New cream aims to cut opioid use after knee surgery

NCT ID NCT06202989

Recruiting now Symptom relief Sponsor: KAZM Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jan 04, 2026 · Last updated Jun 02, 2026 · Updated 30 times

Summary

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The goal is to see if the cream improves pain scores and satisfaction while lowering opioid use.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Oakville Trafalgar Memorial Hospital
NOT_YET_RECRUITING

Oakville, Ontario, L6M 0L8, Canada

Contact Phone: •••-•••-••••
St. Joseph's Healthcare Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTSURGICAL PAIN