Cerebrovascular disorder

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This trial tests whether a home-based virtual reality rehabilitation program called Muvity can improve arm function, balance, and quality of life in people who had a stroke more than six months ago. Participants will be split into two groups: one doing the Muvity program at home …

This trial tests a virtual reality system called RGS that guides stroke survivors through reaching, grasping, and placing virtual objects to aid motor and cognitive recovery. The study enrolls adults who have had a first stroke with mild to moderate arm weakness. Participants use…

This study tested a set of simple, affordable robots called Rehab CARES to help older adults who had a stroke improve arm and hand function. Twenty-seven participants used the robots for one-hour sessions, three times a week for four weeks, while also receiving standard therapy. …

This trial compares two types of technology-assisted balance training for people who had a stroke at least six months ago. One group trains balance using ankle movements, the other uses hip movements, and both also receive a standard rehabilitation program. The goal is to see whi…

This trial tests whether delivering electrical stimulation underwater can help people recovering from a stroke regain hand grip strength and arm movement. Participants who had a stroke within the past six months will receive either real underwater faradic stimulation or a sham ve…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This phase 2 trial tests whether taking colchicine, an anti-inflammatory drug, once daily can prevent major cardiovascular events like heart attacks and strokes in people who have just had a brain bleed (intracerebral hemorrhage). The study includes about 100 adults who have had …

This trial tests whether pairing vagus nerve stimulation (VNS) with rehabilitation can improve arm function in people who have had an ischemic stroke. Participants receive an implanted VNS device and undergo weeks of therapy, with some receiving active stimulation and others a sh…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This trial tests whether a rehabilitation technique called error-augmented walking can improve gait and brain activity in people who have had a stroke. Participants walk on a split-belt treadmill, which makes the two belts move at different speeds to create a deliberate mismatch,…

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This trial tests whether a four-week course of electroacupuncture changes tongue appearance in people recovering from an ischemic stroke. Researchers will use an automated tongue imaging system to capture and analyze tongue color, shape, and coating before and after treatment. Th…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This trial tests whether a specific acupuncture technique, called Xingnao Kaiqiao (or 'Brain Awakening'), can improve arm movement in people recovering from a stroke. It compares this method to standard electroacupuncture. The study involves 66 adults aged 40-80 who had a stroke …

This trial tests whether adding respiratory muscle training to a standard post-stroke wellness program improves breathing strength, physical activity, and quality of life more than the wellness program alone. Stroke survivors who are at least six months post-stroke will participa…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This trial tests whether giving the clot-busting drug alteplase directly into the brain artery, right after a mechanical thrombectomy has reopened a blocked vessel, can improve recovery from acute ischemic stroke. The study enrolls adults with large-vessel blockages in the front …

This pilot study tested whether community pharmacists can manage blood thinner therapy for older adults (60+) with atrial fibrillation who are at high risk for stroke but not on optimal treatment. Fourteen participants received pharmacist-led care for 3 months, then were followed…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This trial tests whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain to help people recover arm and hand function after a stroke. Researchers will try different intensities and frequencies of ultrasound in stroke survivors to find the best settings that…

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery, right after a standard procedure to remove a clot, can help people who have had a severe ischemic stroke. The study includes adults aged 18-85 with a blocked artery in the fron…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tests whether an implanted device that stimulates the vagus nerve, combined with physical therapy, can improve arm movement in people who have had a stroke. The trial includes adults with chronic upper-limb weakness who have already received the implant and completed r…

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls…

This study compares two ways to perform carotid artery stenting—a procedure that opens narrowed neck arteries to prevent stroke. The standard method uses an artery in the groin, while the experimental method uses an artery in the wrist. Researchers will enroll 3000 adults with si…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests a drug called Ir-CPI in 23 people who have had a bleeding stroke (intracerebral hemorrhage). The drug is given once through a vein over 48 hours, alongside standard care. The goal is to see if it is safe and can reduce swelling and further brain damage around the…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) within 6 hours after a stroke procedure (thrombectomy) could prevent early neurological worsening. 60 adults with large-vessel stroke were randomly assigned to receive either the drug plus standard…

This study tested a new device called the Millipede System in 246 stroke patients with large blood clots in the brain. The device is designed to remove clots and restore blood flow. Researchers measured how often blood flow was successfully restored and tracked any side effects. …

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This clinical trial tests whether adding the drug glenzocimab to standard endovascular therapy (a procedure to remove blood clots) improves recovery in people with acute ischemic stroke. The study includes adults aged 18 and older who are eligible for clot removal within 24 hours…

This study tests whether a robotic hand device can help people recovering from a stroke improve hand strength and dexterity better than standard physical therapy. Thirty adults with sub-acute stroke (2 weeks to 6 months post-stroke) will be randomly assigned to receive either rob…

This trial tests whether an experimental drug called Y-3, given as an injection for 10 days, helps people recover better after an acute ischemic stroke. The study includes Chinese adults who had a stroke within the past 48 hours and have moderate to severe symptoms. Participants …

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This study tests whether adding a traditional Chinese herbal decoction (Buyang Huanwu Decoction combined with Wuling Powder) to standard stroke care helps people recover better after an acute ischemic stroke. Participants receive either standard care alone or standard care plus t…

This study tests whether a structured nursing program, based on the Plan-Do-Check-Act quality improvement cycle, can reduce lung infections in stroke patients who have a tracheostomy (a breathing tube in the neck). The program includes careful airway care, suctioning, and early r…

This study compares a virtual reality (VR) rehabilitation program that combines movement and cognitive training in realistic everyday environments with conventional occupational therapy for people who have had a stroke. The goal is to see if the VR program leads to greater improv…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This phase 2 trial tests whether baricitinib, an anti-inflammatory drug, can improve neurological outcomes in people who have had a spontaneous intracerebral hemorrhage (a type of stroke caused by bleeding in the brain). About 110 adults in China will receive either baricitinib p…

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested a new intensive therapy called I-ACQUIRE for infants aged 8 to 36 months who had a stroke around birth and have weakness on one side. The therapy involves guided play and movement exercises for either 3 or 6 hours a day, 5 days a week for 4 weeks. Researchers co…

This pilot study tested a device called Fesia Grasp that uses electrical stimulation to help people recovering from a stroke regain hand function. Sixteen participants with arm weakness after a subacute stroke received either Fesia Grasp therapy or standard physical therapy. The …

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested a new way of caring for stroke patients that brings together doctors, nurses, and family members using technology and teamwork. About 1,200 adults who had a stroke took part. The goal was to see if this coordinated care helps people recover better and have a hig…

This study tested whether using social networks (like family and friends) can help people at high risk for stroke stick to their medications and control risk factors after leaving the hospital. Researchers enrolled 720 patients and compared standard care with a social network-bas…

This study looked at whether a procedure to remove a blood clot from the brain (endovascular therapy) works better than medication alone for people with mild stroke symptoms and a visible clot. About 4,800 adults with mild stroke were included. The goal was to see which approach …

