Arthropathy

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

Researchers are testing whether apremilast helps people with early psoriatic arthritis that affects only a few joints. Participants have had symptoms for five years or less and still have joint pain and swelling despite stable treatment with NSAIDs or one conventional DMARD. The …

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This trial tests two treatments for a jaw joint condition called TMJ disc displacement with reduction, where the disc that cushions the joint slips out of place but returns to normal when the mouth opens. Researchers will compare injecting hyaluronic acid, a natural lubricant, ag…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This trial tests whether blood-flow-restriction (BFR) training, done before knee replacement surgery, can reduce pain and boost strength. BFR uses a cuff to partially block blood flow during low-weight exercise, which may build muscle without heavy loads. About 19 people schedule…

This study tracks 245 adults aged 18 to 60 who receive a Vivacit-E liner during hip replacement surgery. The liner is a plastic cup that fits inside the hip socket to allow smooth movement. Researchers measure how long the liner stays in place without needing removal, and they ch…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-stage trial evaluates an experimental drug called ZB002, given as an injection under the skin. In the first part, healthy volunteers receive a single dose to check safety and how the drug moves through the body. In the second part, people with rheumatoid arthritis rece…

This trial tests whether a single injection of ICM-203, a gene therapy, can safely help people with mild-to-moderate knee osteoarthritis. The therapy delivers a gene into the knee joint that may encourage cartilage growth, reduce inflammation and pain, and improve daily movement.…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This trial tests whether screening for anemia at the time a patient consents to hip or knee replacement surgery, which is usually 4 to 6 months before the operation, leads to better outcomes than the standard approach of testing only 2 to 4 weeks before surgery. About 800 adults …

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This trial tests whether older adults with knee osteoarthritis can improve balance and mobility through a smartphone-based rehabilitation program at home, compared with the same exercises done in person at a clinic. Both groups follow a six-week program with four sessions per wee…

This trial tests whether injecting platelet-rich fibrin (a substance made from the patient's own blood) into the jaw joint, along with botulinum toxin (Botox) into a nearby muscle, improves symptoms of anterior disc displacement, a common TMJ disorder. The study includes 39 peopl…

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This trial tests whether digital tools can help people with mild to moderate hip or knee osteoarthritis manage their condition without surgery. Participants receive one of three options: usual care with a handout, a physical activity prescription from a doctor using a smartphone …

This trial tests a device called the NUsurface Meniscus Implant for people with a damaged or removed meniscus in the knee. The implant is designed to act like a natural meniscus, cushioning the knee and reducing pain. Researchers will measure changes in knee pain and function usi…

This trial tests whether a 4-week prehabilitation program before total knee replacement can improve recovery. The program includes physical therapy, breathing exercises, psychological support, and targeted treatments based on each person's osteoarthritis type. Researchers will co…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This trial is testing whether combining certolizumab pegol, an injectable biologic, with methotrexate, a standard oral medication, can help adults with early active rheumatoid arthritis achieve and maintain remission. Participants are newly diagnosed, have not yet taken disease-m…

This trial tests whether combining certolizumab pegol (Cimzia) with methotrexate can help adults with early, active rheumatoid arthritis achieve and maintain low disease activity without flare-ups. Participants who already responded well to this combination in a prior study conti…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This phase 3 study tests guselkumab (Tremfya) in 453 adults with active psoriatic arthritis who did not respond to or could not tolerate a prior anti-TNF drug. Participants receive either guselkumab or a placebo injection. The main goal is to see if guselkumab reduces joint swell…

This study tests whether an AI-guided exercise program done at home can be as good as traditional in-person physiotherapy for patellofemoral pain syndrome, a common cause of front knee pain in active adults. Adults aged 18-40 with this condition will be randomly assigned to eithe…

This study compares two supervised exercise programs—motor control retraining and close kinetic chain exercises—to see which better reduces pain, improves knee function, and strengthens a key thigh muscle in people with patellofemoral pain syndrome (pain around the kneecap). Fift…

This study tests whether the oral drug upadacitinib works better than the injected drug adalimumab for adults with moderate to severe rheumatoid arthritis who still have symptoms after trying one TNF blocker. About 480 participants will be randomly assigned to receive either upad…

This trial compares two types of surgical tools used during total hip replacement: single-use (disposable) reaming instruments and conventional reusable ones. The main focus is on the overall cost of surgery, including sterilization, materials, and operating room time. Researcher…

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures …

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injecti…

This study is testing two injectable drugs, ustekinumab and guselkumab, in 50 children with active juvenile psoriatic arthritis. The goal is to see how well the drugs work, how they move through the body, and if they are safe. Participants will receive one of the drugs and be mon…

This trial tests whether a plastic meniscus implant can outperform non-surgical treatments for people with persistent knee pain after a partial meniscus removal. Participants who had the surgery more than six months ago and are between 30 and 75 years old are randomly assigned to…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small sc…

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This study tested whether combining two drugs (guselkumab and golimumab) works better than one drug alone for people with active psoriatic arthritis who didn't get enough relief from previous TNF-alpha blockers. 91 adults took part. The goal was to see if the combo could help mor…

This trial investigates whether people with knee osteoarthritis who also have a bowleg deformity (tibia vara) experience different pain relief after a partial knee replacement compared to those without the deformity. The study will measure medial knee pain using a standard pain s…

This Phase 3 trial tested bimekizumab, a drug given by injection, against a placebo in 400 adults with active psoriatic arthritis who had not responded well to TNF-alpha inhibitors. The study aimed to see if bimekizumab could reduce joint pain and swelling and improve daily funct…

This study tested a drug called bimekizumab in 852 adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin patches. Participants received either bimekizumab, a placebo, or an existing treatment (adalimumab). The main goal was to see if bimekizum…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This trial compares standard knee replacement surgery to surgery using custom cutting blocks designed from each patient's anatomy. The goal is to see if these personalized tools lead to better knee function, less bleeding, shorter surgery time, and lower overall costs. About 95 p…

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This study tests whether a three-month resistance training program using ankle weights can improve leg strength, balance, pain, and quality of life in people who have had knee replacement surgery for osteoarthritis. Twenty-four participants are randomly assigned to either the res…

This trial tests whether a collagen-based injection (Fibroquel) works as well as a standard hyaluronic acid injection (Synvisc) for knee osteoarthritis. About 32 adults with moderate knee OA will receive three weekly injections of one treatment. The study measures knee function a…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measure…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This study tested whether adding a daily fiber supplement (inulin) to standard anti-IL-17 therapy could improve gut bacteria balance and treatment response in 76 adults with axial spondyloarthritis. Participants took either fiber or a placebo powder for three months. The main goa…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use re…

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This early-stage trial tested a new injection for wrist osteoarthritis that combines the patient's own fat (microfat) and platelet-rich plasma (PRP). The goal was to see if this mixture is safe and can reduce pain and improve wrist function, potentially delaying the need for surg…

