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Can a common arthritis drug ease hand pain? new trial tests methotrexate

NCT ID NCT01068405

Disease control Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measured pain levels and overall well-being to see if methotrexate offers a new treatment option for this painful condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Methotrexate
What this could lead to
If it works, this could point toward a treatment option for painful hand arthritis where none currently exists.
What could go wrong
This is a small, completed trial with only 64 participants. Methotrexate may not reduce pain or improve quality of life more than placebo, and it can cause side effects like nausea or liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

64 people

The number who actually took part.

Started

May 2010

Finished

Oct 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * hand arthritis * pain over 40/100 * stable treatment since 4 weeks at least with non-steroid analgesic * between 45 et 85 years Exclusion Criteria: * pregnancy or breast feeding women * hyaluronic acid injection within the past 6 months * cortisonic derivated injection within the past 3 months

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis, hand polyarticular arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polyarthritis

Contacts and locations

Locations

  • Nice University Hospital, Rheumatology Department

    Nice, 06000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.