Gum treatment may ease arthritis symptoms, study finds

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA: * rheumatoid arthritis diagnosed for at least one year * DAS28 score between 3.2 and 5.1 * no change to medication, dosage or formulation in RA treatment during the 3 months preceding the screening visit * subject available for all study visits over three months in the Dental Care Departments (V1 to V4) * subjects with at least six natural teeth with root * subject with periodontitis, defined by the presence of one site with periodontal probing depth ≥ 4 mm and clinical attachment level ≥ 3 mm on at least 4 teeth. * subject has given his informed consent: 1 week cooling-off period EXCLUSION CRITERIA: * subject will not qualify for enrolment if he presents at least one of the following: acute oral infection, acute oral pain (including pulpitis), suspicious oral mucosal lesion, severe oral inflammation unrelated to periodontal conditions, or need for immediate tooth extractions * have a planned hospitalization within 4 months after the screening visit * subject suffering from one or more known infectious diseases (HIV, hepatitis, infectious mononucleosis), * subject suffering from known clinically significant renal disease (creatinine clearance \<60 ml/min), or liver disease, * unbalanced diabetes * have a known risk of endocarditis, * have a permanent pacemaker, * subject taking antithrombotic treatment, * subject having severe difficulties in understanding written and spoken French * for females: are pregnant or intending to become pregnant, or lactating * subject suffering from a chronic disorder that requires chronic or intermittent use of antibiotics, * subject having known hypersensitivity to chlorhexidine gluconate * are participating in another intervention study * have known contraindications to both amoxicillin and clindamycin * have known contraindications to dental local anesthetic.