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Scientists compare bone marrow and belly fat to uncover osteoarthritis clues

NCT ID NCT03678831

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contributes to osteoarthritis and find new treatment targets.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new treatments for osteoarthritis by targeting harmful fat signals.
What could go wrong
This is a small, completed observational study that only looks at fat cell differences, not testing any treatment. Results may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

45 people

The number who actually took part.

Started

Jun 2020

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Arthritic post-menopausal patients with knee prosthetic replacement

Ages

18 to 85 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Post-menopausal woman * with a symptomatic knee osteoarthritis requiring prosthesis * able to handle general anaesthesia * having given her consent * able to understand the constraints associated with the study * with health insurance * able to understand the French language Exclusion Criteria: * with refusal to participate to the study * more than 85-year-old * with bone pathologies other than osteoarthritis or osteoporosis * with active infection * with evolving cancer * with haematopoietic pathologies such as haemoglobin pathologies * with thyroid pathologies * with type 1 diabetes * with anti-osteoporotic treatments (bisphosphonates, strontium ranelate, teriparatide, denosumab) except calcium and vitamin D supplementation or hormone replacement. * with replacement of prosthesis * with previous surgery at the surgery site --with a current participation to another study * with guardianship * with deprived liberty

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Conditions

The condition(s) this trial relates to.

Obesity osteoarthritis osteoarthritis, knee type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee Prosthesis user

Contacts and locations

Locations

  • Hopital Roger Salengro, CHU Lille

    Lille, 59037, France

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