This study tested whether a personalized surgical guide (TOKA) helps surgeons correct knee alignment more accurately than standard tools. 56 adults with medial knee osteoarthritis took part. The goal was to see if the custom approach leads to better bone alignment after surgery, …

This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. Th…

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This study tested whether platelet-rich plasma (PRP) injections can help people with a jaw condition where the joint slips out of place (TMJ subluxation). Forty adults received two injections of PRP, made from their own blood, with either a low or high platelet concentration. Res…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This study tested whether ultrasound could detect signs of rheumatoid arthritis (RA) relapse before symptoms appear in patients treated with rituximab. Thirty adults with RA who had not responded to at least one TNF-blocking drug were included. Researchers used ultrasound to meas…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested whether taking a probiotic called VSL#3, alongside standard treatment, can reduce disease activity in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took either the probiotic or a placebo. Researchers…

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This Phase 3 trial tested a new one-step treatment called IMPACT for knee cartilage damage. It combines the patient's own cartilage cells with donor stem cells, applied during a single surgery. 60 people aged 18-45 with moderate to severe cartilage lesions were randomly assigned …

This study looked at how well upadacitinib, an anti-inflammatory pill, controls pain in people with axial spondylarthritis (axSpA), a condition causing chronic back pain. Over 700 adults from 19 countries took the drug as prescribed by their doctors and were followed for 12 month…

This study followed 302 children with juvenile idiopathic arthritis (JIA) who had previously taken tofacitinib in earlier studies. The goal was to see how safe the drug is over the long term, by tracking side effects, lab results, and growth. Children took tofacitinib twice daily…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study looked at the safety and performance of the Journey II UNI partial knee replacement in 154 people with knee arthritis. The main goal was to see how many implants were still working well 5 years after surgery. Researchers also tracked any side effects and checked X-rays…

This study tested a daily pill called upadacitinib in 734 adults with axial spondyloarthritis, a type of arthritis that causes pain and stiffness in the spine. The drug was compared to a placebo to see if it could reduce symptoms and control the disease. Results showed that upada…

This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrex…

This study looked at 70 people with psoriatic arthritis to compare two drug types: upadacitinib and IL-17 inhibitors. Researchers tracked joint and skin symptoms over 24 weeks in routine care. The goal is to see which works better in real life, helping doctors personalize treatme…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study followed 218 people who received a cementless POLARSTEM hip implant to treat osteoarthritis. Researchers tracked how well the implant worked and how long it lasted over up to 10 years. The goal was to see if this implant is a safe and effective option for hip replaceme…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This early study tested a new drug called EF-M2 (Immutalon) in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to shift immune cells from a pro-inflammatory to an anti-inflammatory state. Participants received injections for 4 weeks, and researchers m…

This Phase 2 trial tested Proximod, a daily pill that calms the immune system, in 179 adults with moderate-to-severe rheumatoid arthritis who had not responded well to standard treatments. Participants took either 5 mg, 10 mg, or a placebo daily for three months, with one month o…

This phase 3 study tested the drug bimekizumab against a placebo in 274 adults with active nonradiographic axial spondyloarthritis, a form of arthritis that causes back pain but doesn't appear on X-rays. Participants received injections of either the drug or a placebo over severa…

This study tested a drug called bimekizumab in 332 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. Participants received either the drug or a placebo injection. The goal was to see if the drug could reduce symptoms like pain and…

This study tested a new shoulder implant called PyroTITAN HRA in 156 people with arthritis. The implant resurfaces the ball part of the shoulder joint to relieve pain and improve function. Researchers tracked how long the device lasted and whether it caused problems, aiming to se…

This study compared 6 weeks versus 12 weeks of antibiotics for people with infected hip or knee prostheses who had surgery. Researchers wanted to see if the shorter course was just as effective at curing the infection without increasing relapse. The trial enrolled 410 adults acro…

This study tested whether using computer-guided surgery is better than the standard approach for fixing a jaw that keeps dislocating. Seven adults with the condition took part. The main goal was to see if the jaw stayed in place after surgery, and the study also measured how wide…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study compared two ways to perform partial knee replacement for osteoarthritis: using a robotic system (Navio) versus traditional manual tools. 66 adults with knee osteoarthritis took part. The goal was to see if robotic assistance leads to better leg alignment and implant p…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This study tested whether adding GOLimumab to methotrexate works better than methotrexate alone for people with very early psoriatic arthritis (PsA). 84 adults with active PsA diagnosed within the last 2 years took part. The main goal was to see if the combination improved diseas…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study tested two methods to help people with rheumatoid arthritis stop taking steroids (prednisone) safely. 102 adults with low disease activity or remission were given either a gradual dose reduction or a replacement with hydrocortisone. The goal was to see which approach a…

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for sev…

This study tested three different doses of tranexamic acid, a drug that helps blood clot, to see which works best for reducing blood loss during hip replacement surgery. 170 patients were randomly assigned to receive either a placebo or one of three doses of the drug right at the…

This completed trial tested whether starting stronger medications early helps people with moderate to severe psoriatic arthritis more than the usual step-up approach. 192 adults were randomly assigned to standard care, early combination disease-modifying drugs, or early TNF inhib…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with systemic sclerosis (scleroderma). Twenty-two adults with active arthritis took rituximab or a placebo, plus standard care. Researchers c…

This study tested an intravenous drug called golimumab in 130 children with active juvenile idiopathic arthritis that did not improve with methotrexate. The main goal was to measure how the drug moves through the body over time. The study was completed and provides information on…

This study tested a program to help people with rheumatoid arthritis (RA) get their cholesterol checked and treated. Many RA patients are at higher risk for heart attacks and strokes but often miss out on proper screening. The program used peer coaches and educational materials t…

This study tested two biologic drugs, secukinumab and ustekinumab, in 119 adults with active psoriatic arthritis who had not responded to or could not tolerate TNFα-inhibitor treatment. The main goal was to see which drug better improved physical function over 28 weeks. Researche…

This study looked at the long-term safety and effectiveness of the drug secukinumab in children with two types of juvenile idiopathic arthritis: juvenile psoriatic arthritis and enthesitis related arthritis. Fifty-five children who had already completed a previous study continued…

This study tested whether adding nipocalimab to the standard drug certolizumab works better than certolizumab alone for people with active rheumatoid arthritis. It involved 103 adults who still had moderate to severe symptoms despite trying other advanced treatments. The main goa…

This early-phase trial tested a single infusion of stem cells taken from the patient's own belly fat in 15 adults with active rheumatoid arthritis. The main goal was to see if the treatment is safe over 12 months. Researchers also looked at whether it could lower inflammation mar…

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This early-stage study tested a new oral drug called SAR441566 in 10 healthy Japanese men to see how safe it is and how the body processes it. The drug is being developed for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. The study only looked at…

