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Which biologic works best after Anti-TNF failure? study seeks answers

NCT ID NCT01000441

Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the disease over 12 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

300 people

The number who actually took part.

Started

Dec 2009

Finished

Aug 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Active and erosive rheumatoid arthritis with a DAS28 equal or greater than 3.2 * Inadequate response to a 1st anti-TNF * Stable or no treatment with any DMARDs, or oral corticosteroids (\< or = to 10 mg/day of prednisone equivalent)during the preceding month Exclusion Criteria: * Counter-indication to other anti-TNF, abatacept, rituximab or tocilizumab * Pregnancy * Age \< 18 years * Impossibility to give informed consent * Impossibility to be followed for 12 months

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rheumatoid arthritis

Contacts and locations

Locations

  • CH Saint Philibert

    Lomme, France

  • CHRU Lille - Hôpital Salengro

    Lille, France

  • CHU Bordeaux - Hôpital Pellegrin

    Bordeaux, France

  • CHU Chenevier - Mondor

    Paris, France

  • CHU Gabriel Montpied

    Clermont-Ferrand, France

  • CHU Montpellier, Hôpital Lapeyronie

    Montpellier, France

  • CHU de Besançon - Hôpital Jean Minjoz

    Besançon, France

  • CHU de Caen

    Caen, France

  • CHU de Grenoble - Hôpital Sud

    Grenoble, France

  • CHU de Limoges

    Limoges, France

  • CHU de Montpellier - Hôpital Lapeyronie

    Montpellier, France

  • CHU de Nancy - Hôpital Brabois

    Vandœuvre-lès-Nancy, France

  • CHU de Nantes - Hôtel Dieu

    Nantes, France

  • CHU de Nice - Hôpital de l'Archet 1

    Nice, France

  • CHU de Poitiers - Hôpital de la Milétrie

    Poitiers, France

  • CHU de Reims - Hôpital Maison Blanche

    Reims, France

  • CHU de Rennes - Hôpital Sud

    Rennes, France

  • CHU de Rouen - Hôpital Bois Guillaume

    Rouen, France

  • CHU de Saint-Etienne

    Saint-Etienne, France

  • CHU de Toulouse - Hôpital Purpan

    Toulouse, France

  • CHU de la Cavale Blanche

    Brest, France

  • Centre Hospitalier - Princesse Grâce de Monaco

    Monaco, Monaco

  • Centre Hospitalier Départemental Les Oudairies

    La Roche-sur-Yon, France

  • Centre Hospitalier Jean Rougié

    Cahors, France

  • Centre Hospitalier René Dubos

    Pontoise, France

  • Centre Hospitalier Régional d'Orléans, Hôpital de la Source

    Orléans, France

  • Centre Hospitalier de Belfort-Montbéliard

    Belfort, France

  • Centre Hospitalier de Cannes

    Cannes, France

  • Centre Hospitalier de Mulhouse - Hôpital Emile Muller

    Mulhouse, France

  • Centre Hospitalier du Mans

    Le Mans, France

  • Groupe Hospitalier Diaconesses - Hôpital de la Croix Saint-Simon

    Paris, France

  • Groupe Hospitalier du Havre - Hôpital J.Monod

    Le Havre, France

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • Hôpital Bichat

    Paris, France

  • Hôpital Bicêtre

    Le Kremlin-Bicêtre, France

  • Hôpital Jean Verdier

    Bondy, France

  • Hôpital Lariboisière

    Paris, France

  • Hôpital Saint-Antoine

    Paris, France

  • Hôpital de Hautepierre

    Strasbourg, France

  • Hôpital de la Conception

    Marseille, France

  • Hôpital de la Pitié Salpétrière

    Paris, France

  • Hôpitaux Civils de Colmar

    Colmar, France

  • Polyclinique de Picardie

    Amiens, France

  • Polyclinique de Riaumont

    Liévin, France

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Other studies related to the condition(s) this trial covers.