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Can therapy and exercise boost knee replacement results?

NCT ID NCT03771430

Symptom relief Sponsor: Lovisenberg Diakonale Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exercise, surgery followed by CBT and exercise, or surgery with standard care. The main goal is to measure changes in knee pain using a patient questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive behavioral therapy and exercise
What this could lead to
If successful, this could show that combining therapy and exercise with surgery reduces pain and improves recovery for knee osteoarthritis patients.
What could go wrong
This is a mid-sized trial, and the benefits may not apply to all patients. The added therapy may not significantly improve outcomes over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

282 people

The number who actually took part.

Started

Aug 2019

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Scheduled for TKA for OA at Lovisenberg, Oslo; Martina Hansen, Bærum, or Coastal Hospital Hagevik, Bergen 2. Age 18 - 79 years 3. ASA grade 1-3 4. KL grade 3 or 4 5. BMI\<40 6. Able to read and write in Norwegian Exclusion Criteria: * Diagnosis of dementia or sero-positive rheumatic disease * Previously undergone uni or patellofemoral prosthesis in the index knee * Large axis deviation or instability requiring use of hinged implants * Scheduled for unicompartmental arthroplasty or revision surgery

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Degenerative joint disease of knee Osteoarthritis; primary

Contacts and locations

Locations

  • Haukeland University Hospital - Kysthospitalet Hagevik

    Bergen, Norway

  • Lovisenberg Diaconal Hospital

    Oslo, Norway

  • Martina Hansens Hospital

    Oslo, Norway, Norway

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