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Laughing gas may help frozen shoulder patients move better during therapy

NCT ID NCT01087229

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether inhaling a mixture of oxygen and nitrous oxide (sometimes called laughing gas) during physical therapy helps people with frozen shoulder. 75 adults with frozen shoulder took part. Some received the gas mix during therapy, while others inhaled a placebo. The goal was to see if the gas improved shoulder movement and reduced pain compared to therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
equimolar oxygen-nitrous oxide mixture
What this could lead to
If it works, this could offer a simple way to make physical therapy less painful and more effective for frozen shoulder.
What could go wrong
This is a small, completed Phase 4 trial with only 75 participants. The gas mix may not provide meaningful improvement over placebo, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

75 people

The number who actually took part.

Start date

Mar 2010

Finished

Sep 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Affiliated with a social security system * Has signed the consent form * Patient has a painful, or initially painful but stable frozen shoulder (adhesive capsulitis): stiffening characterized by a passive loss of amplitude on three planes. This loss of amplitude is greater than or equal to 50% of controlateral amplitude when the controlateral shoulder is considered as normal. Otherwise, the loss of amplitude is greater than or equal to 50% of normal anatomical values. * Radiography confirms the integrity of the glenohumeral interspace. Exclusion Criteria: * Intercurrent, evolving or unstable pathology: cancer, advanced cardio-vascular pathology, severe infection * The patient is taking a treatment that may interfere with the study (eg corticoids, pain killers, chemotherapy) * Contra-indication for physical therapy * Coagulopathy * Advanced diabetes mellitus, with neurological or joint complications * Contra indication for the experimental treatment * Pregnant or nursing women * Patient's mental state prevents him/her from understanding the nature of the study, its objectives and potential consequences. * Patient under guardianship * Patient is in an exclusion period determined by a previous study * Patient not able to follow protocol constraints or timetable * Medical history of local infection, polyarthritis or neuropathy that might explain the shoulder pain. * Absence of radiculopathy of cervical origin, of rotator cuff tears or evolving shoulder tendinopathy, of severe omarthrose

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adhesive capsulitis

Contacts and locations

Locations

  • CHU Lapeyronie

    Montpellier, 34295, France

  • CHU de Clermont Ferrand

    Clermont-Ferrand, 63118, France

  • Centre Hospitalier Universitaire de Nîmes

    Nîmes, Gard, 30029, France

  • Centre Hélio Marin

    Vallauris, 06223, France

  • Unité Rééducation Réadaptation Locomotrice

    Le Grau-du-Roi, Gard, 30240, France

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