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Can a once-daily pill tame psoriatic arthritis in everyday life?

NCT ID NCT05616871

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in routine care. The goal is to understand real-world effectiveness, not just results from controlled trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
upadacitinib (RINVOQ), taken alone or with methotrexate
What this could lead to
If successful, this study could confirm that upadacitinib works well in everyday clinical practice for people with active psoriatic arthritis.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. Upadacitinib carries risks like infection and blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

464 people

The number who actually took part.

Started

Dec 2022

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult participants with Psoriatic Arthritis (PsA)

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed diagnosis of active psoriatic arthritis (PsA) whose peripheral involvement justifies the prescription of upadacitinib upon judgement of the treating physician. * Physician decision on participant treatment with upadacitinib must have been reached prior to and independently of recruitment in the study. * Upadacitinib prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies. * Participants able to understand and communicate with the investigator and comply with the requirements of the study. Exclusion Criteria: * Participation in a clinical trial of an investigational drug, concurrently or within the last 30 days. * Prior treatment with upadacitinib.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psoriatic arthritis

Contacts and locations

Locations

  • 251 Airforce General Hospital /ID# 248092

    Athens, Attica, 11525, Greece

  • AP-HP - Groupe Hospitalier 10e - Hopital Lariboisiere /ID# 252526

    Paris, 75010, France

  • AP-HP - Hopital Bichat - Claude-Bernard /ID# 252531

    Paris, 75018, France

  • AP-HP - Hopital Saint-Antoine /ID# 252627

    Paris, 75012, France

  • ASU FC - P.O. Universitario Santa Maria della Misericordia /ID# 251544

    Udine, 33100, Italy

  • Aurich and Sieburg, Magdeburg /ID# 255504

    Magdeburg, Saxony-Anhalt, 39104, Germany

  • Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 251183

    Naples, Napoli, 80138, Italy

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone /ID# 250789

    Palermo, 90127, Italy

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 250817

    Rome, Roma, 00133, Italy

  • Azienda Ospedaliera Universitaria Senese /ID# 251146

    Siena, 53100, Italy

  • Azienda Ospedaliero Universitaria delle Marche /ID# 250819

    Ancona, 60126, Italy

  • Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari /ID# 251508

    Bari, 70124, Italy

  • Beyer, Kaiserslautern, DE /ID# 254754

    Kaiserslautern, Rhineland-Palatinate, 67659, Germany

  • Bioclinic Thessaloniki /ID# 247648

    Thessaloniki, 54622, Greece

  • C. H. Sud Francilien /ID# 254945

    Corbeil-Essonnes, 91106, France

  • CH AIX LES BAIN - Reine Hortense /ID# 252465

    Aix-les-Bains, 73100, France

  • CH Henri Duffaut /ID# 252620

    Avignon, Vaucluse, 84902, France

  • CH La Rochelle - Hopital Saint Louis /ID# 252534

    La Rochelle, 17019, France

  • CH de Cannes - Simone Veil /ID# 252600

    Cannes, 06400, France

  • CH de Narbonne /ID# 252525

    Narbonne, 11100, France

  • CHRU Tours - Hopital Trousseau /ID# 252528

    Chambray-lès-Tours, 37170, France

  • CHU Bordeaux - Hopital Pellegrin /ID# 252532

    Bordeaux, New Aquitaine, 33076, France

  • CHU Grenoble - Hopital Michallon /ID# 252601

    La Tronche, Isere, 38700, France

  • CHU Limoges - Dupuytren 1 /ID# 252432

    Limoges, Franche-Comte, 87042, France

  • CHU Montpellier - Hopital Saint Eloi /ID# 252078

    Montpellier, Herault, 34295, France

  • CHU Toulouse - Hopital Purpan /ID# 252077

    Toulouse, Haute-Garonne, 31059, France

  • CHU de Rennes - Hospital Sud /ID# 252478

    Rennes, 35203, France

  • Cabinet Du Dr Judith Payet Dubourg /Id# 252668

    Saint-Pierre-des-Corps, 97410, France

  • Cabinet Medical Dr Albert-Sabonnadiere - Antibes /ID# 252523

    Antibes, Provence-Alpes-Côte d'Azur Region, 06000, France

  • Cabinet libéral du Dr PAUPIERE /ID# 252604

    Péronne, Somme, 80200, France

  • Centre Hospitalier Jean Rougie /ID# 259550

    Cahors, 46005, France

  • Centre Hospitalier Regional d Orleans - Hopital de la Source /ID# 252530

    Orléans, 45067, France

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 252536

    Nice, Alpes-Maritimes, 06001, France

