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Can a 10-Second thigh squeeze ease knee arthritis pain?

NCT ID NCT07445568

Symptom relief Sponsor: Universidad del Valle de México, Campus Cuernavaca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-cost approach is safe and effective enough to study further.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Home-based quadriceps isometric exercise
What this could lead to
If this works, it could offer a simple, low-cost way for older adults to manage knee pain at home without needing supervised rehab.
What could go wrong
This is a small pilot study with only 50 participants, so results may not apply to everyone. The exercise program is short (28 days), and long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Sep 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 65 years or older Clinical diagnosis of chronic knee osteoarthritis according to American College of Rheumatology criteria Knee pain for ≥3 months Baseline knee pain intensity ≥4 on a 10-cm Visual Analog Scale (VAS) Ability to walk independently with or without assistive devices Ability to understand study procedures and provide written informed consent Exclusion Criteria: * Recent knee surgery or intra-articular injection within the last 3 months Planned knee surgery during the study period Severe neurological or cardiovascular conditions limiting exercise participation Skin lesions or hypersensitivity to topical formulations Current use of topical analgesics on the target knee Cognitive impairment preventing adherence to the protocol Participation in another clinical trial within the last 30 days

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oa knee Older adults (60 - 85 years old)

Contacts and locations

Locations

  • Hospital Regional de Alta Especialidad "Centenario de la Revolución Mexicana" - ISSSTE, Servicio de Alimentación y Nutrición Clínica

    Xochitepec, Morelos, 62790, Mexico

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