Can a simple steroid shot ease frozen shoulder pain?
NCT ID NCT06626568
First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times
Summary
This study tested whether steroid injections given every two weeks can improve shoulder function and reduce pain in people with frozen shoulder. Forty adults received either an ultrasound-guided injection into the shoulder or a shot in the buttock, plus a placebo. The goal was to see if the longer interval between doses works and to plan a larger future trial.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- betamethasone (a steroid)
- What this could lead to
- If successful, this could show that spacing out steroid injections every two weeks is just as effective for frozen shoulder, making treatment more convenient.
- What could go wrong
- This is a small pilot study with only 40 participants, so results may not apply to everyone. The study is mainly designed to plan a larger trial, not to prove effectiveness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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40 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. History of ≤9 months, clinically diagnosed with primary frozen shoulder (including frozen shoulder associated with diabetes). 2. Aged between 18 and 75 years old 3. Pain NRS score ≥4 4. Measured passive range of motion of the affected shoulder in at least two of the three directions (forward flexion, external rotation with arm at the side, and internal rotation with arm at the side) is reduced by 25% or more compared to the contralateral normal shoulder. 5. Exclusion of osteoarthritis, dislocation, and other shoulder abnormalities through X-ray and MRI of the affected shoulder. Exclusion Criteria: 1. Secondary frozen shoulder caused by thyroid disease, cardiovascular disease, cancer, stroke, radiotherapy, neurosurgery, or breast surgery (excluding diabetes); secondary frozen shoulder caused by major shoulder trauma requiring medical care (e.g., fractures, dislocations, rotator cuff tears). 2. Full-thickness rotator cuff tear in the affected shoulder confirmed by MRI (excluding rotator cuff tendinopathy and partial-thickness rotator cuff tear in patients with frozen shoulder without a history of major shoulder trauma). 3. Patients unable to undergo MRI due to financial reasons, claustrophobia, pacemaker, or other metallic implants in the body. 4. Local infection in the affected shoulder or other contraindications to shoulder injections. 5. Patients with contraindications to steroid therapy (e.g., poorly controlled blood sugar in diabetes). 6. Patients with frozen shoulder who have already undergone shoulder injections, manipulation under anesthesia, arthroscopic capsular release, or open surgery for capsular release. 7. Received any form of steroid treatment within the past 3 months. 8. History of glucocorticoid use for more than 3 months. 9. Bilateral frozen shoulder or a history of frozen shoulder in the contralateral shoulder. 10. Pregnant or breastfeeding women. 11. Patients lacking the cognitive ability to comply with the study protocol. 12. Patients not residing in the area where the study is being conducted. 13. Patients with compensation claims or legal disputes related to workplace injury or car accidents.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, 315020, China
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Guangde County People's Hospital
Xuancheng, Anhui, 242299, China
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Huzhou Central Hospital
Huzhou, Zhejiang, 313000, China
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Pujiang People's Hospital
Jinhua, Zhejiang, 322200, China
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Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
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Shengzhou People's Hospital
Shanhu, Zhejiang, 312400, China
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The First People's Hospital of Linping District, Hangzhou
Hangzhou, Zhejiang, 311199, China
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Xiangshan County Traditional Chinese Medicine Hospital Healthcare Group
Ningbo, Zhejiang, 315799, China
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Yangpu District Central Hospital of Shanghai
Shanghai, Shanghai Municipality, 200082, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Muscle chain therapy put to the test for frozen shoulder
- Can radiofrequency heat thaw a frozen shoulder?
- Can retraining the brain unlock a frozen shoulder?
- Can simple exercises or TENS ease diabetic shoulder pain?
- Hormone therapy may thaw frozen shoulders faster — a trial puts it to the test
- Could a simple local anesthetic replace general anesthesia for frozen shoulder treatment?