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Scientists hunt for genetic clues in rare childhood immune disorders

NCT ID NCT06435468

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is not a treatment trial. It aims to collect blood samples from 400 children and their relatives who have rare autoimmune or autoinflammatory diseases (like lupus or juvenile arthritis). Researchers will analyze the samples to find genetic mutations that cause these conditions. The goal is to better understand these rare diseases, which may lead to better diagnosis in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jul 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients * minor or adult patient of any age with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years), or syndromic or familial * relative of a minor or adult patient with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years of age) or syndromic or familial, * weight greater than 5 kg * Patient/parents/guardians who were informed of the study and signed the consent form. * patient affiliated to a social security scheme Healthy volunteer participants * minor or adult participants with no age restrictions * weight over 5 kg * Subject /Parents/guardians who were informed of the study and signed a consent form. * Patient affiliated to a social security scheme Exclusion Criteria: Patients \- Subjects /Parents/guardians, refusing to participate in the study Healthy volunteer participants : * active infection (viral, bacterial, parasitic) * history of neoplasia (\< 5 years) or current neoplasia * participants with a personal or family history of autoimmune disease * immunocompromised participant (immune deficiency or transplant recipient) * Subjects/parents/guardians refusing to participate in the study * Adults under legal protection (guardianship, curatorship)

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoinflammatory syndrome cryopyrin-associated periodic syndrome deficiency of adenosine deaminase 2 familial Mediterranean fever hereditary disease juvenile dermatomyositis juvenile idiopathic arthritis systemic lupus erythematosus TNF receptor 1-associated periodic fever syndrome type 1 interferonopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autoimmune diseases Autoinflammatory disease Genetic disease Systemic lupus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CLCC Henri Becquerel

    NOT_YET_RECRUITING

    Rouen, 76038, France

  • Dr Isabelle MELKI

    RECRUITING

    Paris, 75012, France

  • Dr Vanessa Remy-Piccolo

    RECRUITING

    Villefranche-sur-Saône, France

  • Hôpital Archet 2

    NOT_YET_RECRUITING

    Nice, Nice, 06200, France

  • Hôpital Claude Huriez (CHU de Lille)

    NOT_YET_RECRUITING

    Lille, Lille, 59037, France

  • Hôpital Couple Enfant

    NOT_YET_RECRUITING

    Grenoble, 38043, France

  • Hôpital Jeanne de Flandre (CHU de Lille)

    NOT_YET_RECRUITING

    Lille, Lille, 59000, France

  • Hôpital Kremlin-Bicêtre (AP-HP)

    NOT_YET_RECRUITING

    Paris, Paris, 94270, France

  • Hôpital Necker-Enfants Malades (AP-HP)

    NOT_YET_RECRUITING

    Paris, Paris, 75015, France

  • Hôpital Nord (CHU ST-Etienne)

    NOT_YET_RECRUITING

    Saint-Etienne, Saint Etienne, France

  • Hôpital Robert Debré (AP-HP)

    NOT_YET_RECRUITING

    Paris, Paris, 75935 Paris, France

  • Pr Ariane ZALOSZYC

    RECRUITING

    Strasbourg, France

  • Service de rhumatologie pédiatrique Hôpital Femme-Mère-enfant

    RECRUITING

    Bron, Bron, 69500, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.