Knee pain relief without surgery? nerve block injections tested
NCT ID NCT07174167
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether injecting numbing medicine around the knee nerves can reduce pain and improve daily function in people with chronic knee osteoarthritis. 81 adults aged 45–75 received either a local anesthetic alone, a local anesthetic plus steroid, or a sham saline injection. Researchers measured pain levels and walking ability over follow-up visits to see which approach worked best.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- prilocaine and triamcinolone
- What this could lead to
- If effective, this nerve block could offer a non-surgical option to ease knee pain and improve mobility for people with osteoarthritis.
- What could go wrong
- This is a small, completed trial (81 people) with short-term follow-up. The effect may be modest or not last long, and results may not apply to everyone with knee OA.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
81 people
The number who actually took part.
- Started
-
Apr 2023
- Finished
-
Jul 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
45 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age between 45 and 75 * diagnosed with knee osteoarthritis (OA) according to the American College of Rheumatology (ACR) criteria * possessing a Kellgren-Lawrence radiological grade of 2-3 Exclusion Criteria: * any joint injection to the target knee in the past 3 months * physical therapy for the target knee within the last 3 months * previous knee surgery * inflammatory rheumatic diseases * active lumbar radiculopathy on the same side * neurological disorders (e.g., Alzheimer's or dementia) * uncontrolled cardiopulmonary diseases * pregnancy or lactation * obesity (body mass index \[BMI\] \>35) * presence of a pacemaker * active malignancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Haydarpasa Numune Training and Research Hospital
Istanbul, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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