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Knee replacement pain: can a simple injection match a nerve block?

NCT ID NCT07744503

Symptom relief Sponsor: Christopher Male Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This trial asks whether a numbing injection directly into the knee works as well as a continuous nerve block for controlling pain after knee replacement surgery. Adults aged 18 to 90 with knee arthritis scheduled for a first knee replacement are randomly assigned to receive either the injection or the nerve block. Pain levels, knee movement, and satisfaction are measured over several days to see if the simpler injection method is a viable alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Local infiltration analgesia (LIA) with local anesthetics versus continuous femoral and sciatic nerve block with ropivacaine
What this could lead to
If LIA works as well as a nerve block, it could offer a simpler, less invasive pain relief option after knee replacement surgery.
What could go wrong
This is a small, single-center trial, and results may not apply to all patients. Also, LIA might not provide the same level of pain control as a nerve block for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

78 people

The number who actually took part.

Started

Jun 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 90 years * Primary or secondary knee osteoarthritis (gonarthrosis) * Scheduled for elective primary total knee arthroplasty (cruciate-retaining implant) * Ambulatory prior to surgery (able to walk unassisted) * American Society of Anesthesiologists (ASA) physical status I-III * Able to provide written informed consent Exclusion Criteria: * Post-traumatic knee arthropathy (trauma-related indication for surgery) * Wheelchair use / inability to ambulate preoperatively * ASA physical status IV or higher * Lack of capacity to provide informed consent (e.g., legal guardianship/procurator required) * Planned unicompartmental (hemi-) knee arthroplasty or revision surgery * Known allergy or contraindication to the study medications (ropivacaine, ketorolac, or epinephrine)

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthroplasty, replacement, knee Osteoarthritis, knee Pain, postoperative

Contacts and locations

Locations

  • Elisabethinen Krankenhaus Klagenfurt

    Klagenfurt, Carinthia, 9020, Austria

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