Jaw pain breakthrough? MRI may predict who benefits from a One-Time injection
NCT ID NCT07750522
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with conservative care will receive the injection and be followed for 6 months. Researchers will track pain, clicking, and mouth opening, and repeat MRI at 6 months to see if imaging changes match clinical outcomes. The goal is to help doctors identify who is most likely to benefit from this minimally invasive treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A single injection into the jaw joint combining hyaluronic acid with platelet-rich plasma (PRP) made from the participant's own blood.
- What this could lead to
- If MRI findings predict who improves, doctors could better select patients for this minimally invasive injection, sparing others from ineffective procedures.
- What could go wrong
- This is a small, early-stage study without a comparison group, so benefits may not be confirmed. The injection itself carries risks like pain, swelling, or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\. Patients age between (18 -45). 2. Early/intermediate stage according to (Wilkes classification). 3. Patients have painful joint, clicking sound, with or without limited mouth opening. 4\. Patients unresponsive to conservative treatment. 5. Patient's ability and desire to complete the treatment protocol and follow up visits. 6\. Patients with internal derangement with reduction confirmed by MRI imaging Exclusion Criteria: \- 1. Patient with an inflammatory or connective tissue disease 2. Patient with previous invasive TMJ surgical procedure. 3. neurologic disorders 4. History of injection of any substance into the target TMJ during previous 6 months. 5\. Patient with history of bony or fibrous adhesion. 6. Internal derangement without reduction. 7. Patient with psychological problem
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Dentistry, Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.