingdom

  • Synexus Manchester Clinical Research Centre

    Manchester, M15 6SE, United Kingdom

  • Synexus Midlands Clinical Research Centre

    Edgbaston, B16 8QQ, United Kingdom

  • Synexus Polska Sp z o.o.

    Gdansk, 80-382, Poland

  • Synexus Polska Sp. Z O.O. Oddzial W Katowicach

    Katowice, 40-040, Poland

  • Synexus Polska Sp. z o.o. Oddzial w Gdyni

    Gdynia, 81-537, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Czestochowie

    Częstochowa, 42-202, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Lodzi

    Lodz, 90-127, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Warszawie

    Warsaw, 02-672, Poland

  • Synexus Polska Sp. z o.o., Oddział w Poznaniu

    Poznan, 60-702, Poland

  • Synexus Polska Sp. z o.o., Oddział we Wrocławiu

    Wroclaw, 50-381, Poland

  • Synexus/Trialmed Prague

    Prague, 120 00, Czechia

  • Tatratrial s.r.o.

    Rožňava, 048 01, Slovakia

  • The Wharton Medical Clinic Clinical Trials Inc

    Hamilton, Ontario, L8L 5G8, Canada

  • Trialmed CRS

    Piotrkow Trybunalski, 97-300, Poland

  • Tribe Clinical Research LLC. - Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Tribe Clinical Research LLC.- Greenville

    Greenville, South Carolina, 29607, United States

  • Upgrade Performance Institute

    Elkhorn, Nebraska, 68022, United States

  • Velocity Clinical Research Germany

    Berlin, 10787, Germany

  • Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

    Bialystok, 15-351, Poland

  • Zentrum für klinische Forschung Allgäu-Oberschwaben

    Wangen, 88239, Germany

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