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Jaw pain relief? PRP and hyaluronic acid injections show promise in small study

NCT ID NCT07643402

Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 09, 2026 · Updated 6 times

Summary

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure changes in movement, pain, and how wide they could open their mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) and hyaluronic acid
What this could lead to
If it works, this could offer a non-surgical option to reduce jaw pain and improve mouth opening for people with jaw joint problems.
What could go wrong
This was a small, completed study with only 22 people and no control group. Results may not apply to everyone, and injections can cause temporary soreness or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jul 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. The patients' ages range from 18 to 45. 2. Patients experienced clicking sounds, painful joints, and restricted mouth opening. 3. Individuals whose MRI confirms a unilateral internal abnormality with reduction. 4. A patient who did not respond to conservative treatment. 5 • The patient's capacity and willingness to finish the course of therapy and subsequent appointments. Exclusion Criteria 1. A patient suffering from a connective tissue or inflammatory condition. 2. A patient who has had TMJ surgery in the past. 3. A history of injecting any kind of material into the target TMJ. 4. Drug allergy history. 5. A patient who has previously had fibrous or bony adhesion. 6. A patient experiencing psychological issues.

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Conditions

The condition(s) this trial relates to.

fatal familial insomnia temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disc displacement with reduction Temporomandibular joint disc displacement, with reduction

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura university

    Al Mansurah, Dakahlia Governorate, 35516, Egypt

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