This study looked at whether giving tranexamic acid (a drug that helps blood clot) during knee replacement surgery reduces blood loss, and if a surgical drain is still needed. 192 patients with knee osteoarthritis were split into three groups: one got the drug plus a drain, one g…

This study looked at the long-term safety of the drug tocilizumab (Actemra) in 7 children with a type of arthritis called juvenile idiopathic arthritis. All children had already completed a previous study and continued to receive the drug every 4 weeks for up to 2 years. The main…

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This completed study looked at whether a nurse-led program of self-assessment and self-management, plus standardized screening for other health problems, helps people with axial spondyloarthritis. Over 500 adults took part. The goal was to see if this approach improves how patien…

This study followed 526 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctors. Researchers observed them for up to 100 weeks to see how well the drug controlled their symptoms in everyday practice. The goal was to gather long-term…

This completed study followed 413 Canadian adults with moderate to severe rheumatoid arthritis who were prescribed upadacitinib by their doctors. Researchers tracked how well the drug controlled symptoms like joint pain and stiffness over 24 months. The goal was to see if the dru…

Researchers are testing whether ultrasound can reliably show joint damage and inflammation in people with septic arthritis, a painful joint infection. The trial follows 28 adults with septic arthritis in the shoulder, elbow, wrist, hip, knee, or ankle. Participants receive standa…

This study tests whether artificial intelligence (AI) can help emergency room doctors find broken bones, dislocations, and other bone problems more quickly and accurately. About 4,800 patients with arm or leg injuries will have their X-rays reviewed either with or without AI assi…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study investigates whether three common lab tests — blood levels of ESR and CRP, plus a leukocyte esterase dipstick test on joint fluid — can reliably diagnose chronic infection in people who have had a total joint replacement. The researchers will compare the test results a…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

About 25% of people who have knee replacement surgery develop persistent pain that can last for months. This trial tests whether taking a CBD-dominant oil before and after surgery can reduce that risk. Researchers will randomly assign about 40 adults to receive either CBD oil or …

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain an…

Researchers compare spinal anesthesia and general anesthesia for people having hip or knee replacement surgery for osteoarthritis. The trial checks whether patients can safely walk 5 meters within 6 hours after surgery and how they feel in terms of pain, nausea, dizziness, confus…

Researchers are testing whether an online exercise and self-massage program can lower jaw pain and improve jaw movement in adults with bruxism, the habit of grinding or clenching teeth. Participants complete eight sessions over four weeks, either exercising live with a physical t…

Researchers are testing whether a 12-week Taekwondo training program can help adults with ankylosing spondylitis and axial spondyloarthritis. The trial enrolls 21 adults aged 19 to 59 who have stable treatment or no medication for at least three months. Participants join either a…

Researchers are comparing two single injections for knee osteoarthritis: an experimental polyacrylamide hydrogel gel and a standard hyaluronic acid shot called Synvisc-One. The trial enrolls about 238 adults aged 40 and older with mild to moderate knee arthritis confirmed by X-ra…

This study compares two types of nerve blocks—SFIB and PENG—to see which one controls pain better after hip replacement surgery. Sixty patients will be randomly assigned to receive one of the blocks. The main goal is to measure how much morphine they need in the first 24 hours af…

This study looks at whether walking football—a low-impact, no-running version of soccer—is safe and helpful for people with axial spondyloarthritis, a long-term inflammatory spine condition. Twelve participants will play twice a week for 12 weeks. Researchers will measure pain, s…

This study looks at whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the knee can reduce pain and improve movement in people with knee osteoarthritis. The trial involves 110 adults over 35 with knee arthritis. Researchers are…

Researchers at the University of Porto studied 30 adults with myofascial temporomandibular disorder who still had jaw muscle pain after using a stabilization splint for at least five years. All participants kept using their splints and received four weekly 30-minute acupuncture s…

Researchers are testing whether combining extracorporeal shockwave therapy with injections of hyaluronic acid or platelet-rich plasma eases pain and improves knee function better than shockwave therapy alone in people with moderate to severe knee osteoarthritis. The trial enrolls…

Researchers compare the GDS Muscle and Joint Chains Method with conventional physiotherapy in adults with frozen shoulder. Thirty participants receive eight 50-minute sessions over four weeks. The trial measures changes in shoulder range of motion and pain intensity to see whethe…

Researchers compare two treatments for long head of the biceps brachii tendinopathy, a common cause of shoulder pain. One group receives a single ultrasound-guided injection of triamcinolone acetonide and lidocaine around the tendon. The other group receives transcutaneous electr…

This study tested a special carbon fiber plate and screws to treat hallux rigidus, a condition that causes stiffness and pain in the big toe joint. 18 adults who needed surgery for this condition took part. The surgery removed damaged cartilage and fused the bones together using …

This pilot study tests whether a minimally invasive technique called percutaneous needle electrolysis can reduce groin pain and improve hip function in male ice hockey players aged 18 to 21. Six players will receive three ultrasound-guided treatments to the hip capsule. Researche…

This study tests whether a manual therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in people with knee osteoarthritis. Forty adults with moderate to severe knee OA will receive either MWM or a sham treatment twice a week for four weeks, plus standa…

This study tests whether physical therapy, combined with motivational support and planning, can help older adults with chronic hip, knee, or back pain become more physically active. Participants work with physical therapists to set personal goals and adapt activities to their con…

This trial tests whether S(+) ibuprofen, a purified form of the common painkiller, can reduce pain in people with knee or hip osteoarthritis better than a standard ibuprofen product. Researchers will compare the two treatments in about 176 adults aged 18 to 75. Participants will …

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tests a new treatment called BRC-OA, made from donated human fat tissue, for people with mild to severe knee osteoarthritis. The goal is to see if it safely reduces pain and improves knee function. About 42 adults aged 18-80 will receive one of two doses or a control, …

This study compares two ultrasound-guided procedures that target nerves around the knee to relieve chronic osteoarthritis pain that has not improved with standard care. One procedure uses heat from radiofrequency to disable the nerves, while the other uses a chemical called pheno…

This study tests whether a guided exercise program done at home before knee replacement surgery can help people recover better. 84 adults scheduled for knee replacement will be asked to do simple exercises daily from the day they are admitted until surgery. Researchers will measu…

This trial tests whether brief mindfulness-based audio recordings can ease pain and improve jaw function in university students with painful temporomandibular disorders (TMD), a common cause of chronic jaw pain. Participants listen to the recordings three times a week for three m…

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This trial tests whether a single injection of lorecivivint into the knee can reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 499 adults aged 40 to 80 will receive either the drug or a placebo injection, and researchers will compare c…

