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Knee replacement patients may need less morphine with gabapentin

NCT ID NCT01307202

Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-related side effects like nausea and dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

101 people

The number who actually took part.

Started

Oct 2007

Finished

Feb 2011

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * participants aged 19-90 * elective single joint, primary total knee arthroplasty * use of PCA with morphine for postoperative pain control has been discussed and agreed upon between patient and anesthetist Exclusion Criteria: * bilateral total knee arthroplasty * revision knee arthroplasty * underlying disease of epilepsy, seizure, or chronic pain syndrome * active gastrointestinal bleeding within the last 6 months * history of non-steroidal anti-inflammatory drug (NSAID) induced asthma * known or suspected history of drug or alcohol abuse * participant currently takes gabapentin or pregabalin for any reason * participant currently takes pain medication that is more potency than codeine or oxycodone (morphine, hydromorphone, meperidine, methadone, fentanyl, including any long acting narcotics) * known allergy to study medications: gabapentin, morphine, NSAID, acetaminophen * unable to tolerate morphine * liver impairments * kidney impairment or calculated creatinine clearance by Cockcroft-Gault formula is \<=60ml/min * pregnancy or breast-feeding * participant currently receives associated worker's compensation benefits (WSIB) * participant unable or unwilling to give written or informed consent * unable to use PCA

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative pain Total knee replacement

Contacts and locations

Locations

  • Hamilton Health Sciences

    Hamilton, Ontario, L8N 3Z5, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.