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes i…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This completed study tested a device called MR-001 that uses rhythmic auditory stimulation (like music or beats) to help people who have had a stroke walk better. 234 chronic stroke patients with walking problems used the device at home for 12 weeks. The goal was to see if it imp…

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program could reduce the risk of memory and thinking problems after a stroke. 86 adults who recently had a stroke were randomly assigned to either the home-based brain training or standard care. The program …

This study tested whether a powerful blood thinner called tirofiban can improve recovery in people with a specific type of stroke called branch atheromatous disease (BAD). BAD strokes often get worse quickly and have few good treatments. The trial enrolled 516 adults within 48 ho…

This pilot study tested whether low-frequency magnetic stimulation (rTMS) applied to the brain within 48 hours of an acute ischemic stroke could reduce the growth of damaged tissue and lower disability. Sixty adults aged 18–80 with moderate to severe strokes were enrolled. The tr…

This study tested whether low-frequency magnetic brain stimulation (rTMS) can improve recovery in 60 people who had a severe stroke and received emergency treatment to reopen blocked arteries. Participants received either real or sham stimulation for 3 days after their procedure.…

This study tested two blood thinners—tirofiban and aspirin—in 240 stroke patients who also had a severe blockage in the neck artery. The goal was to see which drug better prevents the artery from reclosing after emergency surgery, while also checking for bleeding risks. Results w…

This early study tested a new device that cools the brain in 8 people who had a stroke caused by a large blood clot. After doctors removed the clot, the device cooled the brain for 30 minutes to try to protect it from further damage. The main goal was to see if the cooling was sa…

This study tested whether using a special tongue brush (Orabrush) can lower the chance of aspiration pneumonia and improve swallowing in people who had a stroke. Researchers enrolled 252 stroke patients and compared those who used the brush to those who did not. The goal was to s…

This study tested whether using a balloon-guided catheter helps doctors remove blood clots more effectively in people having a stroke. 110 adults with acute ischemic stroke were randomly assigned to receive clot removal with either a balloon-guided or standard catheter. The main …

This study looked back at 199 people who already received the Precise Pro Rx stent to treat narrowed carotid arteries (the main arteries in the neck). Researchers wanted to see how well the stent worked and if there were any serious problems like stroke, heart attack, or death. T…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested whether special pelvic floor exercises can help stroke survivors who have weak pelvic muscles and sexual problems. 140 people who had a stroke at least a year ago took part. The goal was to see if these exercises improve muscle strength and sexual function over …

This phase 3 trial tested whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can improve blood flow in stroke patients who still have blockages after standard mechanical clot removal. 156 adults with acute ischemic stroke were randomly assign…

This study tested a simple procedure called remote ischemic conditioning (RIC) in 100 people with narrowed neck arteries who were having surgery to clear the blockage. RIC involves briefly inflating a blood pressure cuff on both arms to temporarily stop blood flow, then releasing…

This study tested a device called the Lariat to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal was to reduce the risk of stroke. Nine participants were enrolled, and the study measured h…

This study looked at 30 adults who had brain surgery after a hemorrhagic stroke and needed blood pressure control in the ICU. Researchers compared two IV medicines, nicardipine and labetalol, to see which one better controlled blood pressure and heart rate during the first 24 hou…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study compares two ways to remove large blood clots from the brain during a stroke: direct aspiration (ADAPT) and using a stent retriever. About 381 adults with stroke caused by a blocked artery in the front part of the brain took part. The goal is to see which method clears…

This study tested whether giving two blood thinners (ticagrelor and aspirin) early, along with standard clot-busting treatment, helps people recover better after a stroke. Over 1,300 patients with mild to moderate stroke were treated within 6 hours of symptoms. The goal was to se…

This study tested whether using a bronchoscope (a thin tube with a camera) to clean the lungs could help people who develop pneumonia and swallowing problems after a stroke. 50 patients were split into two groups: one received standard care, and the other also got 1-2 bronchoscop…

This study tested a procedure called TCAR to treat blocked carotid arteries (major neck arteries). 55 patients with severe blockages were treated, and researchers used brain scans to check for new small brain lesions after the procedure. The goal was to see how safe the procedure…

This Phase 2 trial tested the safety of an experimental drug called RNS60 in 83 people having a severe stroke caused by a large blood clot. Participants received either RNS60 or a placebo as a 48-hour infusion, starting within 30 minutes of consent. The main goal was to check for…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study tested whether intensive, coordinated follow-up by nurses, doctors, and pharmacists over two years helps people recover better after a stroke or heart attack compared to standard care. Researchers enrolled 859 participants and measured quality of life and healthcare co…

This study tested whether adding Mexidol to standard stroke care helps people recover better after a first ischemic stroke. 304 adults who had a stroke within 48 hours were given either Mexidol or a placebo for about 10 weeks. Researchers measured disability, neurological symptom…

This Phase 2 trial tested a drug called LT3001 in 89 people who had an acute ischemic stroke. Participants received either the drug or a placebo within 24 hours of their stroke. The study found no serious drug-related side effects, suggesting LT3001 is safe. Researchers are now l…

This study tested a new expandable coil system for treating medium to large brain aneurysms (both ruptured and unruptured) in 13 adults. The goal was to see if the coil is safe and effectively blocks blood flow into the aneurysm. Results focused on serious side effects and how we…

This Phase 2 trial tested an experimental drug called elezanumab in 121 people who had an acute ischemic stroke. The goal was to see if it could safely improve neurological function and reduce disability compared to a placebo. Participants received the drug or placebo by IV withi…

This study tested whether a 6-month home-based walking program could reduce dangerous bleeding inside carotid artery plaque in people with significant blockages but no stroke symptoms. Fifty-six participants either followed an individualized step goal (with coaching) or received …

This study compared two procedures for treating unruptured brain aneurysms: traditional coiling (using tiny coils to block blood flow) and a newer method using a flow diverter stent. 91 adults with specific types of aneurysms took part. The goal was to see which treatment works b…

This study tested whether stroke patients over 60 with high blood pressure benefit from extra nurse-led education and follow-up, compared to standard care. About 290 patients took part, each bringing a family member or friend to help. The main goal was to see if this approach low…

This study looked at whether getting vitamin D levels above 40 ng/mL after a heart attack could reduce the chance of death, another heart attack, stroke, or heart failure hospitalization. About 634 heart attack patients were split into two groups: one got standard care, and the o…

This study tested a procedure to close a small pouch in the heart (left atrial appendage) in people with atrial fibrillation who are at high risk for both stroke and bleeding. The goal was to see if this procedure works better than standard blood-thinning medications at preventin…

This study tested whether giving the drug tirofiban during stent or flow diverter procedures for unruptured brain aneurysms could reduce the number of small brain injuries seen on MRI after surgery. 192 adults aged 18-80 took part. The goal was to see if tirofiban works better th…

