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Scientists test designer immune molecules in autoimmune diseases

NCT ID NCT05544448

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested these modified proteins in the lab. The goal was to see if the proteins could activate the right cells without overstimulating the immune system, potentially leading to better treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

67 people

The number who actually took part.

Started

Oct 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion criteria common to all patients in different departments: * Age18 years * Affiliated to social security or entitled to * Patient who has been informed of the study and has signed a free and informed consent Inclusion criteria specific by department: Inclusion criteria for Clinical Hematology Department: * Patient with GVHD following allogeneic hematopoietic stem cell transplantation (HSC) * Or with acquired bone marrow suppression * Lymphocytosis \> 0.5 G/L Inclusion criteria for Nephrology and Transplantation department: \- Patient with systemic lupus erythematosus (ACR classification criteria) Inclusion criteria for Neurology department: \- Patient with multiple sclerosis (criteria of Mc Donald 2017) Inclusion criteria for Rheumatology Department: \- Patient with rheumatoid arthritis (ACR classification criteria) Inclusion criteria for Internal Medicine-Endocrinology Department: \- Patient with Basedow disease, Hashimoto's thyroiditis Inclusion criteria for Dermatology Department: \- Patient with vitiligo or alopecia areata or atopic dermatitis Exclusion Criteria: Non-inclusion criteria common to all patients: * Patient under guardianship, curatorship or judicial protection * Pregnant, parturient or breastfeeding woman * Patient deprived of liberty * Patient hospitalized without consent * Patient admitted to a health or social institution for purposes other than research * Minor patient * Adult patient unable to express consent * Refusal to participate * Patient on AME Non-inclusion criteria specific by department: Non-inclusion criteria for Clinical Hematology Department: * Ongoing treatment with high doses (\>1 mg/kg/d) of systemic corticosteroid therapy * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Nephrology and Transplantation Department: * Ongoing treatment with doses \>10 mg/d Prednisone * Ongoing treatment with Cellcept, Endoxan, Imurel, Belimumab, Anti-CD20, Methotrexate * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Neurology Department: * Treatment with systemic corticosteroid therapy, Fingolimod or Teriflunomide * Ongoing treatment with JAK inhibitors * Lymphocytosis \< 0.5 G/L Non-inclusion criteria for Rheumatology Department: * Ongoing treatment with doses \>15 mg/d Prednisone * Treatment with Rituximab or Tocilizumab * Ongoing treatment with JAK inhibitors * Lymphocytosis \< 0.5 G/L Non-inclusion criteria for Internal Medicine - Endocrinology Department: * Ongoing immunosuppressive therapy * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Dermatology Department: * Ongoing treatment with Methotrexate * Ongoing treatment with JAK inhibitors * Ongoing treatment with doses \>10 mg/d prednisone

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hôpital Henri Mondor, 1 rue Gustave Eiffel,

    Créteil, Île-de-France Region, 94000, France

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Other studies related to the condition(s) this trial covers.