Scientists test designer immune molecules in autoimmune diseases
NCT ID NCT05544448
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested these modified proteins in the lab. The goal was to see if the proteins could activate the right cells without overstimulating the immune system, potentially leading to better treatments in the future.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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67 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Jun 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Inclusion criteria common to all patients in different departments: * Age18 years * Affiliated to social security or entitled to * Patient who has been informed of the study and has signed a free and informed consent Inclusion criteria specific by department: Inclusion criteria for Clinical Hematology Department: * Patient with GVHD following allogeneic hematopoietic stem cell transplantation (HSC) * Or with acquired bone marrow suppression * Lymphocytosis \> 0.5 G/L Inclusion criteria for Nephrology and Transplantation department: \- Patient with systemic lupus erythematosus (ACR classification criteria) Inclusion criteria for Neurology department: \- Patient with multiple sclerosis (criteria of Mc Donald 2017) Inclusion criteria for Rheumatology Department: \- Patient with rheumatoid arthritis (ACR classification criteria) Inclusion criteria for Internal Medicine-Endocrinology Department: \- Patient with Basedow disease, Hashimoto's thyroiditis Inclusion criteria for Dermatology Department: \- Patient with vitiligo or alopecia areata or atopic dermatitis Exclusion Criteria: Non-inclusion criteria common to all patients: * Patient under guardianship, curatorship or judicial protection * Pregnant, parturient or breastfeeding woman * Patient deprived of liberty * Patient hospitalized without consent * Patient admitted to a health or social institution for purposes other than research * Minor patient * Adult patient unable to express consent * Refusal to participate * Patient on AME Non-inclusion criteria specific by department: Non-inclusion criteria for Clinical Hematology Department: * Ongoing treatment with high doses (\>1 mg/kg/d) of systemic corticosteroid therapy * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Nephrology and Transplantation Department: * Ongoing treatment with doses \>10 mg/d Prednisone * Ongoing treatment with Cellcept, Endoxan, Imurel, Belimumab, Anti-CD20, Methotrexate * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Neurology Department: * Treatment with systemic corticosteroid therapy, Fingolimod or Teriflunomide * Ongoing treatment with JAK inhibitors * Lymphocytosis \< 0.5 G/L Non-inclusion criteria for Rheumatology Department: * Ongoing treatment with doses \>15 mg/d Prednisone * Treatment with Rituximab or Tocilizumab * Ongoing treatment with JAK inhibitors * Lymphocytosis \< 0.5 G/L Non-inclusion criteria for Internal Medicine - Endocrinology Department: * Ongoing immunosuppressive therapy * Ongoing treatment with JAK inhibitors Non-inclusion criteria for Dermatology Department: * Ongoing treatment with Methotrexate * Ongoing treatment with JAK inhibitors * Ongoing treatment with doses \>10 mg/d prednisone
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Henri Mondor, 1 rue Gustave Eiffel,
Créteil, Île-de-France Region, 94000, France
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