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Which exercise retrains the knee best? a Head-to-Head test

NCT ID NCT07766083

Disease control Sponsor: University of Faisalabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study compares two supervised exercise programs—motor control retraining and close kinetic chain exercises—to see which better reduces pain, improves knee function, and strengthens a key thigh muscle in people with patellofemoral pain syndrome (pain around the kneecap). Fifty adults aged 18 to 40 with this condition will be randomly assigned to one of the two programs, attending 45-minute sessions three times a week for six weeks. Researchers will measure pain, knee function, muscle strength, and knee alignment to determine which approach offers greater benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Motor control retraining exercises and close kinetic chain exercises
What this could lead to
If one exercise approach proves more effective, it could give physiotherapists a clearer, evidence-based choice for treating patellofemoral pain syndrome.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. Exercise programs depend on adherence, and outcomes may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Apr 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 40 years old. * Both genders male \& female. * Clinically diagnosed PFPS patients. * Anterior knee pain \>3 on VAS for \> 2 weeks. * Retropatellar pain during at least 3 of the following activities, i.e., jumping, kneeling, ascending \& descending stairs, squatting, running, prolonged sitting. * BMI range from 18.5 - 24.9 kg/m² . * Not receiving previously knee physiotherapy. * Insidious onset of symptoms unrelated to trauma. * Patellar compression test positive. * Clarke's test positive. * Snapps questionnaire score 6 or greater. Exclusion Criteria: * Age \> 40 years old. * Knee joint effusion . * BMI \< 18 \& \> 29 kg/m². * Any other significant injury that affect lower limb . * Any history of previous knee surgery. * Having referred pain from the lumbar, hip, ankle, feet, and SIJ . * Any history of knee pathology, including OA, meniscus injury, ligament injury, tendon injury, cartilage injury, iliotibial band involvement, intra articular pathology, patellar instability, osgood-schlatter syndrome, pes anserine pain, RA of knee . * Any history of neurological condition . * Pregnant females . * Any condition affected muscle strength, i.e., gout, DM, RA . * History of head injury, vestibular disorder within 6 months. * Any history of patellar dislocation or subluxation . * Signs and symptoms \< 1 month. * Use of corticosteroids, anti-inflammatory \& intra-articular injections. * Heart condition that precluded performing exercises.

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Conditions

The condition(s) this trial relates to.

patellofemoral pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Close kinetic chain exercises Motor control retraining Patellofemoral pain syndrome

Contacts and locations

Locations

  • Department of Rehabilitation Sciences, The University of Faisalabad

    Faisalabad, Punjab Province, 38000, Pakistan

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