This study tested whether a clot-busting drug called rhTNK-tPA can help people having a stroke when given 4.5 to 24 hours after symptoms begin. It included 570 adults with a stroke that did not involve a large blocked artery. The goal was to see if the drug leads to better recove…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study looked at whether raising the head after a stroke procedure helps patients recover better. Over 1,300 adults with severe strokes were followed for 90 days to see if head elevation improved their ability to function. The goal was to find a simple, low-cost way to boost …

This study looked at 260 people having emergency stroke treatment to remove a clot. Some were given sedation (awake but relaxed) and others were put under general anesthesia (completely asleep). The goal was to see which approach leads to better recovery and fewer complications a…

This study tested a procedure called rapid local ischemic postconditioning in 25 people who had a stroke and successful clot removal. Right after reopening the blocked artery, doctors briefly inflated and deflated a balloon in the neck to temporarily stop blood flow, aiming to he…

This study looked at 391 people with a type of stroke caused by a blockage in a major brain artery, treated 4.5 to 24 hours after symptoms started. Half got a clot-busting drug called tenecteplase followed by a mechanical clot removal procedure, while the other half had the proce…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening in 121 people with ANCA-associated vasculitis. Participants were in remission and received either rosuvastatin or a placebo for up to 2 years. The goal was to …

This phase 3 study tested whether high doses of erythropoietin, a hormone that boosts red blood cell production, could improve survival and brain development in full-term newborns who suffered oxygen deprivation at birth. All 120 babies also received standard cooling therapy. The…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested whether sildenafil, a drug used for erectile dysfunction, can reduce harmful pulsations in brain blood flow in 75 people who had a stroke or mini-stroke due to small vessel disease. Participants took sildenafil, a similar drug (cilostazol), or a placebo for thre…

This pilot study tested a procedure to close the left atrial appendage—a small pouch in the heart where clots often form—in 58 patients with atrial fibrillation who had a prior brain bleed and cannot take standard blood thinners. The goal was to see if this approach could reduce …

This early-stage study tested a drug called PP-007 in 24 people having an acute ischemic stroke. The drug is designed to carry oxygen to the brain. Researchers checked if adding it to standard treatments like clot-busting drugs or clot removal was safe. The goal was to see how th…

This study tracked 949 patients with non-valvular atrial fibrillation who received the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to reduce stroke risk. The goal was to see how well the device works in everyday medical practice, focusing on safet…

This study tested whether the drug Mexidol (given first as injections, then as pills) can improve thinking and memory in people with chronic cerebral ischemia, a condition where the brain doesn't get enough blood flow. 318 adults aged 40-90 with mild to moderate cognitive impairm…

This study looked at how safe and effective the OPTIMA coil system is for treating brain aneurysms. Researchers followed 300 patients across Europe for up to 12 months after the coiling procedure. They tracked complications like bleeding, blood clots, and the need for repeat trea…

This study looked at whether using a device to measure pressure inside the skull helps doctors treat people with a large brain bleed. 193 patients were randomly assigned to get either standard care or care guided by the pressure monitor. The goal was to see if the monitor helped …

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a new tool called BESTA, designed to quickly diagnose aphasia (language problems) in people who just had a stroke. Researchers compared BESTA to an existing test in 395 participants, including stroke patients and healthy volunteers. The goal was to see if BESTA …

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study tested whether a non-invasive device placed on the forehead (NIRS) can detect blood vessel spasms in the brain after a severe aneurysm rupture. Fifty patients were monitored continuously from day 4 to day 12 after their bleed. The goal was to see if this oxygen-measuri…

This study tested whether a special CT scan done in the procedure room can accurately detect bleeding in the brain of stroke patients. The goal is to speed up diagnosis and treatment by avoiding extra trips to the regular CT scanner. 252 adults with stroke symptoms were enrolled …

This study looked at whether a special type of CT scan (dual-energy CT) can more accurately tell the difference between bleeding and harmless contrast dye in the brains of stroke patients after treatment. About 189 adults who had a stroke and received clot-busting drugs or a clot…

This study tested a device called NIRSITX that uses light to measure oxygen levels in the brain. Researchers compared oxygen readings from the injured side of the brain to the healthy side in 35 adults who had a stroke within the past week. The goal was to see if the device could…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study tested a new thinking test called CASP for stroke patients. The test is designed to work even for patients who have trouble speaking after a stroke. Researchers checked how well the test works by comparing it to other tests in 263 patients.

This study looked at whether a panel of blood biomarkers can quickly identify stroke patients who have a large vessel occlusion (a major blockage) and would benefit from a specialized clot-removal procedure. Researchers enrolled nearly 3,900 adults with stroke symptoms and tested…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tested a new way to position the weak arm in stroke patients to prevent shoulder pain, a common problem that can slow recovery. 76 people who had a stroke within the last 48 hours took part. The program used special supports and slings, along with training for patients…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This completed clinical trial tested a procedure called ischemic postconditioning to prevent brain damage in 40 people undergoing carotid surgery for severe artery narrowing. The procedure involves briefly clamping and unclamping the carotid artery in cycles after surgery to prot…

This study looked at whether a simple oral hygiene routine could prevent a serious lung infection called aspiration pneumonia in people hospitalized after a stroke. Researchers compared 90 stroke patients who received structured mouth care from nurses to similar patients who got …

This study tested a new daily pill called asundexian in over 12,000 people who recently had a stroke or mini-stroke caused by a blood clot from outside the heart. The goal was to see if adding asundexian to standard antiplatelet therapy could prevent another stroke without increa…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

Researchers are testing a 12-week home-based programme that combines aerobic exercise, strength training, stretching, and self-management education for people who had a stroke more than six months earlier. The trial enrolls 30 community-dwelling survivors aged 20 to 59 who can wa…

Researchers are testing whether a dual-task exercise program helps stroke survivors walk while doing a mental task. The study compares dual-task training, which combines walking with cognitive activities, to single-task training, where walking and thinking are practiced separatel…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study tests whether dry needling (inserting thin needles into tight muscles) can reduce spasticity—stiffness that makes movement hard—in people who have had a stroke. About 28 adults who can walk independently will receive either real or sham (fake) needling once a week for …

This trial tests a support package called CaknaStrok for people caring for a family member who just had a stroke. The package includes a mobile app with videos and tools, plus a guidebook, all tailored for Malaysian caregivers. Researchers compare caregivers who get the package w…

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 participants who had a stroke 3 months to 1 year ago will do either isokinetic knee exercises or standard rehab. The goal is …

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

Researchers are testing whether an electromyography-controlled functional electrical stimulator (FitFES) helps stroke survivors regain arm and hand function. The device reads muscle signals and delivers electrical stimulation during task-oriented exercises. Fifty adults who had a…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

