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New knee implant tracked for 5 years in 777 patients

NCT ID NCT02337244

Disease control Sponsor: Zimmer, GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 777 adults aged 18-75 who received the Persona Total Knee System to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers will track how long the implant lasts, how safe it is, and how well it improves pain and function over 5 years. The goal is to gather real-world data on the implant's performance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Zimmer Persona Total Knee System (artificial knee implant)
What this could lead to
If successful, this could confirm that the Persona knee implant provides long-lasting pain relief and improved function for people with severe knee arthritis.
What could go wrong
This is an observational study, not a controlled trial, so results may not prove the implant is better than other options. Some patients may still experience complications like implant loosening or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

777 people

The number who actually took part.

Started

Nov 2013

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Primary total knee arthroplasty subjects that receive the Zimmer Persona Total Knee System.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient 18-75 years of age, inclusive. * Patient qualifies for primary total knee arthroplasty based on physical exam and medical history, including diagnosis of severe knee pain and disability due to at least one of the following: * rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis; * collagen disorders and/or avascular necrosis of the femoral condyle; * post-traumatic loss of joint configuration, particularly when there is patellofemoral erosion, dysfunction or prior patellectomy; * moderate valgus, varus, or flexion deformities; * the salvage of previously failed surgical attempts that did not include partial or total knee arthroplasty of the ipsilateral knee. * Patient is willing and able to complete scheduled study procedures and follow-up evaluations. * Independent of study participation, patient is a candidate for commercially available Zimmer Persona knee implants implanted in accordance with product labeling. Exclusion Criteria: * Patient is currently participating in any other surgical intervention studies or pain management studies. * Previous history of infection in the affected joint and/or other local/systemic infection that may affect the prosthetic joint. * Insufficient bone stock on femoral or tibial surfaces. * Skeletal immaturity. * Neuropathic arthropathy. * Osteoporosis or any loss of musculature or neuromuscular disease that compromises the affected limb. * Stable, painless arthrodesis in a satisfactory functional position. * Severe instability secondary to the absence of collateral ligament integrity. * Rheumatoid arthritis accompanied by an ulcer of the skin or a history of recurrent breakdown of the skin. * Patient has a known or suspected sensitivity or allergy to one or more of the implant materials. * Patient is pregnant or considered a member of a protected population (e.g., prisoner, mentally incompetent, etc.). * Patient has previously received partial or total knee arthroplasty for the ipsilateral knee.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis polyarticular arthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis Polyarthritis Rheumatoid arthritis Severe knee disability Severe knee pain Traumatic arthritis

Contacts and locations

Locations

  • Atos Klinik Heidelberg

    Heidelberg, Germany

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, 63003, France

  • Centre Hospitalier régional Universitaire de Montpellier

    Montpellier, 34980, France

  • Golden Jubilee National Hospital

    Clydebank, United Kingdom

  • HEH Braunschweig

    Braunschweig, Germany

  • Harrogate and District NHS

    Harrogate, HG2 7SX, United Kingdom

  • Hospital Miguel Servet

    Zaragoza, Spain

  • Hospital Parc Tauli

    Sabadell, Spain

  • Orthopädisches Spital Speising

    Vienna, 1130, Austria

  • Stichting Research Orthopedie & Reinier de Graaf Groep

    Delft, 2612, Netherlands

  • The Newcastle Upon Tyne Hospitals

    Newcastle, United Kingdom

  • University of Leeds

    Leeds, Leeds/UK, LS2 9JT, United Kingdom

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