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Jaw pain relief? new injection mix shows promise in small trial

NCT ID NCT07373730

Symptom relief Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested whether injecting a mix of platelet-rich fibrin and hyaluronic acid into the jaw joint could help people with TMJ disc problems. Thirty adults with jaw pain, clicking, and limited movement received the treatment or a standard injection. Researchers measured changes in mouth opening, jaw movement, pain, and clicking.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (I-PRF) mixed with hyaluronic acid
What this could lead to
If it works, this could offer a simple injection-based option to reduce jaw pain and improve movement for people with TMJ disorders.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The treatment is not a cure and only aims to ease symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Aug 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. patients aged from 18 to 40 years old. 2. patients diagnosed with internal derangement of TMJ, suffering from limited mandibular movements, joint pain and clicking. 3. Patients who are free from any systemic disease (ASA I). Exclusion Criteria: 1. Patients who have myofascial pain dysfunction syndrome only. 2. Patients who have previous surgery in TMJ. 3. Patients who have previous arthrocentesis within 1 year. 4. Patients with prosthetic joint replacement. 5. Patients allergic to any components of the injecting solution. 6. Patients who received previous trauma to the joint.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular joint disc displacement

Contacts and locations

Locations

  • Faculty of Dentistry, Suez Canal University

    Ismailia, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.