Knee replacement pain study aims to cut chronic pain risk
NCT ID NCT03998813
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves knee function. About 287 adults scheduled for knee replacement will take part.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ropivacaine
- What this could lead to
- If successful, this could point to a better way to manage pain after knee replacement, reducing the chance of long-term chronic pain and improving recovery.
- What could go wrong
- This is a single-center study, and results may not apply to all patients. The two techniques may show little difference, or one may have unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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287 people
The number who actually took part.
- Started
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Sep 2020
- Finished
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Apr 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patient; * Placement of unilateral tricompartmental knee prosthesis for gonarthrosis; * ASA score between I and III ; * Nonseptic scheduled surgery; * Knee replacement scheduled on one of the first 3 days of the week (Monday to Wednesday included) in order to benefit from a homogeneous postoperative physical therapy; * Able to understand the protocol; * Having agreed to participate in the study and having given express oral consent; * Affiliated with a social security system; * Possibility of being followed as part of the protocol. Exclusion Criteria: * Age \>= 86 years old; * BMI \> 35 ; * Revision of knee replacement; * Symptomatic contralateral osteoarthritis; * Anterior of surgery on the operated knee (excluding arthroscopy and meniscectomy); * Vascular surgery on the femoral vessels on the operated side; * Concept of diffuse polyalgia syndrome (fibromyalgia); * Documented neuropathy of the lower limb; * Localized infection at the catheter puncture site (femoral triangle); * Known allergy to Ropivacaine; * Renal insufficiency (Clearance - CKD-EPI formula - creatinine \<30 ml/min) and/or severe hepatic insufficiency (prothrombin blood level \<50%) ; * Inflammatory rheumatic disease (rheumatoid arthritis, ankylosing spondylitis...) ; * Patients on immunosuppressive or systemically administered corticosteroid therapy; * Daily use of level II or III analgesics for more than one month pre-operatively; * Known intolerance to tier III analgesics; * Allergy or contraindications to standard treatments administered per and postoperatively (paracetamol, NSAIDs); * Patient undergoing knee surgery in the year prior to inclusion and participating in the study; * Patients who do not cooperate or do not understand French, difficulties in understanding and evaluating the pain score, preoperative cognitive dysfunction making the interview unreliable; * Patient under guardianship, curators, deprivation of liberty; * Patient already engaged in another interventional clinical study (category 1); * Pregnant or breastfeeding women, or women in a position to procreate who refuse an effective means of contraception; * Refusal to participate; * Inability to understand the protocol and its requirements, and/or to give express oral consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, 85925, France
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Centre Hospitalier de Béthune Beuvry
Béthune, France
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Clinique Victor PAUCHET
Amiens, France
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Hôpital Privé Sévigné
Rennes, France
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Hôpital des Diaconesses Croix Saint Simon
Paris, France
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