AUTOIMMUNE DISEASES

This study looked at how well the seasonal and H1N1 flu vaccines work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were taking steroids or other immune-suppressing medications. The goal was to measure the body's immune response and safety of the v…

This study looked at how safe and effective the GLOBAFFIN® blood filter is for people with autoimmune diseases. It involved 34 adults who were already scheduled to use the filter as part of their routine care. The main goal was to measure how much the filter lowered disease-relat…

This early-stage study tested a new drug, VIS171, in 61 people to see if it is safe. First, healthy volunteers received a single dose. Then, people with autoimmune diseases received multiple doses. The main goal was to check for side effects and how the drug affects immune cells.…

This study tested a new antibody drug (C5 monoclonal antibody) in 16 people with anti-GBM disease, a severe autoimmune condition that often leads to kidney failure. The goal was to see if the drug could improve kidney outcomes and reduce the need for dialysis or transplant. The t…

This study followed 80 adults with pemphigus, a rare autoimmune blistering skin disease, who had previously received rituximab in the Ritux 3 trial. Researchers tracked long-term side effects and how many patients stayed in remission over several years. The goal was to understand…

This study tested a combined bone marrow and kidney transplant from a partially matched family donor for 10 people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one donor, potentially reducing the need for lifelong anti-…

This study tested a non-invasive treatment called transcutaneous electrical acupoint stimulation (TEAS) to see if it can reduce pain and inflammation during menstruation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women with severe period pain …

This study tested whether coaching sessions are practical for young people (ages 16-18) with rheumatic diseases like juvenile arthritis as they move from pediatric to adult rheumatology care. Researchers enrolled 26 participants and measured how many agreed to join, attended sess…

This study looked at whether taking daily vitamin D or fish oil supplements could reduce the risk of autoimmune diseases, lower inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease took part. Researchers measured inflamma…

This study tested whether analyzing a patient's DNA and RNA can help doctors choose the right targeted therapy for hard-to-classify inflammatory diseases affecting multiple organs. Researchers enrolled 32 adults with skin involvement and at least one other affected organ. The goa…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids took part. Res…

This study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and identify what made some patients more at risk. Researchers also looke…

This early-stage study tested the safety and how the body handles a new drug called RLYB116 in 16 healthy adults aged 18 to 55. Participants received multiple doses, and researchers monitored side effects, drug levels, and immune reactions. The goal was to gather safety informati…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…