This trial tests whether coaching older adults in healthy habits or sleep habits can improve their recovery after hip or knee replacement surgery. Participants receive four hour-long sessions with a therapist, focusing either on general healthy habits like physical activity and n…

This study looked at whether adding heat therapy or contrast therapy (alternating hot and cold) to a specific exercise program helps people with patellofemoral pain syndrome, a common cause of front knee pain. Forty adults aged 18 to 40 with at least three months of knee pain too…

This study tests whether a special laser (LightForce) can reduce shoulder pain caused by inflammation from conditions like impingement or rotator cuff tendinitis. About 130 adults with pain lasting over 3 months will get either real laser or a sham laser, plus standard physiother…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This study tests whether adding a suprascapular nerve block (a temporary numbing injection) to standard frozen shoulder treatments helps people recover faster. About 62 adults with limited shoulder movement will be randomly assigned to get either the nerve block plus usual care o…

This study tests if a biceps tendon cutting procedure (tenotomy) done in the doctor's office with a tiny camera and local anesthesia works as well as the same surgery in an operating room. 14 adults with shoulder pain from biceps or rotator cuff problems will be enrolled. The mai…

This study tests whether blood flow restriction training (BFRT) — using pressure cuffs during low-load exercise — can help people with rheumatoid or psoriatic arthritis build muscle with less joint strain than conventional strength training. Adults with these conditions will be r…

This study looked at how satisfied people were with three different types of mouthguards (occlusal splints) for jaw joint and muscle pain (TMD). 27 adults who had jaw pain for at least 3 months and had never been treated for it tried one of the splints. The main goal was to see w…

This trial tests whether online educational modules or live webinars, completed before hip replacement surgery, can reduce anxiety and improve outcomes like pain, function, and quality of life. It involves adults aged 50 and older with advanced hip osteoarthritis who are schedule…

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exerc…

This trial tests whether giving patients an educational booklet before total knee replacement surgery improves their knowledge and beliefs about the procedure. Adults aged 55 to 75 scheduled for knee replacement will receive the booklet or standard care. Researchers will measure …

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with…

This study tests whether an 8-week Pilates program can reduce pain and improve jaw function in women with myogenic temporomandibular disorders (TMD), a common cause of jaw pain and stiffness. Participants will be randomly assigned to either a control group receiving standard educ…

This trial asks whether a numbing injection directly into the knee works as well as a continuous nerve block for controlling pain after knee replacement surgery. Adults aged 18 to 90 with knee arthritis scheduled for a first knee replacement are randomly assigned to receive eithe…

This study tests whether a cream made with cetylated fatty acids can ease knee pain and improve function in adults with osteoarthritis. Participants apply the cream or a placebo to the affected knee twice daily for 30 days. The trial measures changes in pain during walking, physi…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This trial tests whether adding a self-management education program to a three-week spa treatment can increase physical activity levels in people with knee osteoarthritis. The program includes educational workshops and a written booklet, and the study will measure physical activi…

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study compares two injection treatments for frozen shoulder (adhesive capsulitis). One group receives a standard steroid injection, while the other gets the same steroid plus extra saline to gently stretch the shoulder capsule. Researchers will measure pain, range of motion,…

This study compares acute pain after partial knee replacement (unicompartmental knee arthroplasty) between patients who go home the same day and those who stay in the hospital. Researchers track pain scores and knee function in 244 adults aged 50 to 75. The goal is to see whether…

This study tested whether steroid injections given every two weeks can improve shoulder function and reduce pain in people with frozen shoulder. Forty adults received either an ultrasound-guided injection into the shoulder or a shot in the buttock, plus a placebo. The goal was to…

This study tests whether an ultrasound-guided injection of local anesthetic into the space behind the knee (called the IPACK block) can reduce pain and improve function in people with advanced knee osteoarthritis. Researchers will measure pain, disability, and quality of life at …

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study looks at whether adding core muscle exercises to a hip and knee workout can lower pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). Thirty-six women aged 19-35 with a healthy weight will be assigned to different …

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study compared two types of exercises—clam shell exercises (for hip muscles) and short arc quadriceps exercises (for thigh muscles)—in 34 adults aged 18-40 with patellofemoral pain syndrome, also known as runner's knee. Participants were randomly assigned to one exercise gro…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested a minimally invasive surgery for people with kneecap pain, dislocation, or instability. Surgeons used their finger to guide a small cut to release tight ligaments, aiming for less tissue damage than open surgery. 23 participants were enrolled. The approach may r…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study looked at 20 people with severe hip arthritis who needed a hip replacement. They were randomly assigned to get either a short or a long stem implant. Researchers used 3D motion capture to measure walking patterns before surgery and at several points after, to see if on…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This study tested whether adding a self-massage technique (Self-Mulligan) to online physical therapy helps people with shoulder pain more than online therapy alone. 52 adults with shoulder pain for at least 3 months took part. Both groups improved, but those who also did the self…

This study compared two minimally invasive procedures for knee osteoarthritis pain: genicular nerve radiofrequency ablation and intra-articular pulsed radiofrequency. Both use radiofrequency energy to reduce pain, but in different ways. Researchers enrolled 34 adults with knee os…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…

This study tested two hands-on treatments for frozen shoulder (adhesive capsulitis) in 66 adults aged 40-65. One group received quick thrusts (HVLA), the other a gentler muscle energy technique (MET), both alongside standard physical therapy for four weeks. Both approaches reduce…

This study tested whether retraining deep neck muscles using a pressure biofeedback device could reduce pain and improve movement in people with chronic neck pain and jaw issues. 70 adults with neck pain lasting 3 to 18 months and mild-to-moderate jaw dysfunction took part. One g…

This study tested two manual therapy techniques—Strain Counterstrain and Graston Technique—in 60 adults with patellofemoral pain syndrome (pain around the kneecap). The goal was to see which method better reduces pain and improves knee movement right after treatment. Participants…

This study looked at whether adding ultrasound-guided hyaluronic acid injections to a standard rehab program helps people with frozen shoulder. Sixty adults aged 40 to 70 with frozen-phase adhesive capsulitis took part. One group got three weekly injections plus six weeks of reha…

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested whether using a computer navigation system with special pre-surgery X-rays (EOS imaging) helps surgeons place a new hip joint more accurately. 78 adults with hip osteoarthritis who needed a total hip replacement took part. The goal was to see if this technology …

This study tested whether adding video-call support to standard physical therapy helps people recover better after total knee replacement. 44 adults aged 50-75 with knee arthritis took part. The goal was to see if tele-rehab reduces pain, improves movement, and helps people get b…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study compared two surgeries for severe thumb arthritis: simple removal of a small wrist bone (trapeziectomy) versus removal plus ligament reconstruction (the Weilby procedure). Sixty patients were randomly assigned to one surgery. The goal was to see which provides better p…

This study tested whether a home exercise program guided by the TRAK app could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty patients over age 45 with knee pain took part. The goal was to see if telerehab…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…

