AUTOIMMUNE DISEASES

This early-stage study tests a new treatment called RD06-04, which uses a patient's own immune cells modified to target and destroy faulty B cells. It aims to control active autoimmune diseases like lupus, scleroderma, and Sjögren's syndrome. The main goal is to check safety, but…

This study aimed to test whether a combination of four drugs (anti-thymocyte globulin, low-dose interleukin-2, adalimumab, and exenatide) could help people newly diagnosed with type 1 diabetes keep making their own insulin. The trial planned to enroll adults aged 18-35 within 120…

This study was designed to test an experimental drug called HMPL-523 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The goal was to see if the drug is safe and can raise platelet counts. However, th…

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This early-phase study tests a new treatment called Prula-cel for people with certain autoimmune diseases like lupus and scleroderma. Prula-cel uses specially engineered immune cells from a healthy donor to target and attack faulty immune cells that cause disease. The main goals …

This study tests an experimental drug called ifetroban in people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis) or scleroderma-related high blood pressure in the lungs. The goal is to see if the drug is safe and can improve lung function. About 34 adults…

This study tests a treatment called Diamyd® in children aged 8 to 17 who are at high risk for type 1 diabetes. The goal is to see if giving the drug directly into lymph nodes is safe and can prevent or delay the disease. Only 5 children with specific genetic markers are taking pa…

This study looks at whether eating very little gluten (less than 3 grams per day) during the first three years of life can lower the chance of developing celiac disease in children who are genetically at risk. Over 1,100 children with specific genes were enrolled and followed unt…

This study looks at immune cells from people with autoimmune diseases, infectious diseases, and healthy volunteers. Researchers want to understand how these cells differ. The goal is to learn more about how the immune system works in different conditions. Up to 2,500 people will …

This study collects medical information and biological samples from 32 cancer patients starting or restarting immunotherapy. The goal is to better understand why some patients develop immune-related side effects and how to manage them. Researchers hope this knowledge will improve…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will follow 505 adults aged 50 and older to see how many experience mental fogginess (called postoperative cognitive dysfunction) up to 4.5 months after surgery. The goal …

This study is a registry that collects information from people with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Researchers will use surveys and medical records to track health, medications, and pregnancy outcomes. The goal is to learn what factors af…

This study tests whether offering doctors one-on-one educational meetings about biosimilar medications leads them to prescribe more biosimilars instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab will be randomly offered either an in-person o…