Jaw pain relief? new injection mix shows promise in small trial
NCT ID NCT07373730
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested whether injecting a mix of platelet-rich fibrin and hyaluronic acid into the jaw joint could help people with TMJ disc problems. Thirty adults with jaw pain, clicking, and limited movement received the treatment or a standard injection. Researchers measured changes in mouth opening, jaw movement, pain, and clicking.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
injectable platelet-rich fibrin (I-PRF) mixed with hyaluronic acid
What this could lead to
If it works, this could offer a simple injection-based option to reduce jaw pain and improve movement for people with TMJ disorders.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The treatment is not a cure and only aims to ease symptoms.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of Dentistry, Suez Canal University
Ismailia, Egypt