Laughing gas may help frozen shoulder patients move better during therapy
NCT ID NCT01087229
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether inhaling a mixture of oxygen and nitrous oxide (sometimes called laughing gas) during physical therapy helps people with frozen shoulder. 75 adults with frozen shoulder took part. Some received the gas mix during therapy, while others inhaled a placebo. The goal was to see if the gas improved shoulder movement and reduced pain compared to therapy alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
equimolar oxygen-nitrous oxide mixture
What this could lead to
If it works, this could offer a simple way to make physical therapy less painful and more effective for frozen shoulder.
What could go wrong
This is a small, completed Phase 4 trial with only 75 participants. The gas mix may not provide meaningful improvement over placebo, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Lapeyronie
Montpellier, 34295, France
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CHU de Clermont Ferrand
Clermont-Ferrand, 63118, France
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Centre Hospitalier Universitaire de Nîmes
Nîmes, Gard, 30029, France
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Centre Hélio Marin
Vallauris, 06223, France
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Unité Rééducation Réadaptation Locomotrice
Le Grau-du-Roi, Gard, 30240, France