Stroke often damages trunk control, balance and walking ability. Researchers are testing whether combining transcranial direct current stimulation, a mild electrical current applied to the scalp, with pelvic proprioceptive neuromuscular facilitation, a hands-on stretching and mov…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests a rehabilitation method called modified constraint-induced movement therapy (mCIMT) for people recovering from a stroke. Participants wear a mitten on their unaffected arm for several hours a day while practicing tasks with the affected arm. The goal is to see if…

This study tests whether wearable sensors and goal-setting sessions with a physiotherapist can help stroke survivors stay active after leaving inpatient rehabilitation. Participants wear sensors to track activity, sleep, and sedentary behavior, and some receive feedback and set g…

This study tests whether intensive robotic arm training can help people recovering from a stroke improve arm movement and reduce stiffness. Participants will use two types of robotic devices in 12 sessions over four weeks. Researchers will also use a technique called muscle syner…

This trial explores whether exposure to artificial light that mimics natural sunlight can improve brain activity, heart rate regulation, and movement in people who have had a stroke. Thirty chronic stroke survivors will undergo light sessions while their brain waves and heart rhy…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. Fifty participants will receive ECT sessions with anesthesia, and researchers will m…

This study tests a new therapy that uses moving sounds to help stroke survivors with spatial neglect — a condition where they ignore one side of space. 18 participants will either get standard rehab or standard rehab plus dynamic auditory cueing for 4 weeks. The goal is to see if…

This study tests whether health education videos redesigned using semiotics—the science of signs and symbols—can help stroke survivors improve daily activities, sleep, anxiety, and depression. Two hundred stroke patients will be randomly assigned to watch either these optimized v…

This study tests whether a home-based occupational therapy program using video calls and activity monitoring can help older stroke survivors improve their daily functioning and self-management. Researchers will compare this approach to standard care in 171 participants over 26 we…

This completed trial tested whether brief, moderate-to-vigorous physical activity sessions combined with health education could increase exercise in stroke survivors. 36 adults aged 50 and older who had a stroke and lived at home took part. Participants wore an accelerometer to t…

This study tests whether balance exercises that challenge the senses (like closing eyes or standing on uneven surfaces) can improve balance and reduce fall risk in people who had a stroke over 6 months ago. 46 participants will be split into two groups: one doing these special ex…

This study tested whether fast arm movement training helps people who had a stroke regain arm function better than standard accuracy training. 44 chronic stroke survivors with mild to moderate arm weakness participated. The training focused on moving quickly, and researchers meas…

This study tested whether adding mental practice of swallowing to standard therapy helps people who have trouble swallowing after a stroke. 43 adults were split into three groups: one watched swallowing videos then imagined the action, one just imagined swallowing, and one had on…

This study tested a new occupational therapy program called PRO-MAMA for older mothers (70+) who have had a stroke. The program focuses on helping them take part in meaningful activities related to their role as a mother. Fourteen women completed the program, and researchers meas…

This study tested a new occupational therapy called HABIT, designed to help stroke survivors use their affected hand more in everyday activities. Eleven adults with mild hand weakness after stroke participated. Researchers measured hand use and satisfaction with daily tasks befor…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This study compared two non-invasive therapies—radiofrequency (TECAR) and ultrasound—for treating shoulder pain in 45 stroke survivors. Participants had shoulder pain for at least 3 months after their stroke. Researchers measured pain, range of motion, and daily function to see w…

This study tested a mobile robot designed to help people who have had a stroke regain their ability to walk. 37 stroke survivors used the robot for 16 sessions along with their usual physical therapy. The goal was to see if the robot improved their balance and walking more than s…

This study tested whether combining somatotherapy (body awareness and movement exercises) with occupational therapy (training in daily tasks like dressing and cooking) could improve cognitive function in 50 adults who had a stroke. Participants received 35-minute sessions five da…

This study tested whether adding gentle sensory stimulation (like light touch and tapping) to standard physical therapy could improve facial symmetry and function in people with facial palsy after a stroke. Thirty-six participants were split into two groups: one received both sen…

This pilot study tested a wearable grasping neuroprosthesis in 6 people with hand weakness after a stroke. Participants used the device at home daily to help with gripping tasks. The study focused on how often people used it and whether it was practical and helpful in real life.

This study looked at 39 adults who had arm stiffness (spasticity) after a stroke. Researchers compared different types of transcranial magnetic stimulation (TMS) combined with Botox injections to see which worked best. The goal was to reduce muscle tightness and improve arm movem…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study tested whether a virtual reality shopping game could help stroke survivors improve their daily living skills. Twenty-nine adults who had a stroke 1 to 18 months earlier participated. One group practiced shopping in a virtual supermarket, while the other did standard co…

This pilot study tested whether adding virtual reality (VR) exercises to standard rehabilitation helps people who recently had a stroke recover their thinking skills and ability to do daily tasks. Thirty-six adults with acute stroke and mild cognitive impairment were assigned to …

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested low-level laser therapy (LLLT) on 18 chronic stroke patients with ankle stiffness. Half got laser plus physiotherapy, half got physiotherapy alone for three weeks. Both groups improved, but the laser group had greater reductions in muscle tightness and better wa…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study looked at whether adding robot-assisted walking training to stationary cycling helps people who recently had a stroke and are losing muscle. 53 participants did either cycling alone or cycling plus robot walking for 4 weeks. The goal was to see if the combination impro…

This study tested whether a set of exercises called FAST (Fast muscle Activation and Stepping Training) can improve walking balance in people who had a stroke. 55 participants who had a first stroke within the past 6 months and had leg weakness took part. They did 12 sessions of …

This study tested whether 3 weeks of intensive language therapy (at least 2 hours daily, 5 days a week) helps people with long-term aphasia after a stroke communicate better in everyday situations. 156 participants with aphasia for at least 6 months were assigned to either immedi…

This study tested a powered hip exoskeleton for gait training in 32 people who had a stroke at least 3 months earlier. Participants used the device for 10 sessions over 5 weeks. The main goal was to check safety and see if walking speed improved.