This study tested a procedure called arthrocentesis, where the jaw joint is washed out with a salt solution, in 27 adults with long-term jaw pain. Researchers measured joint swelling and pain before the procedure and again at 3 and 6 months after. The goal was to see if the washo…

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether a food formula containing medium-chain triglycerides (MCTs) and vegetable fibers could improve quality of life in 72 adults with psoriatic arthritis and low disease activity. Participants took the formula for 3 months while continuing their usual medicat…

This study tested two drugs, colchicine and prednisone, to see which works better for sudden, severe joint pain caused by CPPD arthritis (a type of arthritis common in older adults). The trial involved 111 hospitalized patients aged 65 and older. Researchers measured pain relief …

This study tested a mobile app designed to help people with rheumatoid arthritis manage their condition. 90 adults with stable treatment used the app for 12 weeks, while a control group received usual care. Researchers measured changes in disease activity and quality of life to s…

This study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…

This study tested whether giving the sedative drug dexmedetomidine during knee replacement surgery could lengthen the time before patients need additional painkillers. 94 adults having elective knee replacement under regional anesthesia received either the drug or a placebo. The …

This study tested whether adding a nerve block (adductor canal block) to standard local pain injections reduces pain after knee replacement surgery better than injections alone. 61 adults having knee replacement took part. The goal was to find a way to improve pain control and he…

This study looked at 130 people having knee replacement surgery for osteoarthritis. It compared two ways to manage pain: one using a nerve block near the knee, and the other adding extra numbing medicine around the joint. The goal was to see which method helped patients recover f…

This study tested whether a health coaching program (called CAPPA) combined with a Fitbit could help employees with chronic knee pain become more physically active. Thirty-nine participants were split into two groups: one received physical activity coaching, the other received ge…

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study tested whether eccentric muscle training (lengthening exercises) improves walking performance in people with knee osteoarthritis compared to standard concentric training (shortening exercises). Forty adults aged 40-85 with knee osteoarthritis participated in 6 weeks of…

This study tested whether adding a genicular nerve block to a standard femoral nerve block improves pain control after total knee replacement. Eighty adults having knee surgery were split into two groups: one got the standard block, the other got both blocks. Researchers measured…

This study tested two physical therapy methods for people with moderate knee osteoarthritis (grade II). One group received hands-on manual therapy (joint mobilization, massage), while the other got standard exercises and electrotherapy. Over 6-8 weeks, researchers measured pain, …

This study tested if dry needling (inserting thin needles into muscle knots) can reduce jaw pain in people with temporomandibular disorder (TMD). 40 adults with jaw pain for at least 3 months were randomly assigned to receive either dry needling or standard physical therapy. The …

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested a special insole that measures foot pressure to help people walk better after hip replacement surgery. 200 adults were split into four groups: some used the smart insole with real-time feedback, some without feedback, some used a different device, and some had s…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested whether AI chatbots (ChatGPT and DeepSeek) could help create better exercise plans for people with shoulder pain (subacromial pain syndrome). 75 adults were split into three groups: standard physiotherapy, standard plus ChatGPT exercises, or standard plus DeepSe…

This study looked at whether adding a nerve block (PENG block) to a standard steroid injection into the hip joint can better relieve pain from hip osteoarthritis. Researchers followed 50 patients whose pain persisted despite other treatments. The goal was to see if the combinatio…

This study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…

This study tested whether an injection made from human placenta, called LAENNEC, can reduce shoulder pain in people with shoulder impingement syndrome. 50 adults with shoulder pain received either the LAENNEC injection or a placebo, guided by ultrasound. The main goal was to see …

This study tested whether a custom knee brace connected to a mobile app and motion sensors can improve symptoms and daily function for people with knee osteoarthritis. 36 adults aged 45-75 with mild to moderate knee OA wore their assigned brace for 6 months and completed surveys …

This early-stage study tested a new drug called APPA-1 in 40 healthy volunteers and people with osteoarthritis. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at how food and gender affect the drug. This is a first step to see …

This study tested a new treatment for knee osteoarthritis using stem cells from umbilical cord tissue. 31 people aged 55-70 with moderate knee arthritis received the stem cells either with or without a minor knee surgery (arthroscopy). The goal was to see if the treatment could r…

This small pilot study tested an 8-week exercise program for 20 adults with axial spondyloarthritis, a type of arthritis that affects the spine and can restrict breathing. The program included aerobic exercise, strength training, and breathing exercises. Researchers measured chan…

This study tested whether two structured telemedicine visits, added between regular doctor appointments, could help people with psoriatic arthritis improve their quality of life and reduce disease impact. 101 adults with active symptoms took part. The visits focused on lifestyle …

This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate-to-severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants reported their pain levels weekly, an…

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study tested a single injection of a drug called lorecivivint in the knee joint of 496 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo (fake injection) over 28 weeks. Participants reported…

This study looked at whether telehealth follow-up (phone or video calls) after total knee replacement helps patients regain function, take care of themselves, and do daily activities better than standard discharge instructions. About 60 adults who had knee replacement surgery wer…

This study tested whether injecting a patient's own processed fat tissue into the arthritic hip joint could safely reduce pain and improve movement. Thirty adults with mild to moderate hip osteoarthritis received one ultrasound-guided injection. Researchers measured changes in pa…

This study tested two different exercise programs—Blackburn stabilization and proprioceptive neuromuscular facilitation (PNF)—in 51 adults with shoulder impingement syndrome. Participants did 18 sessions over six weeks, adding these exercises to a standard routine. The goal was t…

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study tested whether custom mouthguards (splints) designed using a 3D jaw-tracking device called MODJAW work better than standard mouthguards for people with teeth grinding (bruxism) or jaw pain. 40 adults with mild-to-moderate symptoms wore either a personalized or standard…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested if using heat to destroy a nerve in the kneecap (patellar denervation) during total knee replacement surgery reduces pain and improves knee function afterward. 64 adults with knee osteoarthritis took part. The goal was to see if this extra step helps people reco…

This study looked at whether shiatsu, a type of bodywork using finger pressure, can reduce fatigue in people with axial spondyloarthritis (a form of arthritis affecting the spine). 72 adults with the condition were randomly assigned to receive shiatsu sessions or continue usual c…

This study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injec…

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study tested whether a 9-week personalized physical training program using an exercise bike could help people with ankylosing spondylitis, a type of arthritis that affects the spine. Fifty-six patients participated, and researchers measured how many achieved a meaningful imp…

This study tested whether using ultrasound to guide hyaluronic acid injections into the jaw joint works better than the usual method for people with a displaced jaw disc. Forty adults who had not improved with other treatments received either ultrasound-guided or standard injecti…

This study compared two ways to manage pain after total hip replacement: a newer ultrasound-guided nerve block (PENG block) versus standard surgical infiltration. The goal was to see which method reduces the need for strong painkillers like morphine, especially in older patients …

This study looked at whether a mix of two common injections—cortisone and hyaluronic acid—works better than cortisone alone for thumb arthritis pain. 150 adults with moderate to severe pain took part. The goal was to see if the combination provides more relief.

