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New antibiotic flush shows promise for treating joint infections

NCT ID NCT04662632

First seen Apr 25, 2026 · Last updated May 24, 2026 · Updated 6 times

Summary

This study tested a new method to treat serious joint infections after hip or knee replacement. It involved 76 people who needed a two-step surgery to replace an infected joint. The experimental treatment used a special solution of two antibiotics (vancomycin and tobramycin) to wash out the joint over 7 days. The goal was to see if this approach was safe and better at clearing the infection and avoiding further surgeries compared to standard care.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cleveland Clinic

    Weston, Florida, 33331, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Columbia

    New York, New York, 10032, United States

  • Covenant Medical Center

    Saginaw, Michigan, 48602, United States

  • Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • Integris Southwest Medical Center

    Oklahoma City, Oklahoma, 73103, United States

  • New York University

    New York, New York, 10003, United States

  • Ohio State University

    Columbus, Ohio, 43202, United States

  • OrthoCarolina Research Institute, Inc

    Charlotte, North Carolina, 28207, United States

  • Rothman Orthopaedic Institute

    Philadelphia, Pennsylvania, 19107, United States

  • Texas Health Presbyterian

    Plano, Texas, 75093, United States

  • UVA Orthopedics Center

    Charlottesville, Virginia, 22903, United States

  • University of Arizona, Phoenix

    Phoenix, Arizona, 85004, United States

  • University of Florida

    Gainesville, Florida, 32611, United States

  • University of Kentucky

    Lexington, Kentucky, 40506, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

  • VA Medical Center

    Washington D.C., District of Columbia, 20422, United States

Conditions

Explore the condition pages connected to this study.