AUTOIMMUNE DISEASES

This study provides access to unlicensed, frozen cord blood units for transplant in children and adults with blood cancers and other serious blood disorders. Researchers aim to track how well patients' immune systems recover after transplant and monitor survival rates and complic…

This early-phase study is testing a therapy called CD19 CAR T-cells in people with severe autoimmune diseases that have not improved with standard treatments. The therapy involves collecting a patient's own immune cells, modifying them to target a specific marker (CD19), and infu…

This study compares two different drug combinations to find which works better at controlling IgG4-related disease and preventing it from flaring up again. Researchers will follow 60 patients with this autoimmune condition affecting superficial organs for 12 months. One group rec…

This early-stage study is testing the safety of an experimental cell therapy called GT719 injection in people with severe autoimmune diseases like lupus, scleroderma, and inflammatory muscle diseases that haven't improved with standard medications. The trial will enroll 10 partic…

This early-stage study is testing a new cell therapy for children with severe autoimmune diseases that haven't responded to standard treatments. Researchers are modifying a patient's own natural killer (NK) immune cells to target and remove harmful B cells that drive the disease.…

This early-stage study is testing a new type of cell therapy called anti-CD19/BCMA universal CAR-T cells in people with severe autoimmune diseases that have not improved with standard treatments. The main goals are to check if the treatment is safe and to see if it can help contr…

This early-stage study is testing whether a personalized cell therapy, similar to those used for some blood cancers, can help people with severe autoimmune diseases that haven't responded to standard treatments. Doctors will collect a patient's own immune cells, modify them to ta…

This early-stage study is testing the safety and initial effectiveness of an experimental drug called STR-P004 in adults with autoimmune diseases that have returned or haven't responded to standard treatments. The trial will enroll 39 participants with conditions like lupus and i…

This early-stage study is testing the safety and initial effects of a new type of cell therapy for people with severe autoimmune diseases that haven't responded well to standard treatments. The therapy, called 'universal' CAR-T, uses donated immune cells engineered to target and …

This early-stage study is testing a new injection called AFN50 for people with autoimmune diseases, focusing on lupus that has returned or hasn't responded to standard treatments. Researchers want to see if AFN50 is safe and if it can help control lupus symptoms by measuring dise…

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This is a very early study testing a new type of cell therapy for children with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target the disea…

This study aims to preserve fertility for girls and women under 40 who face cancer treatments or other conditions that could cause permanent infertility. Participants have one ovary surgically removed and frozen for potential future use when they wish to have children. The resear…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This is an early-stage safety study testing a new type of treatment called anito-cel for adults with generalized myasthenia gravis, a chronic autoimmune disease that causes severe muscle weakness. The therapy involves collecting a patient's own immune cells, genetically modifying…

This study is testing a personalized approach for people with severe, hard-to-classify inflammatory diseases that affect multiple organs and have not responded to standard treatments. Researchers will analyze each patient's unique molecular pathways to select a targeted therapy f…

This study is testing whether an online training and peer support platform called 'Support' helps adults with type 1 diabetes manage their daily care. Researchers are comparing two groups: one where doctors recommend the platform as part of regular care, and another where people …

This early-stage study is testing a new mRNA-based therapy called ABO2203 in people with autoimmune diseases that haven't responded well to standard treatments. The main goal is to check if the treatment is safe and tolerable, while also looking for early signs that it might help…

This early-stage study is testing whether a type of cell therapy called CAR-T, which is used to treat some cancers, can help people with serious autoimmune diseases like lupus, scleroderma, and vasculitis. The therapy involves collecting a patient's own immune cells, modifying th…

This study tests whether a special clinic-based program can help more Black and Latinx adults with autoimmune diseases get updated COVID-19 vaccines. Researchers will work with about 1,170 participants who haven't yet received the latest COVID-19 shots. The program provides infor…

This study is testing whether an experimental drug called Diamyd, injected directly into a lymph node, is safe and can prevent or delay the onset of type 1 diabetes. It involves 16 children and teenagers (ages 8-18) who have specific genetic and immune markers putting them at hig…

This study aims to understand if newer automated insulin delivery systems affect eating behaviors and food-related stress in people with type 1 diabetes. Researchers will observe 106 participants in Canada, comparing those using automated systems to those using injections or stan…

This study is collecting and analyzing white blood cells from healthy volunteers and patients with autoimmune diseases or liver transplants. The goal is to gather information that will help researchers design future cell-based treatments. Participants are not receiving any experi…

This study aims to understand why some cancer patients develop serious inflammatory side effects from powerful immunotherapy drugs called immune checkpoint inhibitors. Researchers will collect blood, tissue, and stool samples from 1,000 patients to look for biological markers tha…

This study aims to create better tools for diagnosing and choosing treatments for children with rare autoimmune and inflammatory diseases. Researchers will analyze blood and tissue samples from 500 children to find molecular patterns linked to their conditions. The goal is to pre…

This study aims to collect health information from thousands of people with conditions like Long COVID, ME/CFS, autoimmune diseases, and brain inflammation disorders over 10+ years. Participants will use a secure app to share symptoms, health history, and daily activity data. The…

This registry aims to understand how autoimmune diseases like lupus and rheumatoid arthritis affect pregnancy. Researchers will follow 1,000 pregnant women with these conditions to identify factors linked to poor outcomes. The study collects information from regular doctor visits…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to understand how the immune systems of children with celiac disease react to very small, controlled amounts of gluten. About 45 children, who are already on a strict gluten-free diet, will take either a placebo or one of two small gluten doses for three days. Res…

This study aims to build a collection of blood and tissue samples from children with rare autoimmune and autoinflammatory diseases like lupus. Researchers will analyze these samples to identify genetic changes and immune system problems that cause these conditions. The goal is to…

This study aims to understand why some people continue to experience mental fatigue and 'brain fog' even after their Graves' disease thyroid levels are successfully treated. Researchers will compare blood and spinal fluid from 180 people—including Graves' patients with and withou…

This study aims to understand how rare genetic immune disorders called type 1 interferonopathies progress over time in both children and adults. Researchers will follow 500 European patients to track their symptoms, identify patterns, and find biological markers that could help w…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study aims to understand the long-term health of people who have survived a rare and life-threatening blood clotting disorder called immune thrombotic thrombocytopenic purpura (iTTP). Researchers will look back at the medical records of over 1,200 patients in France to learn…

This study aims to better understand a group of rare, severe genetic diseases that disrupt the immune system and brain, often leading to poor quality of life and high mortality. Researchers will study 1000 participants, including patients, their family members, and healthy contro…

This study aims to understand why autoimmune diseases like lupus and rheumatoid arthritis often appear earlier and are more severe in people of Peruvian ancestry compared to European populations. Researchers will collect blood, urine, and stool samples from 300 participants with …

This study is creating a large registry of patients with immune system diseases who are receiving biologic medications as part of their standard care. Researchers will collect health information and samples from about 800 participants to better understand how these treatments wor…