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Extra nerve block eases pain after knee surgery, study finds

NCT ID NCT07478783

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a genicular nerve block to a standard femoral nerve block improves pain control after total knee replacement. Eighty adults having knee surgery were split into two groups: one got the standard block, the other got both blocks. Researchers measured pain scores and how much extra pain medicine patients needed in the first 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine
What this could lead to
If this works, it could offer a better way to manage pain after knee replacement, helping patients move sooner and use less pain medication.
What could go wrong
This is a small, completed trial with 80 patients. The results may not apply to everyone, and nerve blocks carry risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Nov 2021

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients aged ≥18 years Scheduled for elective total knee replacement surgery American Society of Anesthesiologists (ASA) physical status I-III Planned to receive femoral nerve block with or without genicular nerve block Ability to provide written informed consent Exclusion Criteria: Refusal to participate Contraindication to regional anesthesia Coagulopathy or ongoing anticoagulant therapy incompatible with nerve block Infection at the injection site Known allergy to local anesthetics Severe hepatic or renal insufficiency Cognitive impairment preventing pain assessment Chronic opioid use or opioid dependency

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Total knee anthroplasty

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    Etimesgut, Ankara, 06790, Turkey (Türkiye)

  • Ankara Bilkent City Hospital

    Ankara, Turkey, Turkey (Türkiye)

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