AUTOIMMUNE DISEASES

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants will use the platform for 12 months, either through their usual clinic or on their own. Researchers will tr…

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis that haven't responded to standard therapies. The treatment uses specially engineered immune cells to target a…

This study gives people with blood cancers, immune disorders, and other serious diseases access to cord blood transplants that are not yet FDA-approved. It includes children and adults of any age. The main goal is to see how well the new blood cells grow after transplant.

This study tests whether an online training and peer support platform, called Support-t, can help teenagers with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either receive usual care or also get access to the platform. …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This study tests two treatment strategies for people with IgG4-related disease (IgG4-RD) that affects superficial organs like glands or lymph nodes. About 60 adults will receive either prednisone plus iguratimod or prednisone plus leflunomide for 12 months. The goal is to see whi…

This early-phase study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't responded to standard therapies. The treatment works by directing the body's immune cells to attack harmful immune cells. The main goal is to check safety and find t…

This early-phase study tests a new injection called AFN50 in 18 adults with autoimmune diseases like lupus. The main goal is to check safety and side effects, while also looking at how the treatment affects immune cells. Participants must have active disease despite standard trea…

This early-phase trial tests an injection called GT719 in 10 people with moderate to severe autoimmune diseases that haven't responded to other treatments. The main goal is to check safety and find the right dose. Researchers will also look for signs that the treatment helps cont…

This early-stage study tests whether specially engineered immune cells (CAR-NK cells) can safely control B cell-related autoimmune diseases in children. The therapy targets two markers on faulty immune cells to reduce disease activity. Up to 12 children with conditions like lupus…

This early-phase study tests whether combining mesenchymal stem cells (MSCs) with CAR-T cells is safe and can help control autoimmune diseases. About 30 adults with established autoimmune conditions will receive the treatment. The goal is to see if symptoms improve or stabilize, …

This study is testing a new treatment called STR-P004 in 39 adults with autoimmune diseases that have come back or not responded to other treatments. The main goal is to see if it is safe and what side effects it may cause. Researchers will also look at how the drug works in the …

This early-stage study tests a new treatment using a patient's own immune cells, modified to target and destroy faulty immune cells causing autoimmune diseases like lupus and scleroderma. The goal is to see if this 'reset' is safe and can control disease activity. About 20 adults…

This early-phase study tests a new treatment called anitocabtagene autoleucel (anito-cel) for people with generalized myasthenia gravis, a condition that causes muscle weakness. Anito-cel is a type of CAR-T cell therapy that targets BCMA, a protein on certain immune cells. The st…

This early study tests a new treatment called CD19 CAR-T cell therapy for people with severe autoimmune diseases like lupus, Sjogren's syndrome, and scleroderma that haven't improved with standard treatments. The therapy uses a patient's own immune cells, modified to target and d…

This study tests a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases. It is for people with conditions like lupus that have not responded to standard therapies. The goal is to see if this approach is…

This early-stage study tests a new treatment using specially engineered immune cells (CAR-NK cells) in 36 children with B-cell-related autoimmune diseases like lupus and IgA nephropathy. The goal is to see if these cells can safely control the disease by targeting and calming the…

This early-stage study is testing a new treatment for people with certain autoimmune diseases like lupus and kidney disease. The treatment uses specially engineered immune cells (CAR T-cells) that target and attack faulty immune cells causing the disease. The main goal is to chec…

This early-phase study tests a personalized cell therapy (CD19 CAR-T) in 15 adults with severe autoimmune diseases like lupus and scleroderma that have not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and destroy faulty B cel…

This early-stage study tests a new treatment called QT-219C, which uses specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells that cause autoimmune diseases like lupus and kidney disease. The treatment involves a one-time infusion after a short chem…

This study tests a new drug called BGB-45035 for the first time in humans. It will check safety and how the body processes the drug in healthy volunteers, then test it in people with autoimmune skin diseases like eczema and prurigo nodularis. The goal is to see if the drug is saf…

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immunotherapy drugs called immune checkpoint inhibitors. The goal is to understand why some patients develop inflammatory side effects (immune-related advers…

This study aims to better understand rare genetic diseases that harm both the immune system and the brain. Researchers will study 1000 people, including patients and their family members, to learn about the symptoms, natural history, and genetic causes of these conditions. The go…

This study aims to find gene changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 adults with conditions like lupus or rheumatoid arthritis, plus their family members and healthy volunteers. The goal is…

This study collects blood samples from 400 children and their relatives to find genetic and immune system abnormalities in rare autoimmune and autoinflammatory diseases like lupus. The goal is to create a biological sample bank for future research. No treatments or interventions …

This study reviews medical records from over 1,200 people who survived immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. Researchers aim to understand long-term risks like heart disease and stroke, and how newer treatments affect survi…

This study looks at whether automated insulin delivery (AID) systems help people with type 1 diabetes have healthier eating behaviors and less stress around food. Researchers will survey 106 youth and adults across Canada about their eating habits and blood sugar control. The goa…

This study looks at how the immune system of children with celiac disease reacts to tiny, controlled amounts of gluten. Kids on a strict gluten-free diet will get either a placebo, a small gluten dose, or a larger one for three days. Researchers will analyze blood, stool, and uri…

This study collects and analyzes white blood cells from healthy volunteers and patients with autoimmune diseases, inflammation, or liver transplant. The goal is to understand these cells better so researchers can design engineered regulatory T cell (Treg) therapies. The study doe…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study is a registry that will enroll up to 1,000 pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will collect information to identify risk factors for poor pregnancy outcomes. The goal…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study is creating a large registry of 800 patients receiving biologic medications for immune diseases like autoimmune conditions and primary immune deficiencies. Researchers will collect medical records, samples, and survey data to better understand how these treatments work…

This study collects tissue and blood samples from 300 people with autoimmune diseases like ulcerative colitis, multiple sclerosis, and Crohn's disease. Researchers will identify which T-cells are active in inflamed tissues and find their targets. The goal is to discover new targe…

This study is creating a tool to help doctors diagnose and choose treatments for autoimmune diseases. Researchers will analyze blood and other samples from 500 children with autoimmune conditions and healthy children to find patterns in genes and proteins. The goal is to better u…

This study tests a new program to help Black and Latinx adults with rheumatic diseases get the updated COVID-19 vaccine. About 1,170 participants will receive a patient-directed behavioral intervention in rheumatology clinics. The goal is to see if this approach increases vaccina…

This study aims to learn more about a group of rare genetic diseases called type 1 interferonopathies, which cause the immune system to be overactive and can affect the brain, joints, and blood. Researchers will follow 500 children and adults with these conditions over time to tr…

This study aims to understand why some people with Graves' disease continue to experience mental fatigue even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid samples from 180 participants—60 with mental fatigue, 60 without, and 60 heal…

This study aims to help preserve fertility in females under 40 who face infertility due to treatments like chemotherapy or radiation. Participants will have an ovary surgically removed and frozen for future use. Researchers will also study how to improve the freezing and maturati…