This study tested a device called MyoRegulator® to see if it can reduce muscle stiffness (spasticity) in the lower leg after a stroke. 44 adults who had a stroke at least 6 months earlier took part. Half received real treatment and half received a sham (fake) treatment for 5 days…

This study tested the safety and effectiveness of repeated MYOBLOC injections over one year in 187 adults with troublesome drooling caused by conditions like Parkinson's disease, stroke, or ALS. Participants received up to four treatment sessions, and researchers tracked side eff…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This study tested a new program called CATCHES for people who had a stroke and are afraid of falling. The program combines physical therapy at home with coaching to reduce fear. 30 adults who had a mild to moderate stroke took part. The goal was to see if the program is practical…

This study tested a device called recoveriX that uses a brain-computer interface, electrical stimulation, and virtual reality to help stroke survivors improve their walking. Thirty participants who had a stroke at least six months ago were split into two groups: one used the full…

This study tested whether mirror therapy can reduce pain and improve movement in stroke patients who also have complex regional pain syndrome (CRPS). Forty adults who had a stroke within the past year and were diagnosed with CRPS took part. They received either real mirror therap…

This study tested two methods to help people regain arm movement after a stroke: looking at a mirror to trick the brain, or using a robotic hand glove that mimics the healthy arm. Thirty adults who had a stroke within the past year took part. Both groups also received standard ph…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study looked at whether a mother's scent and a soft, knitted octopus toy could reduce pain in newborns who had a lack of oxygen at birth (asphyxia) and were receiving cooling treatment. The study included 45 full-term babies in intensive care. Researchers measured pain level…

This study tested a non-invasive brain stimulation technique called continuous theta-burst stimulation (cTBS) in 60 people who had a stroke within the past two weeks and had moderate to severe arm weakness. The stimulation was guided by brain scans to target areas involved in mov…

This study tested whether combining motor imagery (thinking about moving without actually moving) with a type of brain stimulation called TMS could help people who had a stroke regain arm function. 24 adults who had a stroke at least one month prior participated. The goal was to …

This small pilot study tested whether a gentle electrical current applied to the brain (tACS) could improve naming ability in 11 people with chronic aphasia after a stroke. Participants received either real or sham stimulation during language training over two weeks. The goal was…

This study tested whether specialized sexual nursing care could help stroke patients and their partners manage sexual difficulties. Thirty stroke survivors and their partners were split into two groups: one received personalized counseling and education from trained nurses, while…

This study looked at whether starting more frequent or intense physical therapy within the first day after a stroke helps patients regain movement and balance. 102 adults with acute stroke were split into groups receiving standard care, more sessions, harder exercises, or both. R…

This study looked at whether listening to self-chosen Italian music during and after a stroke hospital stay can improve mood, reduce anxiety and depression, and boost overall well-being. 150 stroke patients were randomly assigned to either regular music listening or standard care…

This study tested whether using a video game called MindPod Dolphin is safe and practical for arm rehabilitation in people who recently had a stroke. 58 participants played the game, controlling a dolphin with their affected arm. The goal was to see if patients would stick with i…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blo…

This study tested two ways to do extra arm exercises after a stroke: a custom program designed by a therapist, or using a special movable wheelchair armrest (called Boost). 35 people in acute rehab took part. The goal was to see which method better improves arm movement and reduc…

This completed study tested the EXOPULSE Mollii suit, a full-body garment with 58 electrodes, in 30 stroke survivors who had muscle stiffness (spasticity) and balance problems. The suit stimulates muscles to reduce spasticity and improve balance. Researchers measured balance chan…

This study looked at whether adding a 15-minute vibration treatment to a standard arm skill program helps people who had a stroke 3-6 months ago. 60 participants were split into two groups: one got the vibration plus training, the other got training alone. Researchers measured ar…

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested two non-invasive treatments—high-intensity laser therapy (HILT) and extracorporeal shock wave therapy (ESWT)—to reduce calf muscle stiffness and improve walking in 39 people who had a stroke at least three months earlier. Both therapies aim to relax spastic musc…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested whether intensive upper limb rehabilitation helps people who had a stroke at least 6 months ago. 105 participants were randomly assigned to one of two intensive therapy programs or usual care. The goal was to see if high-dose training improves arm movement and f…

This pilot study tested a wearable robotic arm device (NESM-α) in 7 stroke survivors to see if it is safe and feasible for rehab. The robot adjusts to each person's ability, providing gentle assistance during movement. The main goals were to check for side effects and see if pati…

This study looked at whether different types of physical exercise can help adults recover from a mild traumatic brain injury (concussion). 37 adults who had a concussion within the past year took part in a 3-month program of either balance or aerobic exercises. Researchers measur…

This study tested whether kinesio taping (a special elastic tape placed on the skin) can improve arm and hand function, reduce pain, and boost mood in people who recently had a stroke. 26 adults with arm weakness were randomly assigned to get either real kinesio taping or a fake …

This study tested a problem-solving program delivered by phone and online for Spanish-speaking caregivers of veterans who had a stroke. The program taught caregivers the COPE model (Creativity, Optimism, Planning, Expert Advice) to help them manage caregiving challenges. Research…

This study tested two types of arm exercises in 26 people who had a stroke and had trouble using one arm. One type used automatic movements (where the target moves to guide the arm), and the other used intentional movements (where the target stays still). The goal was to see whic…

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support to reduce hospital transfers and improve symptom co…

This study looked at whether a long-term exercise program can help people with dementia living in nursing homes keep their ability to do daily tasks like bathing and dressing. 140 participants were split into an exercise group and a social activity group. The goal was to see if e…

This study tested whether adding ear acupuncture (auricular thumbtack needle therapy) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with a Glasgow Coma Scale score of 4-8 were randomly assigned to receive…

This study looked at 34 adults with acute ischemic stroke and very high blood pressure. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure faster before stroke treatment. The goal was to find the best way to quickly and safely get b…

This study tested whether adding virtual reality (VR) exercises to standard physical therapy helps people who recently had a stroke recover arm and hand function better than therapy alone. Fifty-two adults with a first-time stroke and some remaining arm movement took part. Resear…

This study tested whether a specially designed occupational therapy program could help people with mild-to-moderate thinking problems after a stroke perform daily activities like dressing or cooking. Only 8 people took part, and the goal was to see if the therapy was practical to…

This study tested a device that uses mild electrical pulses to stimulate finger muscles in stroke survivors who cannot open their hand. The goal was to see if it helps them grasp, move, and release objects like a glass or spoon. Eleven people with chronic stroke participated, and…

This study tested whether giving a very high dose of lovastatin (a common cholesterol drug) for 3 days after a stroke is safe. 162 stroke patients received either the high-dose drug or a placebo within 24 hours of symptoms. The main goal was to check for liver or muscle damage, w…

This study tested speech entrainment therapy (SET) in 80 people with non-fluent aphasia after a stroke. Participants practiced speaking along with an audio-visual computer program for 3, 4.5, or 6 weeks, or received no therapy. The goal was to find the best duration for lasting i…

This study tested a 'wisdom enhancement' technique added to standard therapy for depression after a stroke. Three stroke survivors tracked their mood, identity, self-esteem, and wisdom daily. The goal was to see if this approach could improve emotional well-being, but the very sm…

This study tested a new way of caring for people with Parkinson's disease. The goal was to help 214 participants achieve their personal goals and improve their quality of life. The approach involved proactive, integrated care and patient empowerment, compared to standard care.

