Laughing gas may help frozen shoulder patients move better during therapy

NCT ID NCT01087229

Completed Symptom relief Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether inhaling a mixture of oxygen and nitrous oxide (sometimes called laughing gas) during physical therapy helps people with frozen shoulder. 75 adults with frozen shoulder took part. Some received the gas mix during therapy, while others inhaled a placebo. The goal was to see if the gas improved shoulder movement and reduced pain compared to therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: equimolar oxygen-nitrous oxide mixture
What this could lead to: If it works, this could offer a simple way to make physical therapy less painful and more effective for frozen shoulder.
What could go wrong: This is a small, completed Phase 4 trial with only 75 participants. The gas mix may not provide meaningful improvement over placebo, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHESIVE CAPSULITIS

Contacts and locations

Locations

CHU Lapeyronie

Montpellier, 34295, France
CHU de Clermont Ferrand

Clermont-Ferrand, 63118, France
Centre Hospitalier Universitaire de Nîmes

Nîmes, Gard, 30029, France
Centre Hélio Marin

Vallauris, 06223, France
Unité Rééducation Réadaptation Locomotrice

Le Grau-du-Roi, Gard, 30240, France

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