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Balloon 'Postconditioning' may shield brain after stroke

NCT ID NCT06526429

Disease control Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a procedure called rapid local ischemic postconditioning in 25 people who had a stroke and successful clot removal. Right after reopening the blocked artery, doctors briefly inflated and deflated a balloon in the neck to temporarily stop blood flow, aiming to help the brain adapt. The main goal was to check safety and find the best dose for future studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rapid local ischemic postconditioning (balloon inflation/deflation procedure)
What this could lead to
If it works, this could point toward a simple procedure to reduce brain damage after stroke clot removal.
What could go wrong
This is a very early, small safety study with only 25 participants. The procedure may cause complications like vessel spasm or embolism, and it is not yet known if it improves outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Oct 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Presenting with symptoms and signs consistent with acute anterior circulation ischemic stroke * Pre-stroke modified Rankin Score 0-1 * Baseline National Institute of Health Stroke Scale (NIHSS) score≥6 * Endovascular treatment can be initiated (femoral puncture) within 24 hours from stroke onset (stroke onset time is defined as last known well time) * Occlusion of the intracranial internal carotid artery, or the middle cerebral artery (MCA) (M1 or M2) and is the culprit artery * Ischemic core volume is \< 70 ml, mismatch ratio is \>1.8 and mismatch volume is \>15 ml as determined by CT perfusion imaging * Embolism verified as the etiology of occluded artery and modified Thrombolysis in Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy. * Time from CT perfusion to reperfusion \< 2 hours * Informed consent signed Exclusion Criteria: * Stenosis of the proximal middle cerebral artery, internal carotid artery, or common carotid artery (≥50%) of the culprit artery * Evidence of internal carotid artery lesion that precludes the access and application of balloon guide catheter * Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or an MCA and a basilar artery occlusion) * Pre ischemic stroke within past 3 months * The expected survival time is less than 6 months, could not be followed at 90 days (such as patient with malignant tumor) * Currently pregnant, mental disease, advanced hepatic and renal insufficiency, severe heart failure * Participation in other interventional randomized clinical trials that may confound the outcome assessment of the trial * Other circumstances that the investigator considers inappropriate for this trial

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Conditions

The condition(s) this trial relates to.

brain edema ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke Brain edema Ischemic postconditioning Mechanical thrombectomy Neuroprotection

Contacts and locations

Locations

  • Shanghai Jiao Tong University Affiliated Sixth People's Hospital

    Shanghai, 200023, China

  • Shanghai Jiao Tong University Affiliated Sixth People's Hospital

    Shanghai, 200233, China

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