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This study tested whether wearing a weighted brace on the unaffected ankle for three months helps people who have had a stroke walk farther. Forty-two participants who had a stroke more than three months ago but less than five years ago took part. Half wore a weighted brace (2-4 …

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

This study tests two leg devices—the geko® nerve stimulator and an intermittent pneumatic compression (IPC) sleeve—to see if they increase blood flow to the brain in people who recently had an ischemic stroke. Eighty adults within 36 hours of stroke onset will use one of the devi…

This completed study looked at how brain lesions from strokes impact cognitive control—the ability to focus, switch tasks, and make decisions. Researchers tested 184 healthy adults and stroke patients using behavioral tasks, brain scans (MRI), and EEG. The goal was to understand …

This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for pe…

This study used a non-invasive brain stimulation technique called TMS to measure how the motor cortex responds in people who have had a stroke. Researchers compared brain excitability between 24 stroke survivors and healthy individuals. The goal was to better understand how strok…

This study looks at 100 people having a mechanical thrombectomy (clot removal) for a major stroke. Researchers will monitor their blood sugar continuously during the procedure and check recovery 3 months later. The goal is to see if lower blood sugar at the time of reperfusion (w…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study tested two advanced rehabilitation devices—a treadmill and an overground walking trainer—to help 80 stroke patients regain their ability to walk. Participants used either the C-Mill treadmill or the Andago overground device alongside standard therapy. The goal was to s…

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

Researchers at the University of Ioannina are studying stroke patients who have both movement and vision problems. They will evaluate each patient twice, once shortly after the stroke and again weeks later, to measure how these deficits change. The goal is to see whether improvem…

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study tests whether a practice resource called PReDAS helps occupational therapists who work with stroke patients feel more confident and make better decisions about driving. Eight occupational therapists on acute stroke units will receive the resource and a one-hour trainin…

This trial is testing whether an artificial intelligence (AI) tool can accurately predict how patients with acute ischemic stroke will recover. The AI analyzes patient data in real time to forecast outcomes, such as functional disability, which is then compared with the actual ou…

This study is testing whether an advanced ultrasound technique can identify which carotid artery plaques are dangerous (vulnerable) and likely to cause a stroke. Researchers will compare ultrasound images taken before surgery with the actual plaque tissue removed during the opera…

This completed study looked at how a person's total daily-life exposure—called the 'exposome'—affects health after a stroke. Researchers tracked 150 stroke survivors, measuring biological, environmental, social, and lifestyle factors alongside motor and cognitive tests. The goal …

This study tests whether a specialized training program called off-script diagnosis and differential diagnosis (D&D) training can improve neurology residents' ability to diagnose and manage acute ischemic stroke. The training focuses on structured analysis of stroke causes, mimic…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study investigates how brain activity changes when people imagine moving their wrist. Researchers will use advanced brain scans (MRI and MEG) to create personalized models of these signals, then test if they can decode imagined movements using simpler EEG recordings. The goa…

This study compares three devices that measure how well blood clots — ClotPro, ROTEM, and TEG — in patients undergoing liver surgery, neurosurgery, or cesarean section. The goal is to see how closely the results from these devices agree with each other. The findings may help doct…

This study looks at how certain immune cells (neutrophils) behave in people having a severe stroke. Researchers want to find the best time and target for treatments that block these cells. 440 adults having emergency stroke treatment will give blood samples and have their recover…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study looks at medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. The goal is to understand which treatments are used and how often serious bleedin…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This study looked at why some people have trouble balancing while sitting after a stroke. Researchers used a special pressure-sensing pad and motion trackers to measure how 32 stroke survivors shifted their weight and moved their head and trunk. The goal was to better understand …

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach b…

This study looked at whether a substance in the blood called D-dimer can help predict how well people recover after a stroke. Researchers measured D-dimer levels in 102 stroke patients who had received treatment to restore blood flow. They then compared these levels with standard…

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This completed early-phase study looked at how sex and stress influence blood flow in the brain. Researchers gave 42 healthy young adults indomethacin (an anti-inflammatory drug) or a placebo to test whether a specific mechanism (COX signaling) explains differences between men an…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study tested a new, powerful MRI scan on 56 stroke patients to see if it could detect subtle brain damage not visible on standard scans. The goal was to better understand how much brain tissue is truly saved after treatment. The findings could help doctors predict recovery m…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This study looked at 31 full-term newborns with brain injury from lack of oxygen (hypoxic-ischemic encephalopathy). Researchers used a special MRI technique called arterial spin labeling to measure blood flow in the brain during the first week of life. The goal was to see if this…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This study looked at 232 people with cerebral venous thrombosis, a rare stroke that mainly affects young women. Researchers took blood samples at several time points to measure markers of clot formation and breakdown. They wanted to see if these markers relate to how the disease …

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This study translated the Fugl-Meyer assessment, a test that measures movement and function after a stroke, into Turkish and checked if it works correctly. Researchers tested 80 stroke patients in Turkey to see if the Turkish version is reliable and accurate. The goal was to give…

This study asked stroke survivors, caregivers, and healthcare professionals what they need from a home-based rehabilitation system called NEST. The system includes an exercise app, a smartwatch, and a virtual coach. Researchers held focus groups and interviews in Italy, Spain, an…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study tested whether a special PET scan can predict delayed brain damage in people who had a bleeding stroke from a burst aneurysm. 35 participants received a PET scan within days of their stroke to measure how their brain cells take up sugar, which reflects blood flow. The …

This study observed 141 people in German stroke units who had a brain bleed while taking the blood thinners rivaroxaban or apixaban. Researchers wanted to see if giving the reversal drug andexanet alfa could stop the bleed from getting bigger. They tracked changes in bleed size o…

This study looked at what makes it easier or harder for veteran stroke survivors to do arm and hand exercises at home. Researchers gave surveys about mood, confidence, and sleep, then used a wearable tracker to measure exercise. The goal is to find ways to help people stick with …

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study used ultrasound to look at the shape and structure of spastic muscles in the arms and legs of 80 stroke survivors. The goal was to see if ultrasound can help doctors better understand and measure muscle changes after stroke. The findings may improve how spast…

This study looked at how blood moves through leg muscles in people who have had a stroke compared to healthy adults. Researchers used gentle leg movements and muscle contractions to measure blood flow. The goal was to learn more about why stroke survivors often have reduced exerc…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study looked at how the brains of people with aphasia (a language disorder after stroke) and healthy people work together during gestures. Using EEG, researchers measured brain synchronization while participants watched and copied different types of gestures. The goal was to…

This study looked at 332 stroke patients to see if general anesthesia or conscious sedation is better during a procedure to remove blood clots from the brain. The goal was to find which method leads to better recovery and fewer complications within the first week. The results cou…

This study compared two types of anesthesia—propofol alone versus a mix of propofol and ketamine—in 46 adults having elective surgery for unruptured brain aneurysms. Researchers measured the diameter of the optic nerve sheath (a marker of brain pressure) at several points during …

This study followed 82 people with blocked arteries supplying the back of the brain to see if low blood flow raises the risk of stroke or mini-stroke. Participants had already experienced a stroke or transient ischemic attack (TIA) and had at least 50% blockage in those arteries.…

