Could a simple mineral injection beat standard care for jaw pain?
NCT ID NCT07745660
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injection) and a saline placebo in adults with jaw joint pain or disc displacement. The main focus is on how much chewing pain changes after four weeks, with additional measures of jaw opening, daily function, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- magnesium sulfate
- What this could lead to
- If magnesium sulfate proves effective, it could offer a new, affordable option for easing jaw pain and improving function after a common TMJ procedure.
- What could go wrong
- This is a small pilot study, so results may not be definitive. The effect of magnesium sulfate on TMJ pain is not yet established, and individual responses may vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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33 people
The number who actually took part.
- Started
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Feb 2026
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:Age between 18 and 65 years. Diagnosis of temporomandibular joint arthralgia and/or painful disc displacement with reduction or disc displacement without reduction with limited opening according to DC/TMD Axis I criteria. Predominantly unilateral temporomandibular joint symptoms lasting for at least 6 weeks. Resting or chewing-related pain intensity of at least 4 on a 0-10 Visual Analog Scale. Clinical indication for temporomandibular joint arthrocentesis. Ability to understand and complete the Turkish-language questionnaires. Provision of written informed consent. - Exclusion Criteria:Active local or systemic infection. Advanced degenerative temporomandibular joint disease, defined by clinical crepitus together with advanced imaging findings or Wilkes stage IV-V disease. Intra-articular injection within the previous 3 months. Temporomandibular joint arthroscopy or open joint surgery within the previous 6 months. Pregnancy or breastfeeding. Coagulopathy or use of anticoagulant medication that could not be discontinued. Known hypersensitivity to any of the study agents. Severe psychiatric disorder or any condition preventing completion of the study questionnaires. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Van Yuzuncu Yil University Faculty of Dentistry
İpekyolu, Van, 65100, Turkey (Türkiye)
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