AUTOIMMUNE DISEASES

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus that haven't responded to standard therapies. The treatment uses a patient's own immune cells, modified to target and attack faulty immune cells driving the disease…

This early-phase study tests a new mRNA-based drug for people with relapsed autoimmune diseases. The drug targets two proteins (CD19 and BCMA) to clear the B cells and plasma cells that mistakenly attack the body. Up to 27 participants aged 18-70 will receive the treatment to fin…

This early-phase study tests a new mRNA therapy for people with severe autoimmune diseases like lupus or immune anemia. The treatment uses lipid nanoparticles to deliver mRNA that targets and clears certain immune cells (B cells) to reduce disease activity. About 47 participants …

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that have not responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the d…

This study tests whether adding inectolizumab to standard steroid treatment can lower the amount of steroids needed by people newly diagnosed with neuromyelitis optica spectrum disorder (NMOSD). The trial will enroll 25 adults who have not yet been treated and are positive for a …

This study tests a new drug called ATH-063 in people with moderate to severe ulcerative colitis who have not improved with other advanced treatments. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and help the gut heal. About 120 adults will receive…

This study tests a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases. It is for people with severe lupus or other autoimmune conditions that have not responded to standard therapies. The goal is to c…

This early-phase study tests an experimental drug called S-4321 in 24 adults with autoimmune diseases like rheumatoid arthritis, psoriasis, lupus, or eczema. The main goal is to check safety and how the body processes the drug. Researchers will also look at early signs of effecti…

This early study tests a new drug called STR-P004 in 9 adults with immune-mediated kidney diseases. The goal is to see if the drug is safe and how the body processes it. Participants will receive up to 8 infusions over 1-2 months, with possible dose increases to find the best lev…

This study looks at a new way to give recommended vaccines to adults with chronic diseases or weakened immune systems. Doctors will offer vaccines during hospital visits, admissions, or at discharge. The goal is to see how many patients accept and complete their vaccines, and to …

This study will follow 5,000 adults who have immune system problems (like inflammation or autoimmune disease) to see how often they also develop blood disorders, including a rare condition called VEXAS syndrome. Researchers will track new cases over time to better understand the …