This study tested whether wrist-worn accelerometers can accurately measure how much stroke patients use their weaker arm during everyday activities like dressing and eating. Twenty-five participants were recorded with both accelerometers and video cameras. The goal was to see if …

This study looked at 55 stroke survivors to see if reducing sitting time early after stroke helps with walking and daily function. Researchers also checked if brain scan markers can predict who benefits most from rehab. The goal is to create personalized recovery plans based on e…

This study tested whether a 1-minute 51-second animated video called FAST BEE helps people learn and remember stroke warning signs. Over 300 healthy adults and teens watched the video and then answered questions about what they learned. The goal was to see if the video improves r…

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This study looked at 70 people who had a brain hemorrhage (bleeding stroke) to see if a special PET scan could tell whether the bleeding was caused by amyloid buildup in blood vessels or by high blood pressure. Participants received an injection of a radioactive tracer called Flo…

This completed study followed over 31,000 people in China who had unruptured brain aneurysms (a bulge in a blood vessel that hasn't burst). Researchers compared four approaches: simply monitoring the aneurysm, surgical clipping, coil embolization, or flow diversion. The goal was …

This study checked how well the Fugl-Meyer Assessment (a test for stroke recovery) works in people recovering from a stroke. Over 100 patients in rehab were tested when they arrived and when they left. The goal was to see if the test accurately tracks improvement.

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This completed study looked at how leg muscles work during walking in 500 people who had a stroke. The goal was to understand muscle patterns, test how well current measurement methods work, and find early signs that predict walking recovery. The results could help doctors create…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This study looked at how doing a thinking task while walking affects the brain in people who have had a stroke. Eleven stroke survivors walked on a special mat while a brain scanner measured their brain activity. The goal was to understand why walking gets harder when you have to…

This study tested a program to help people with stroke or TIA transition from hospital to home. 213 participants received either the program or usual care. The program focused on improving communication, health literacy, and medication management. Researchers measured quality of …

This study worked with 49 stroke patients, their families, and healthcare teams to design and test a more personalized way to move from the hospital to home rehabilitation. The goal was to improve the quality of care transitions and health literacy. The study did not test a treat…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study tested whether a special MRI scan called IVIM can predict how well people recover three months after an acute ischemic stroke. Researchers added a two-minute scan to the standard MRI for 274 adults admitted with stroke. They then compared the scan results to the patien…

This study looked at 174 adults who had a stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better functional recovery after 90 days. The goal is to find the best time to take patie…

This study tested whether raising the legs (elevated leg positioning) is safe and practical for people who have had a moderate ischemic stroke. Fifty adults with moderate stroke symptoms were enrolled within 24 hours of symptom onset. The goal was to see if this simple, non-drug …

This study looked at 70 family caregivers of stroke patients who also have bladder issues. Researchers measured how much burden, fatigue, poor sleep, and depression caregivers experience. The goal was to understand the challenges these caregivers face, not to test a new treatment…

This completed study tested whether mild electrical stimulation of the outer ear (taVNS) can change how brain regions communicate in people who had a stroke more than 6 months ago, as well as in healthy adults. Researchers used a brain-imaging technique called fNIRS to measure re…

This study looked at 50 people who had a mild stroke to understand why they might struggle with everyday activities like work, hobbies, or socializing. Researchers wanted to see if factors like mood, fatigue, or thinking problems make these gaps worse, and if having more gaps low…

This study tested whether telephone interviews after a stroke can help patients better understand and follow their medication plans. 54 adults who had an ischemic stroke and were returning home received a pharmaceutical interview before discharge, followed by phone calls at one w…

This study looked at brain activity in 64 people (some who had a stroke and some healthy) while they moved their arms with different levels of effort. The goal was to understand how the brain responds during rehabilitation exercises. Researchers used a special brain scanner (fNIR…

This study measured levels of a brain protein called BDNF in 50 stroke patients who received a clot-busting drug. Researchers wanted to see if BDNF levels rise after treatment and if they could help predict recovery of movement, thinking, and mood three months later. The goal is …

This study looked at 1499 people who had an acute ischemic stroke and got a chest CT within 24 hours. Researchers wanted to see if combining CT findings with clinical signs and inflammation markers could better predict who would develop pneumonia within a week. They built and tes…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 167 people with atrial fibrillation or flutter who had a catheter ablation procedure. Researchers measured changes in stroke and bleeding risk scores before and 3, 6, and 12 months after ablation. They also compared different monitoring methods, including impl…

This first-in-human study tested a new smart guidewire (Clotild®) in 45 stroke patients undergoing emergency clot removal. The wire helps guide the removal tool and also measures the clot's electrical properties to determine its composition. The main goal was to check safety, suc…

This study checked if a Turkish version of the Bolus Residue Scale (BRS) is a reliable way to measure swallowing problems in people who recently had a stroke. Researchers looked at video recordings of 40 patients swallowing and had experts rate the results. The goal was to make s…

This completed study involved over 36,000 patients and aimed to create quality indicators for stroke and chronic coronary syndrome care using French national health databases. Researchers linked patient data from practice registries to the national database to validate these indi…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This study tested two heart monitoring methods in 516 people who had a transient ischemic attack (TIA or mini-stroke). The goal was to see which method better detects hidden atrial fibrillation, a heart rhythm problem that raises stroke risk. Participants received either a small …

This study looked at 126 people who recently had a stroke caused by a blocked blood vessel in the brain. Researchers wanted to find out how common fatigue is after a stroke and what factors might be linked to it, including any treatments given in the first days. Participants comp…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This study looked at whether doctors, nurses, or standard risk scores are better at predicting long-term recovery after a brain hemorrhage. Over 1,000 patients were followed for 6 months. The goal is to improve how we estimate outcomes for these serious conditions.

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This study looked at whether online training can improve how well emergency department doctors interpret CT head scans. 173 clinicians from 6 UK hospitals took part. One group received training early, while a control group got it later. The goal was to see if training boosts accu…

This study aimed to better understand why some people develop delayed brain damage after a brain aneurysm rupture. Researchers measured platelet activation over time in 90 patients, comparing those with aneurysm bleeds to those with other types of brain bleeds. The goal was to cl…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This completed study tested a program to help stroke survivors in rural Kentucky take their blood pressure medications as prescribed. Four participants received one-on-one education and tailored sessions from a pharmacy technician and community health worker. The goal was to see …

This study looked at 79 people with a rare type of stroke caused by calcified particles traveling to the brain. Researchers used CT scans to describe the size, location, and density of these particles, and compared patients' medical histories and risk factors. The goal was to bet…

This study tested a new way to assess and train balance using a reaching task. Seven people, including stroke survivors and healthy adults, took part. They stood and pointed at a moving target on a screen, which challenged their balance. The goal was to see if this method could s…

This study looked at how different types of exercise (interval vs. continuous) and intensity levels (moderate vs. high) affect aerobic fitness and blood vessel health in people who have had a stroke. 59 participants used a seated stepper that moves both arms and legs. The goal wa…

