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Shorter antibiotic course could spare joint infection patients weeks of treatment

NCT ID NCT01816009

Disease control Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared 6 weeks versus 12 weeks of antibiotics for people with infected hip or knee prostheses who had surgery. Researchers wanted to see if the shorter course was just as effective at curing the infection without increasing relapse. The trial enrolled 410 adults across 34 centers in France and followed them for 2 years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics
What this could lead to
If successful, this could show that a shorter 6-week antibiotic course is just as effective as 12 weeks, reducing side effects and treatment burden for patients with prosthetic joint infections.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all infection types or surgical procedures. Shorter treatment might increase the risk of relapse in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

410 people

The number who actually took part.

Started

Nov 2011

Finished

Jan 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men or women over 18, presenting at least one of the following clinical signs: pain, fever, dent or flow of scar * Bacterial infection on osteo-articular prosthesis (hip or knee) * Documented basterial infection * Surgical care optimized with prothesis change or articular washing * Infection requiring an antibiotic treatment by parenteral way Intravenous injection or per bone * Treatment effective antibiotic begun in the most previously 21 days * Signed consent Exclusion Criteria: * Patient with no proof of osteo-articular infection * No surgical care * Patient having more than one prothesis change because of sepsis * Infection due to mycobactery, fungic infection or brucellienne infection * Patient with life expectancy supposed lower than 2 years * Guardianship patient * Patient included in another study

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Conditions

The condition(s) this trial relates to.

Infections periprosthetic joint infection prosthesis-related infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prosthesis related infections

Contacts and locations

Locations

  • Centre de chirurgie orthopédique et de la main, CHRU de STRASBOURG

    Illkirch-Graffenstaden, France

  • Centre de vaccinations internationales et de médecine des voyages du Tonkin

    Lyon, 69100, France

  • Département de Médecine Interne et Maladies Infectieuses, hôpital privé d'Antony

    Antony, 92160, France

  • Service d'infectiologie, CH de TOULON

    Toulon, France

  • Service de Chirurgie Orthopédique et Traumatologique

    Toulouse, France

  • Service de Chirurgie Orthopédique et Traumatologique, APHP Hôpital Antoine Béclère

    Clamart, France

  • Service de Chirurgie Orthopédique et traumatologie, hôpital Trousseau

    Tours, France

  • Service de Chirurgie orthopédique Hôpital Lariboisière

    Paris, France

  • Service de Maladies Infectieuses et de Médecine Tropicale, Hôpital Pellegrin, CHU de Bordeaux

    Bordeaux, 33076, France

  • Service de Maladies Infectieuses, CH de BOURG EN BRESSE

    Bourg-en-Bresse, France

  • Service de Maladies Infectieuses, CHU de LIMOGES

    Limoges, France

  • Service de Maladies Infectieuses, CHU de REIMS

    Reims, France

  • Service de Médecine Interne et Immunologie Clinique, APHP Hôpital Antoine Béclère

    Clamart, France

  • Service de Médecine Interne et de Maladies Infectieuses, CHRU de TOURS

    Tours, France

  • Service de chirurgie orthopédique et traumatologique, CH de BOURG EN BRESSE

    Bourg-en-Bresse, France

  • Service de chirurgie orthopédique et traumatologique, CHU d'AMIENS

    Amiens, France

  • Service de chirurgie orthopédique et traumatologique, Polyclinique de BLOIS

    Blois, France

  • Service de chirurgie orthopédique, CH de VERSAILLES

    Versailles, France

  • Service de médecine interne et de maladies infectieuses, CHU de BREST

    Brest, France

  • Service de médecine interne, CH de BEZIERS

    Béziers, France

  • Service de médecine interne, PONTOISE

    Pontoise, France

  • Service de médecine interne, maladies infections et tropicales, CHU de POITIERS

    Poitiers, France

  • Service de médecine interne, rhumatologie, Centre Hospitalier Chalon sur Saône William Morey

    Châlon Sur Saone, 71100, France

  • Service de pneumologie - maladies infectieuses et tropicales, CH de ST QUENTIN

    Saint-Quentin, France

  • Service des Maladies Infectieuses et tropicales, CHU de MONTPELLIER

    Montpellier, France

  • Service des Maladies Infectieuses et tropicales, CHU de NANCY

    Nancy, France

  • Service des Maladies Infectieuses, CHU de RENNES

    Rennes, France

  • Service des maladies infectieuses CH Gustave Dron

    Tourcoing, France

  • Service des maladies infectieuses et tropicales - médecine interne, CH de CHAMBERY

    Chambéry, France

  • Service des maladies infectieuses et tropicales CH Saint-Jean

    Perpignan, France

  • Service des maladies infectieuses et tropicales Hôtel-Dieu, CHU de Nantes

    Nantes, 44093, France

  • Service des maladies infectieuses et tropicales, CH de CLERMONT-FERRAND

    Clermont-Ferrand, France

  • Service des maladies infectieuses et tropicales, CHU d'ANGERS

    Angers, France

  • Service des maladies infectieuses et tropicales, CHU de BESANCON

    Besançon, France

  • Service des maladies infectieuses et tropicales, CHU de CAEN

    Caen, France

  • Service des maldies infectieuses, CH d'ANNECY

    Pringy, France

  • Unité de Traumatologie -Orthopédie septique, CHRU de LILLE

    Lille, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.