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Daily painkillers may shield spines in arthritis patients on biologics

NCT ID NCT02469753

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use reduces the progression of bone growth in the spine, which can cause stiffness and fusion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NSAIDs (non-steroidal anti-inflammatory drugs) taken daily
What this could lead to
If successful, this could show that taking NSAIDs every day helps prevent spine damage in people with ankylosing spondylitis who are already on anti-TNF therapy.
What could go wrong
This is a completed Phase 3 trial with 188 participants, but results are not yet widely known. NSAIDs have side effects like stomach issues, and the benefit may be small or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

188 people

The number who actually took part.

Started

Oct 2015

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged over 18 years old * Patients who fulfil 1984 modified New York criteria for ankylosing spondylitis: * SA patients with indications for anti-TNF treatment initiation according to the French society of Rheumatology guidelines. * Being affiliated to a health insurance system * Having signed an informed consent form (later than the day of inclusion and before any examination required by the research) Exclusion Criteria: * Patients who present another chronic systemic inflammatory disorder, different from ankylosing spondylitis. * Patients who present contraindications to treatment with NSAIDs. * Patient with daily corticosteroid treatment at a dosage ≥ 10 mg/day * Pregnant or breastfeeding women * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing to undergo MRI * Women that refuse to an effective contraception method for all the study duration

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankylosing spondylitis

Contacts and locations

Locations

  • Service de Rhumatologie - CHU de Bordeaux

    Bordeaux, France

  • Service de rhumatologie - AP-HP - Hôpital Lariboisière

    Paris, France

  • Service de rhumatologie - CHU d'Amiens

    Amiens, France

  • Service de rhumatologie - CHU de Besançon

    Besançon, France

  • Service de rhumatologie - CHU de Brest

    Brest, France

  • Service de rhumatologie - CHU de Nice

    Nice, France

  • Service de rhumatologie - CHU de Tours

    Tours, France

  • service de Rhumatologie - CH Princesse Grace

    Monaco, Monaco

  • service de rhumatologie - AP-HP - Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • service de rhumatologie - AP-HP - Hôpital Henri Mondor

    Paris, France

  • service de rhumatologie - AP-HP- Hôpital La Pitié Salpétrière

    Paris, France

  • service de rhumatologie - CH Le Mans

    Le Mans, France

  • service de rhumatologie - CH de Cahors

    Cahors, France

  • service de rhumatologie - CHR d'Orléans

    Orléans, France

  • service de rhumatologie - CHU de Limoges

    Limoges, France

  • service de rhumatologie - CHU de Montpellier

    Montpellier, France

  • service de rhumatologie - CHU de Nancy

    Nancy, France

  • service de rhumatologie - CHU de Rouen

    Rouen, France

  • service de rhumatologie - CHU de Saint-Etienne

    Saint-Etienne, France

  • service de rhumatologie - CHU de Strasbourg

    Strasbourg, France

  • service de rhumatologie - CHU de Toulouse

    Toulouse, France

  • service de rhumatologuie - CH de Pau

    Pau, France

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Other studies related to the condition(s) this trial covers.