Which surgery better fixes a collapsed spine? a Head-to-Head test
NCT ID NCT07724236
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small screws to stabilize the spine. By reviewing records of 60 patients, the study asks whether one approach leads to better pain relief and spinal alignment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cement-augmented short-segment percutaneous pedicle screw fixation or percutaneous vertebroplasty
- What this could lead to
- If one technique proves superior, it could guide surgeons toward a more effective treatment for this painful spinal condition.
- What could go wrong
- This is a small retrospective study, not a randomized trial, so results may be influenced by patient selection. Both procedures carry risks of cement leakage or implant failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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60 people
The number who actually took part.
- Started
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Nov 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This retrospective study includes 60 patients diagnosed with stage II KD with single-level involvement, who failed conservative treatment for ≥6 weeks. All patients had complete preoperative and postoperative clinical/imaging data with at least 3 months of follow-up. Patients were divided into two groups: PVP alone (n=30) and combined procedure (vertebral augmentation with short-segment percutaneous cement-augmented pedicle screw fixation, n=30). Exclusion criteria: multilevel lesions, prior lumbar surgery, spinal infection, uncontrolled hypertension, diabetes, severe cardiopulmonary/hepatic/renal dysfunction, endocrine disorders, immunodeficiency/malignancy, psychiatric/cognitive impairment, or participation in drug trials within 6 months.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients with imaging findings consistent with stage II KD and corresponding clinical symptoms and signs; 2. All cases involve single-level lesions; 3. Individuals who have shown no improvement or experienced symptom progression after more than 6weeks of conservative treatment; 4. Patients with complete clinical and imaging data before and after surgery; 5. Those who were followed up for at least 3 months postoperatively. Exclusion Criteria: 1. Patients with multilevel lumbar spondylolisthesis; 2. Individuals with a history of previous lumbar spine surgery; 3. Patients with spinal infection; 4. Individuals with uncontrolled hypertension; 5. Patients with uncontrolled diabetes mellitus; 6. Those with severe impairment of cardiac, pulmonary, liver, or kidney function; 7. Patients with gonadal diseases, adrenal diseases, parathyroid diseases, thyroid diseases, and pituitary disorders; 8. Individuals with a history of immunodeficiency diseases (such as HIV), cancer or malignant tumors, autoimmune diseases, severe cardiovascular or cerebrovascular diseases, or other conditions that may significantly reduce life expectancy; 9. Patients who have participated in any drug clinical trial within the last six months before screening; 10. Individuals with a clear history of mental illness or cognitive impairment who are unable to cooperate with follow-up and efficacy assessments; 11. Patients deemed unsuitable for participation in this study by the researchers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital of Guanazhou University of Traditional Chinese Mledicine
Guangzhou, Guangdong, 510405, China