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Could a sedative drug extend pain relief after knee surgery?

NCT ID NCT03834129

Symptom relief Sponsor: CMC Ambroise Paré Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving the sedative drug dexmedetomidine during knee replacement surgery could lengthen the time before patients need additional painkillers. 94 adults having elective knee replacement under regional anesthesia received either the drug or a placebo. The goal was to see if it safely extends pain relief and reduces opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If it works, this could mean longer pain relief after knee replacement, reducing the need for strong opioids.
What could go wrong
This is a small, completed Phase 3 trial. The drug may cause low blood pressure or slow heart rate, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

94 people

The number who actually took part.

Started

May 2019

Finished

Jan 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years and older * Patients undergoing elective total knee arthroplasty * Consent for participation * Affiliation to the french social security system * For women of child bearing potential without contraception, beta-HCG negative result Exclusion Criteria: * Chronic pain syndrome requiring preoperative morphine use (class 3) * Hypersensitivity to dexmedetomidine * Allergy to nonsteroidal anti-inflammatory drugs * Contraindication for locoregional anesthesia * Patient wishing a general anesthesia * Weight\>100 kg, obstructive sleep apnea syndrome or gastrooesophageal reflux complicating the sedation with spontaneous ventilation * Known acute ischemic disease * Severe liver failure * Uncontrolled low blood pressure * Heart rate \< 60 bpm * Advanced cardiac block (Level 2 or 3) except if pacemaker * Pregnant or breastfeeding women * Communication difficulties or neuropsychiatric disorder * Patients under protection of the adults (guardianship, curators or safeguard of justice)

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary total knee arthroplasty

Contacts and locations

Locations

  • Clinique Médipôle Garonne

    Toulouse, Haute-Garonne, 31036, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.