  • Centre Hospitalier d'Arras /ID# 252529

    Arras, 62022, France

  • Centre Hospitalier de Boulogne Sur Mer /ID# 252467

    Boulogne-sur-Mer, 62200, France

  • Ch Beauvais /Id# 252464

    Beauvais, Oise, 60021, France

  • Chic Castres-Mazamet /Id# 259557

    Castres, Tarn, 81108, France

  • Clinique Médipôle Garonne /ID# 252462

    Toulouse, 31036, France

  • Clinique de la Sauvegarde /ID# 252533

    Lyon, 69009, France

  • Dr. Bolze, Ludwigshafen, DE /ID# 254134

    Ludwigshafen, 67069, Germany

  • Dr. Murawski /ID# 257911

    Neunkirchen, Saarland, 66538, Germany

  • Duplicate_CH Troyes - Hopital Simone Veil /ID# 252625

    Troyes, Aube, 10000, France

  • Duplicate_CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 259549

    La Roche-sur-Yon, Vendee, 85000, France

  • Duplicate_CHU Amiens-Picardie Site Sud /ID# 252527

    Amiens, Somme, 80054, France

  • Duplicate_CHU de Besancon - Jean Minjoz /ID# 252537

    Besançon, Doubs, 25030, France

  • ELSAN - Clinique du Pont de Chaume /ID# 252602

    Montauban, 82000, France

  • Euromedica Blue Cross Gen Clin /ID# 251898

    Thessaloniki, 54636, Greece

  • Euromedica General Clinic /ID# 251897

    Thessaloniki, 54645, Greece

  • Fondazione IRCCS Policlinico San Matteo /ID# 250747

    Pavia, 27100, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 250669

    Rome, Roma, 00168, Italy

  • GH Diaconesses Croix Saint-Simon /ID# 252463

    Paris, 75020, France

  • General Hospital of Athens Gennimatas /ID# 247635

    Athens, Attica, 11527, Greece

  • General Hospital of Athens Ippokratio /ID# 247633

    Thessaloniki, Attica, 11527, Greece

  • General Hospital of Athens Laiko /ID# 247634

    Athens, Attica, 11527, Greece

  • General Hospital of Athens Laiko /ID# 258030

    Athens, Attica, 11527, Greece

  • General Hospital of Elefsina Thriassio /ID# 251900

    Magoula (Attikis), Attica, 19018, Greece

  • General Hospital of Thessaloniki Hippokrateio /ID# 247643

    Thessaloniki, 54642, Greece

  • Henry Dunnant Hospital Center /ID# 247640

    Athens, Attica, 11526, Greece

  • Hopital St Joseph - St Luc (Lyon) /ID# 259561

    Lyon, 69007, France

  • Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 245194

    Créteil, Paris, 94010, France

  • Hôpital Charles-Nicolle /ID# 252603

    Rouen, 76000, France

  • IRCCS Istituto Clinico Humanitas /ID# 251275

    Rozzano, Lombardy, 20089, Italy

  • IRCCS Ospedale San Raffaele /ID# 251562

    Milan, Milano, 20132, Italy

  • Iaso /ID# 247649

    Marousi, Attica, 15123, Greece

  • Iaso Thessalias /ID# 255110

    Larissa, Larisa, 41500, Greece

  • Infirmerie Protestante De Lyon /ID# 252075

    Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300, France

  • KAT Atttica General Hospital /ID# 247641

    Athens, 14561, Greece

  • Knappschaftsklinikum Saar /ID# 255505

    Püttlingen, 66346, Germany

  • Krankenhaus St. Josef /ID# 254755

    Wuppertal, 42105, Germany

  • Krankenhaus der Barmherzigen Brüder Trier /ID# 254762

    Trier, Rhineland-Palatinate, 54292, Germany

  • Kupka and Kupka, Altenburg, DE /ID# 254758

    Altenburg, Thuringia, 04600, Germany

  • MVZ Ambulantes Rheumazentrum Erfurt /ID# 256115

    Erfurt, Thuringia, 99096, Germany

  • MVZ Herzogin Elisabeth Hospital /ID# 266740

    Braunschweig, 38114, Germany

  • Naval Hospital of Athens /ID# 247631

    Athens, 11521, Greece

  • Olympion General Clinic /ID# 247644

    Pátrai, Achaia, 26443, Greece

  • Praxis Dilltal /ID# 254761

    Ehringshausen, 35630, Germany

  • Praxis Dr. Silke Zinke /ID# 258037

    Berlin, 13055, Germany

  • Private Practice - Dr. Hauke E. Heintz /ID# 254757

    Hamburg, 22391, Germany

  • Prof-med-stud.de /ID# 265965

    Munich, 80935, Germany

  • RHIO Forschungsinstitut /ID# 254752

    Meerbusch, 40668, Germany

  • Reg Gen Univ Hosp Larissa /ID# 247642

    Larissa, 41110, Greece

  • Rheumapraxis Dr. Prothmann /ID# 254759

    Püttlingen, Saarland, 66346, Germany

  • Rheumatologische Schwerpunktpraxis Brandt-Juergens /ID# 258152

    Berlin, 12161, Germany

  • Rheumazentrum Ruhrgebiet /ID# 252939

    Herne, North Rhine-Westphalia, 44649, Germany

  • Universita degli Studi del Molise /ID# 251176

    Campobasso, 86100, Italy

  • Universitaetsmedizin Greifswald /ID# 254756

    Greifswald, 17475, Germany

  • University General Hospital Attikon /ID# 248093

    Chaïdári, Attica, 12462, Greece

  • University General Hospital of Heraklion PA.G.N.I /ID# 247632

    Heraklion, Crete, 71500, Greece

  • University General Hospital of Ioannina /ID# 251899

    Ioannina, 45500, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.