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Knee implant showdown: which one works better?

NCT ID NCT01064063

Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for several years to measure knee scores and success rates.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vanguard Cruciate Retaining knee implant and AGC total condylar knee implant
What this could lead to
If one implant proves better, it could lead to improved knee replacement outcomes for patients with arthritis.
What could go wrong
This is a completed trial with 150 participants, so results are limited to this group and may not apply to all patients. Both implants are already in use, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

150 people

The number who actually took part.

Started

Feb 2011

Finished

May 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pre-op knee score of \<70 * Scheduled to undergo primary total knee replacement with any of the following indication: 1. pain and disabled knee joint resulting from Osteoarthritis, Rheumatoid Arthritis, or Traumatic arthritis. 2. One or more compartments involved. * Need to obtain pain relief and improve function * Ability and willingness to follow instructions, including control of weight and activity level, and to return for follow-up evaluations * A good nutritional state of the patient * Full skeletal maturity of the patient, patients who are at least 18 years of age. * Patients of either sex * Consent form read, understood, and signed by patient Exclusion Criteria: * Pre-op knee score greater than or equal to 70 * Infection * Osteomyelitis * Previous partial or total prosthetic knee replacement on the operative side * Skeletal immaturity of the patient, patients who are less than 18 years of age. * Sepsis * Uncooperative patient or patient with neurological disorders who are incapable of following directions * Osteomalacia * Distant foci of infections * Rapid joint destruction, marked bone loss, or bone resorption apparent on roentgenogram * Vascular insufficiency, muscular atrophy, or neuromuscular disease in affected limb * Incomplete or deficient soft tissue surrounding the knee

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Conditions

The condition(s) this trial relates to.

osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis Rheumatoid arthritis Traumatic arthritis

Contacts and locations

Locations

  • East Sussex Hospital NHS Trust

    Saint Leonards-on-Sea, East Sussex, TN37 7RD, United Kingdom

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