This completed trial tested whether kinesiologic taping (a special elastic tape) applied to the knee can reduce pain, improve mobility, and lessen fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were randomly assigned to receive either real kines…

This study tested whether injecting numbing medicine around the knee nerves can reduce pain and improve daily function in people with chronic knee osteoarthritis. 81 adults aged 45–75 received either a local anesthetic alone, a local anesthetic plus steroid, or a sham saline inje…

This study looked at whether inhaling a mixture of oxygen and nitrous oxide (sometimes called laughing gas) during physical therapy helps people with frozen shoulder. 75 adults with frozen shoulder took part. Some received the gas mix during therapy, while others inhaled a placeb…

This study tested a low-cost way to make platelet-rich plasma (PRP) from a patient's own blood for knee osteoarthritis. Twenty adults with mild to moderate knee OA received two injections of this homemade PRP. The main goal was to see if the PRP had enough platelets, similar to e…

This study tested whether adding ultrasound or kinesiotape to shoulder exercises helps people with shoulder impingement syndrome feel less pain and move better. Forty-five adults with shoulder pain for at least a month took part. They did exercises three times a week for four wee…

This phase 2 trial tested an experimental implant called ATX101 that slowly releases the numbing drug bupivacaine into the knee after total knee replacement surgery. The study involved 226 adults and compared ATX101 to a saline placebo and standard bupivacaine injections. The goa…

This study looked at whether adding Traditional Chinese Medicine (TCM) to a self-care program helps people with jaw pain (TMD). 135 adults with moderate to severe pain were given different levels of care based on how they responded. The goal was to see if TCM could improve pain a…

This study tested an 8-week mindfulness program (MBSR) in 40 adults with painful hip or knee osteoarthritis. Participants learned to focus on the present moment to better manage chronic pain. The goal was to see if mindfulness could reduce pain and improve daily function compared…

This study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movemen…

This study tested a treatment called pulsed radiofrequency, which uses gentle electrical pulses to calm the nerve that supplies most of the shoulder's feeling. It was given to 32 patients over 65 with frozen shoulder (adhesive capsulitis), a condition that causes pain and stiffne…

This study tested whether a shot of platelet-rich plasma (PRP) from a person's own blood works better than a common steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received either a PRP or steroid injection. Researchers measure…

This study tested whether giving the antibiotic teicoplanin as a shot under the skin is safe and well-tolerated in adults with bone and joint infections. Thirty patients who were already stable on IV teicoplanin received the subcutaneous version. The main goal was to check for in…

This study tested whether a fiber supplement (inulin) and/or app-based exercises could reduce knee pain in 117 adults with osteoarthritis. Participants were split into groups: placebo, diet only, exercise only, or both. The main goal was to see if pain scores improved over time. …

This study tested a device that gently stimulates a nerve in the ear to reduce pain and inflammation in people with a severe form of hand osteoarthritis. 148 participants used either the active device or a sham (fake) device daily for 12 weeks. The goal was to see if the real dev…

This study looked at 55 adults with severe frozen shoulder (pain and stiffness for at least 3 months) who had not improved with standard treatments. They received one to three injections of steroid and numbing medicine into the shoulder joint, followed by intensive physiotherapy.…

This study tested whether remote, video-call supervised exercise works as well as in-person sessions for people with knee osteoarthritis. 48 participants did muscle-strengthening exercises for 12 weeks, either via video call or at a clinic. Researchers measured pain, function, an…

This study tested whether a single ultrasound-guided injection of Botox into the thumb joint, combined with a splint, can reduce pain in people with base-of-thumb osteoarthritis. Sixty adults with moderate to severe pain received either Botox or a saline placebo injection. The ma…

This study tested whether a 2-week program of group education sessions and exercises before total knee replacement helps people recover function more quickly after surgery. 262 adults with knee osteoarthritis took part. The program included 4 education sessions and 4 exercise ses…

Knee osteoarthritis treatments vary widely, and doctors lack clear guidance on which option suits which patient. This study follows 5,000 people with knee osteoarthritis who receive usual care, recording the treatments they get and how they fare. Researchers aim to map common tre…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

Researchers at Giresun University are studying whether a blood protein called calprotectin changes in people with axial spondyloarthritis who complete a four-week pulmonary rehabilitation program. Thirty patients aged 25 to 65 will take part. The team will measure calprotectin al…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

Researchers at Nantes University Hospital are studying how joint damage from bleeding affects walking in adults with moderate hemophilia. About 24 participants will have their gait measured with motion capture and force platforms during a single visit. The study also collects cli…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study checks whether the Four Square Step Test (FSST) is a good way to measure balance in people with rheumatoid arthritis. Researchers will test 50 adults aged 18-65 with RA, comparing FSST results to other measures like disease activity, pain, and muscle strength. The goal…

Prosthetic joint infections are rare but serious, often causing long hospital stays and lasting disability. Researchers at a French hospital are asking adults with these infections to fill out standard quality-of-life questionnaires during their regular follow-up visits. The stud…

This study follows 136 adults aged 50 to 85 with knee osteoarthritis who are taking the supplement Structum (chondroitin sulfate). Researchers will measure pain, stiffness, and physical function using a standard questionnaire, along with other health factors, at the start and aft…

This observational study asks whether women with lipedema, a condition that causes abnormal fat buildup in the legs, are more likely to have joint hypermobility, or unusually loose joints, compared to healthy women of similar age and weight. Researchers will measure joint loosene…

This study looks at how your sense of joint position, fear of moving, balance, and sensory processing affect recovery after knee osteoarthritis surgery. Researchers will measure these factors in 75 people aged 50-75 who had a total knee replacement 4-6 weeks ago. The goal is to b…

This study looks at how bending the knee during exercises like squats affects pain in people with patellofemoral pain syndrome (PFPS). Fifteen participants will do three types of squats with increasing range of motion and rate their pain. The goal is to understand the relationshi…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study looks at whether using an activity tracker with motivational feedback helps people become more active after knee replacement surgery compared to using a tracker without feedback. About 152 adults aged 40-85 scheduled for knee replacement will take part. The goal is to …

This study follows adults over 60 who are having a hip replaced due to osteoarthritis. The goal is to see how the surgery affects their balance and their confidence in performing daily activities without falling. Researchers will measure balance using a detailed physical test and…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study looks at how a common jaw joint problem (TMJ disc displacement) might be connected to changes in the neck bones. Researchers will use X-rays and MRIs to measure the shape and posture of the upper neck vertebrae in 115 people with TMJ issues. The goal is to better under…

