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New cream aims to cut opioid use after knee surgery

NCT ID NCT06202989

Symptom relief Sponsor: KAZM Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The goal is to see if the cream improves pain scores and satisfaction while lowering opioid use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

306 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (18+) * Undergoing Primary Elective TKA * Provide informed consent Exclusion Criteria: * Administration of any investigational drug in the period of 0 to 45 days before entry into the study * Pregnancy * Actively breastfeeding * Unable to provide informed consent (e.g. cognitive disability) * Unable or unwilling to follow study protocol (e.g. unwilling to apply the topical treatments as instructed) * Have a known allergy to ketoprofen, other NSAIDs, baclofen, amitriptyline, or lidocaine, any of the study drugs or their ingredients * Have a history of substance abuse * Use daily opioids (other than short acting codeine) for a chronic pain condition other than knee OA * Are undergoing a revision TKA or are scheduled for a simultaneous bilateral TKA * Any other condition which, in the opinion of the investigators, is likely to interfere with the successful collection of the measures required for the study * Diagnosis of uncontrolled hypertension * Diagnosis of active peptic ulcer disease * A history of chronic (\> 3 months) anticoagulant usage * History of impaired kidney or liver function * Have open wounds/cuts and/or skin conditions on the knee area, other than the surgical incision * Body Mass Index (BMI) \> 50kg/m2

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postsurgical pain

Contacts and locations

Locations

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.