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Can a shot in the other knee ease pain after replacement?

NCT ID NCT06809998

Symptom relief Sponsor: Unity Health Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee replacement. Participants will be randomly assigned to receive either the steroid injection or a placebo in their other knee, and neither they nor their doctors will know which they received.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients 18 years of age and older * Primary osteoarthritis diagnosis with indication for primary elective unilateral TKA * No previous contralateral knee injections (steroids/biologics) within one year of study * Not scheduled for bilateral TKA or a subsequent staged contralateral TKA within the next six months * No previous or active infection or trauma (osseous/ligamentous/extensor mechanism) on the contralateral knee * Contralateral knee pain \& symptoms - defined as a VAS of \>4/10 at initial pre-op visit * Contralateral knee OA quantified as: Kellgren and Lawrence grade \>2-4 * Assessed by PI (AK) who will not be contributing any patients to the study through examination of blinded knee radiographs (3 views: AP/lateral/Sunrise) * Patient is able to read and understand English and provide informed consent to participation in the study Exclusion Criteria: * Other aetiologies of OA that warrants TKA (inflammatory or post traumatic arthritis) * Cognitive impairment (dementia, Alzheimer's, uncontrolled delirium) which will prevent patients from completing primary outcome measure or comply with follow-up requirements * Previous TKA or ORIF or nailing on either knee * Previous or active knee infection or extensor mechanism disruption * Previous arthroscopy on either knee * Medical contraindication to elective TKA surgery

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bilateral knee osteoarthritis Osteoarthritis (OA) of the knee Osteoarthritis; primary Total knee anthroplasty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • St. Michael's Hospital

    RECRUITING

    Toronto, Ontario, M5B 1W8, Canada

More trials for these conditions

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