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study is observing 85 male teen athletes aged 15-17 to see how their trunk mobility, hamstring flexibility, and balance differ by sport. No treatments are given—just measurements using a digital inclinometer and balance tests. The goal is to spot physical traits that might r…

This study examines nanofat—a processed form of a person's own fat—to see if it could be used as a cell therapy for rhizarthrosis, a common and painful form of thumb osteoarthritis. Researchers will collect fat samples from healthy volunteers and analyze the cells and sterility i…

This study examined tissue samples from the shoulder capsule of 40 patients to see if certain changes are linked to shoulder instability. Researchers compared samples from patients with unstable shoulders to those without. The goal was to better understand these tissue changes, w…

This registry study collects detailed information from 45,000 adults undergoing fast-track hip or knee replacement at eight Danish hospitals. Researchers track patient health before surgery and complications afterward, including hospital stays, readmissions, and deaths within 90 …

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This study looked at 45 people with patellofemoral pain syndrome (pain around the kneecap) to see if different types of the condition have unique movement problems. Participants had X-rays and walking tests to measure how their knees move. The goal was to better understand the co…

This completed study examined 22 adolescents with idiopathic scoliosis to see if joint hypermobility (flexibility) and foot posture are linked to the severity of their spinal curve. Researchers measured hypermobility with the Beighton Score, foot posture with the Foot Posture Ind…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This completed study reviewed data from 31 patients who had knee replacement revision surgery due to aseptic loosening (the implant coming loose without infection). Researchers used a regional registry and X-ray analysis to understand the causes and economic impact. The goal was …

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study looked at whether virtual surgical planning can accurately predict the placement of custom-made jaw joint replacements in 8 patients with severe TMJ disorders, jaw defects, or recurrent joint stiffness. Researchers compared the planned position to the actual position a…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…

This pilot study looked at whether measuring arm speed in 3D can help track recovery in people with shoulder pain (subacromial pain syndrome). Thirteen adults had their shoulder movement measured before and after a standard 4-session rehab program. The goal was to see if these sp…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested whether giving general practitioners a simple, evidence-based guideline improves care for people with shoulder pain. 160 adults with shoulder pain took part in Norwegian GP clinics. Researchers measured pain, disability, and quality of life to see if the guideli…

This study used a special MRI technique to create detailed maps of the Achilles tendon in 121 adults. Researchers compared healthy volunteers to people with a type of arthritis called spondyloarthropathy, both with and without tendon pain. The goal was to better understand tendon…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study tested a device called NaviFast 6D, a miniature measuring arm used during hip replacement surgery to help surgeons check leg length and hip offset. Researchers compared measurements from the device to standard X-ray measurements in 84 adults undergoing hip replacement.…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…

This study looked at whether a team-based health assessment before knee or hip replacement surgery improves quality of life and reduces healthcare costs for patients aged 65 and older with multiple chronic conditions. 157 patients were randomly assigned to receive either usual ca…

This study looked at 50 adults having knee replacement surgery to see if a computer-guided tool (imageless navigation) can measure key knee angles as accurately as a CT scan. The tool creates a digital model of the knee during surgery, which could avoid the need for a preoperativ…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at whether measuring drug levels and anti-drug antibodies in the blood of rheumatoid arthritis patients can help doctors make better treatment decisions. 52 patients starting adalimumab or certolizumab were randomly assigned to have their test results shared wit…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different positions affect joint space measurements in people with knee osteoarthritis. 21 patients had MRI scans while standing and lying down, with their knees bent and straight. The goal was to understand how these positions change the distance between…

This study looked at 27 university students to see if a common postural problem called Upper Cross Syndrome (forward head and rounded shoulders) is linked to jaw pain and dysfunction (TMD). Researchers measured posture angles and jaw movement in a single session. No treatment was…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at knee tissue that was removed during total knee replacement surgery in 29 patients. The goal was to learn more about how knee diseases and injuries affect bone and tissue structure, and to test new ideas for future treatments like custom implants or 3D-printed…

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This study looked at whether drinking whey protein and doing simple home exercises for two weeks before hip replacement surgery helps people recover faster. Researchers measured blood markers, how soon patients could walk, and how long they stayed in the hospital. The goal is to …

This study looked at 48 young adults (24 with bruxism, or teeth grinding, and 24 without) to understand how jaw function, posture, muscle stiffness, pain, stress, and sleep quality are connected. Researchers used special tools to measure posture, muscle tightness, and pain levels…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This completed study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density in 10 patients. Researchers measured visceral fat, lean mass, and bone marrow fat before and after treatment. The goal was to gather early data, not to prove th…

This study looked at 60 people with frozen shoulder to understand how fear of movement (kinesiophobia) relates to pain, stiffness, and daily life. Participants had their shoulder motion measured and filled out questionnaires. The goal was to see if this fear makes symptoms worse,…

This study tested whether a smartphone app and a wearable activity tracker are practical and acceptable for people with inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Over 14 days, 50 participants answered short surveys on their phone and wore a …

This study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…

This study looked at 62 people with knee osteoarthritis to see which factors predict a good response to radial pressure wave therapy. Researchers analyzed data from a previous trial to find links between patient traits like age, weight, and pain levels and their improvement after…

This study looked at whether regular nurse check-ins could spot the return of rheumatoid arthritis symptoms sooner than standard doctor visits. 51 adults with controlled arthritis on rituximab took part. The goal was to see if nurses could detect early signs of a flare, potential…

This study compared shoulder muscle strength and fatigue between 60 people with frozen shoulder (adhesive capsulitis) in the recovery phase and healthy individuals. Researchers used a special machine to measure peak torque and fatigue index of shoulder muscles. The goal was to un…

This study examined whether arthritis in the hands is linked to more severe arthritis in the knees and hips. Researchers used hand X-rays to assess joint damage in 479 adults aged 40 to 75 with confirmed knee or hip arthritis. The goal was to better understand how arthritis progr…

This pilot study tested whether wearable sensors (Syde devices) can reliably track knee osteoarthritis symptoms at home over two months. 43 participants wore the sensors on their ankles and wrists to record movement data, which was compared with standard clinic tests. The goal wa…

This pilot study tested whether a transition coach can help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult care. The coach met with each teen for 8 one-hour sessions covering self-advocacy, medication management, and …

This study followed 708 adults with early inflammatory back pain for up to 5 years. Researchers collected data to better understand how the disease progresses, what predicts joint damage, and how to improve diagnosis. The goal was to gather knowledge, not to test a new treatment.

