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Ultrasound guidance may improve jaw injections for TMJ pain

NCT ID NCT07266714

Symptom relief Sponsor: Muhannad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using ultrasound to guide hyaluronic acid injections into the jaw joint works better than the usual method for people with a displaced jaw disc. Forty adults who had not improved with other treatments received either ultrasound-guided or standard injections. Researchers measured pain, clicking sounds, and jaw movement to see if ultrasound guidance made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronic acid
What this could lead to
If ultrasound guidance proves better, it could become a routine way to improve injection accuracy and reduce jaw pain and clicking.
What could go wrong
This is a small, completed study with only 40 participants. The results may not apply to everyone, and the improvement over standard injections might be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients that will be diagnosed disc displacement confirmed clinically and by Magnetic Resonance Imaging (MRI). 2. Patient not responding to conservative therapy 3. Patients age must be (18 - 50). 4. Patients having painful joint, clicking sound, with or without limited mouth opening. 5. Patient's ability and desire to complete the treatment protocol and follow-up visits. Exclusion Criteria: 1. Patient with an inflammatory or connective tissue disease 2. Patient with previous invasive TMJ surgical procedure. 3. Patient with Neurologic disorders 4. History of injection of any substance into the target TMJ during previous 6 months. 5. Patient with a history of bony adhesion. 6. Malignant disease in the head and neck region. 7. Patient with a psychological problem. 8. Patients having gross mechanical restrictions and condylar fracture

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Conditions

The condition(s) this trial relates to.

temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior disk displacement TMJ

Contacts and locations

Locations

  • Mansoura University

    Al Mansurah, Dakahlia Governorate, 14323, Egypt