This study followed 170 older adults who had a type of stroke caused by cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels. Researchers wanted to see if a specific finding on MRI scans, called cortical superficial siderosis (cSS), could …

This study followed 200 stroke patients aged 18 to 64 during inpatient rehabilitation. Researchers checked how well standard tests like the Functional Independence Scale and Mini Mental State Exam describe recovery using the ICF framework. The goal was to understand current monit…

This study reviewed medical records of 274 adults who had emergency surgery for a torn aorta (aortic dissection). Researchers looked at how often patients had brain complications like stroke or coma after surgery and whether those complications led to longer stays in the intensiv…

This study tested a new device called a hybrid neuroprosthesis to help people who have had a stroke move their arm better. 24 adults with arm weakness after a stroke used the device in rehab sessions. The goal was to see if the device was easy to use, safe, and helpful, not to cu…

This study looked at how the brain responds when people exercise while breathing low-oxygen air (like at high altitude). Thirty healthy men did exercise tests while researchers measured brain and muscle activity using special scans and stimulation. The goal was to understand why …

This study looked at how well the ReVive™ SE device works to restore blood flow in the brain during a stroke. Only one patient took part, and the goal was to see if the device is useful in standard care. The main measure was how much blood flow returned after using the device.

After a stroke, many people can move their affected arm but choose not to, a condition called non-use. This study tested 53 participants (stroke survivors and healthy controls) to see how the need for force or precision affects arm use. Researchers used a weight-support system to…

This study observed 20 stroke patients with hemiplegia (weakness on one side) as they walked 10 meters. Researchers used sensors and a special walkway to measure foot movements and timing. The goal was to gather data that could help improve when functional electrical stimulation …

This study looked at how much people who had a transient ischemic attack (TIA or mini-stroke) understand about their condition after being treated in the emergency room. About 100 adults in Lyon, France, answered a questionnaire to test their knowledge of symptoms, risk factors, …

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked back at the medical records of 200 people who had artery repair surgery using the Uni-Graft K DV patch. The goal was to see how often the artery narrowed again after surgery and to check for any bleeding or strokes. The study did not give any new treatment, but …

This study looked back at data from 50 patients with severe brain injuries (from trauma or bleeding) who were treated in the ICU. Researchers analyzed brain blood flow, oxygen levels, and scans to understand how treatments affect the brain and body. The goal is to develop more pe…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…

This study looked at 366 people who had a brain bleed from a burst aneurysm. Researchers measured hemoglobin in the fluid around the brain and spine to see if it could predict secondary brain injury, like artery spasms or lack of blood flow. The goal is to find a better way to mo…

This study looked at 40 stroke patients with arm muscle stiffness (spasticity) who were treated with botulinum toxin (Botox). Researchers measured tiny electrical signals in the muscle to see how they change over time and whether they relate to how well the treatment works. The g…

This study used a special eye-imaging technique called adaptive optics to look at tiny blood vessels in the retina of people who recently had a stroke. Researchers compared these images to those from healthy individuals to see if the blood vessel structure differs. The goal was t…

This study looked at 15 stroke patients with a condition called cerebral amyloid angiopathy (CAA), which makes blood vessels in the brain fragile and prone to bleeding. All patients received a clot-busting drug (thrombolysis) and were checked for brain bleeding 24 hours later. Re…

This study tested two types of non-invasive brain stimulation (called paired associative stimulation) to see if they could help improve hand movement in people who had a stroke. 81 participants (60 stroke survivors and 24 healthy volunteers) took part. The main goal was to unders…

This study looked at 206 patients who had carotid artery surgery to see if the hyoid bone (a small bone in the neck) is linked to artery narrowing and stroke. Researchers used CT scans to measure the distance and position between the hyoid bone and the carotid artery. The goal wa…

This study looked at brain scans from 315 people with two types of small vessel disease: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). Researchers wanted to see if the pattern of white matter changes around the brain's fluid-filled spaces could help tell t…

This study looked at 111 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. Researchers used MRI scans to check for iron deposits in the cerebellum, a part of the brain that controls balance and coordination. The goal was to learn where …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This study looked at brain MRI scans of 122 stroke patients to see if those with a blood clot in the heart (intracardiac thrombus) had different patterns of brain damage compared to those with atrial fibrillation. Researchers analyzed the location, size, and number of stroke lesi…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This completed study followed 633 stroke or TIA survivors in France to understand why some stop taking their secondary prevention medications. Researchers looked at factors like age, beliefs about medicine, and healthcare access. The goal is to improve long-term adherence and pre…

This study looked at how well people think and remember after surgery to clear a blocked neck artery (carotid endarterectomy). About 800 patients took brain tests before and after surgery, and their results were compared to people having spine surgery. The goal was to find out ho…

This study reviewed medical records of 70 children under 18 who received clot-busting drugs or mechanical clot removal for a stroke. Researchers measured how quickly treatment was given and looked for side effects like bleeding. The goal is to better understand the safety and tim…

This study used a special light-based imaging technique called fNIRS to watch how the brain reorganizes itself in the first two months after a stroke. Ten participants who had a stroke 2-4 weeks earlier underwent standard physical and occupational therapy while researchers measur…

This study tested a small, wearable sensor (FOX HiKoB) to measure foot movement in 29 stroke survivors who have foot drop. The goal was to see if the sensor could accurately detect when the foot lifts, which could then trigger electrical stimulation to help lift the foot. The sen…

This completed pilot study tested whether giving a daily multi-nutrient drink to people who recently had an ischemic stroke is practical and acceptable. Twenty-four adults were split into two groups: one received the drink plus standard care, the other standard care alone. The ma…

This pilot study looked at how focused sound waves (shock wave therapy) reduce muscle tightness in the arm after a stroke. Twelve adults who had a stroke at least six months ago received the treatment. Researchers measured changes in muscle stiffness, nerve signals, and arm funct…

This study created a database of information from 105 stroke patients who had a procedure to remove a large blood clot from the brain. Doctors used a special wire to help guide a tube to the clot. The goal was to see if the wire alone could get the tube to the right spot. This wa…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This study tests two new monitoring techniques—long loop reflexes (F-waves) and near-infrared spectroscopy (NIRS)—to detect spinal cord ischemia early after thoracoabdominal aortic aneurysm repair. Current methods work during surgery but are too painful for awake patients afterwa…

This completed study looked at how often thinking, memory, and behavior problems happen after a stroke. Researchers tested over 1600 people, including stroke patients and healthy volunteers, using a French version of a standard cognitive battery. The goal was to better understand…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This completed study looked at 258 people with different types of cardiomyopathy (a disease of the heart muscle) to see if special imaging could predict stroke risk. Researchers used echocardiograms and MRI scans to measure blood flow in the heart and check for silent brain infar…

This study used advanced MRI scans to look at how water and brain chemicals move in the brain after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to track changes over three months. The goal was to learn more about how brain cells are affected, which …