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Can a simple steroid shot ease frozen shoulder pain?

NCT ID NCT06626568

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tested whether steroid injections given every two weeks can improve shoulder function and reduce pain in people with frozen shoulder. Forty adults received either an ultrasound-guided injection into the shoulder or a shot in the buttock, plus a placebo. The goal was to see if the longer interval between doses works and to plan a larger future trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
betamethasone (a steroid)
What this could lead to
If successful, this could show that spacing out steroid injections every two weeks is just as effective for frozen shoulder, making treatment more convenient.
What could go wrong
This is a small pilot study with only 40 participants, so results may not apply to everyone. The study is mainly designed to plan a larger trial, not to prove effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

40 people

The number who actually took part.

Started

Oct 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. History of ≤9 months, clinically diagnosed with primary frozen shoulder (including frozen shoulder associated with diabetes). 2. Aged between 18 and 75 years old 3. Pain NRS score ≥4 4. Measured passive range of motion of the affected shoulder in at least two of the three directions (forward flexion, external rotation with arm at the side, and internal rotation with arm at the side) is reduced by 25% or more compared to the contralateral normal shoulder. 5. Exclusion of osteoarthritis, dislocation, and other shoulder abnormalities through X-ray and MRI of the affected shoulder. Exclusion Criteria: 1. Secondary frozen shoulder caused by thyroid disease, cardiovascular disease, cancer, stroke, radiotherapy, neurosurgery, or breast surgery (excluding diabetes); secondary frozen shoulder caused by major shoulder trauma requiring medical care (e.g., fractures, dislocations, rotator cuff tears). 2. Full-thickness rotator cuff tear in the affected shoulder confirmed by MRI (excluding rotator cuff tendinopathy and partial-thickness rotator cuff tear in patients with frozen shoulder without a history of major shoulder trauma). 3. Patients unable to undergo MRI due to financial reasons, claustrophobia, pacemaker, or other metallic implants in the body. 4. Local infection in the affected shoulder or other contraindications to shoulder injections. 5. Patients with contraindications to steroid therapy (e.g., poorly controlled blood sugar in diabetes). 6. Patients with frozen shoulder who have already undergone shoulder injections, manipulation under anesthesia, arthroscopic capsular release, or open surgery for capsular release. 7. Received any form of steroid treatment within the past 3 months. 8. History of glucocorticoid use for more than 3 months. 9. Bilateral frozen shoulder or a history of frozen shoulder in the contralateral shoulder. 10. Pregnant or breastfeeding women. 11. Patients lacking the cognitive ability to comply with the study protocol. 12. Patients not residing in the area where the study is being conducted. 13. Patients with compensation claims or legal disputes related to workplace injury or car accidents.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • First Affiliated Hospital of Ningbo University

    Ningbo, Zhejiang, 315020, China

  • Guangde County People's Hospital

    Xuancheng, Anhui, 242299, China

  • Huzhou Central Hospital

    Huzhou, Zhejiang, 313000, China

  • Pujiang People's Hospital

    Jinhua, Zhejiang, 322200, China

  • Second Affiliated Hospital, School of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310009, China

  • Shengzhou People's Hospital

    Shanhu, Zhejiang, 312400, China

  • The First People's Hospital of Linping District, Hangzhou

    Hangzhou, Zhejiang, 311199, China

  • Xiangshan County Traditional Chinese Medicine Hospital Healthcare Group

    Ningbo, Zhejiang, 315799, China

  • Yangpu District Central Hospital of Shanghai

    Shanghai, Shanghai Municipality, 200082, China

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Other studies related to the condition(s) this trial covers.