This completed study tested whether training rheumatology clinicians in shared decision making helps veterans with rheumatoid arthritis. About 900 patients from VA clinics took part. The training taught doctors to acknowledge treatment options and involve patients in choices. Res…

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at 60 university students aged 18-25 to see if those with temporomandibular joint disorder (TMD) have different neck muscle endurance and pain sensitivity compared to healthy students. Researchers measured how long students could hold neck exercises and how much…

This completed study looked at 84 adults with knee osteoarthritis to see how common fear of movement (kinesiophobia) is and how it relates to pain and daily function. Researchers measured fear, pain, and physical ability using standard questionnaires. The goal was to understand i…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study tested whether custom carbon fiber braces can reduce harmful forces on the ankle joint after a fracture, which may lower the risk of developing arthritis. Twenty-two adults with healed ankle fractures walked with and without different brace designs while researchers me…

This study followed 432 people who had ACL reconstruction surgery to see who develops osteoarthritis years later. Researchers measured knee joint space on x-rays and looked at injury details, surgical factors, and patient traits. The goal is to identify risk factors that could he…

This study followed 472 adults aged 18-75 who received a specific type of hip replacement to see how long the implants lasted. Researchers used patient surveys and survival curves to measure device performance. The goal was to gather long-term data, not to test a new treatment.

This study looked at whether different digital bite recording methods affect how well Michigan splints (mouthpieces for jaw pain) fit. Ten adults with jaw disorders each had four splints made using different digital workflows. Researchers measured how much adjustment was needed t…

This study looked at how the drug methotrexate and its main byproduct leave the body in people with rheumatoid arthritis. Researchers measured levels in urine to create a reference range. This could help doctors identify patients who are not taking their medication as prescribed.

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…

This study tested four different cuff designs for carbon fiber ankle-foot orthoses (braces) in 35 healthy adults and people with ankle arthritis or injury. Researchers measured comfort, pain, foot pressure, and walking mechanics to see which cuff design people liked best. The goa…

This study looked at whether a common jaw joint disorder (anterior disc displacement with reduction) affects pain after root canal treatment. 70 adults with tooth infection and jaw pain were treated and tracked their pain for a week. The goal is to see if dentists should consider…

This study looked at fatigue in 33 adults with psoriatic arthritis or psoriasis. Researchers used questionnaires to measure tiredness and see how it relates to disease severity and treatments. The goal was to better understand fatigue and its impact on quality of life.

This study followed 135 people who received a specific type of hip replacement implant (SL-PLUS MIA stem) for up to 10 years. The goal was to see how long the implant lasts, check for problems like loosening or infection, and track X-ray changes. Participants had standard follow-…

This completed study surveyed 229 people with chronic inflammatory rheumatism (like rheumatoid arthritis) and their doctors to find out what makes it hard to follow care recommendations after a hospital visit. The goal was to identify barriers to good outpatient management. No tr…

This study followed 41 patients who received a scaffold implant for partial meniscal tears in the knee. Researchers collected data from telephone surveys and medical records to see how well patients were doing over time. The goal was to understand if this treatment helps with pai…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This study looked at whether MRI scans can reliably find a torn disc in the jaw joint (temporomandibular joint). Researchers reviewed MRI images and medical records from 282 people to see how often disc tears occur and how they relate to pain, disc shape, and bone changes. The go…

This study looks at how common muscle loss (sarcopenia) is in people with spondylarthropathy, a type of inflammatory arthritis. Researchers will measure muscle strength, walking speed, and body composition in 106 adults. The goal is to better understand and detect this disabling …

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This completed study looked at the safety of the arthritis drug abatacept in over 38,000 people with rheumatoid or psoriatic arthritis in Denmark. Researchers used a national health registry to track rates of cancers and other side effects. The goal was to better understand the d…

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study looked back at records of 67 children to see if a broken front tooth from an injury could lead to hidden changes in the jaw joint. Researchers used special 3D X-rays (CBCT) to measure joint spaces and check for pain. They found that children with tooth fractures had di…

This study looked at whether preserving or removing the infrapatellar fat pad (a small pad of fat in the knee) during total knee replacement leads to better outcomes for people with knee osteoarthritis. Over 370 participants were randomly assigned to one of two groups. Researcher…

This study looked at 20 older women with knee arthritis to see if having different strength in each leg affects their balance, walking, and daily activities. Researchers measured leg muscle strength and tested how well participants could stand up from a chair and walk. The goal w…

This completed study reviewed the medical charts of 32 people with Still's disease who developed a serious complication called macrophage activation syndrome (MAS). The goal was to learn more about their symptoms, how long it took for lab values to return to normal, and what trea…

This study tests a portable ultrasound device that measures pelvic tilt, which is important for planning hip replacement surgery. Researchers will check how consistent the measurements are by repeating them on 3 healthy volunteers and then measure pelvic tilt in 30 patients befor…

This study aimed to learn how Charcot foot, a serious but poorly understood diabetes complication, is currently diagnosed and treated in specialized foot centers across France and Belgium. Researchers collected information from over 1,100 patients to identify common practices and…

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …

This study looked at the gut bacteria of 55 people—some newly diagnosed with rheumatoid arthritis and some without the disease. Researchers wanted to see if certain bacteria are more common in arthritis patients. The goal is to better understand how gut health might be linked to …

This completed study looked at 126 children with juvenile idiopathic arthritis to find the best dose of the drug etanercept. Researchers measured drug levels in the blood and checked how well the disease was controlled. The goal is to help doctors give each child the right amount…

This study looked at 192 people aged 50-85 with knee arthritis who needed knee replacement surgery. Half had computer-navigated surgery and half had the traditional technique. The goal was to see if computer guidance helps the new knee last longer, improves function, or reduces c…

This study compared how well an AI chatbot (ChatGPT) answered common questions from people with knee or hip osteoarthritis versus answers from real doctors. 286 patients rated the responses for preference, length, and difficulty. The goal was to see if AI could provide acceptable…

This study looked at whether physical rehabilitation after hip or knee replacement surgery is better than no rehabilitation for helping people with daily activities like walking and getting in and out of a car. 169 adults who had hip or knee replacement due to osteoarthritis took…

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This study looked at 30 people with hip pain caused by a condition called ischiofemoral impingement, where the hip bones pinch soft tissues. Researchers wanted to see if ultrasound measurements of the hip space and muscle thickness match up with MRI scans, which are the current s…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…

This study tested whether a questionnaire called the Rheumatoid Arthritis Impact of Disease (RAID) could help doctors make better decisions during virtual consultations. 70 patients with rheumatoid arthritis participated. The goal was to see if using this tool reduced the need fo…

This study looked at 44 people with shoulder pain from rotator cuff tears to see if a condition called central sensitization (where the nervous system is extra sensitive to pain) changes how well a steroid injection works. Participants got a shot of betamethasone and prilocaine i…

This completed trial looked at whether a center focused on standard care for rheumatoid arthritis (RA) can improve how patients manage their disease. Nearly 1,000 adults with stable RA took part. The study tested two things: a nurse visit to check for and treat common RA-related …