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Ear stimulation shows promise for rewiring Stroke-Damaged brains

NCT ID NCT07282106

Knowledge-focused Sponsor: Clinique Les Trois Soleils Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether mild electrical stimulation of the outer ear (taVNS) can change how brain regions communicate in people who had a stroke more than 6 months ago, as well as in healthy adults. Researchers used a brain-imaging technique called fNIRS to measure resting-state connectivity. The study included 84 participants and compared real stimulation to a sham (placebo) condition to see if taVNS has a specific effect on brain networks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) - mild electrical pulses to the outer ear
What this could lead to
If it works, this could point toward a non-invasive way to help rewire brain networks after stroke.
What could go wrong
This is a small, early-stage study focused on brain imaging, not on improving symptoms or function. Results may not translate to real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

84 people

The number who actually took part.

Started

Dec 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for post-stroke participant: * age 18 or older * Right-handed participant; * Hemiparesis in the chronic phase (\>6 months post-stroke) * Participant who has agreed to sign an informed consent form; * Participant who is affiliated with social security. Inclusion Criteria for healthy participant: * age 18 or older * Right-handed participant; * Participant who has agreed to sign an informed consent form; * Participant who is affiliated with social security. Exclusion Criteria for post-stroke participant: * Allergy to neoprene (the material used to make the fNIRS cap); * Hair volume preventing the cap from being put on and/or access to the scalp; * Cognitive impairment making it impossible to participate in the study; * Phasic disorders preventing understanding of instructions and effective communication; * Pregnant or breastfeeding women; * Persons under legal protection Exclusion Criteria for post-stroke participant: * Allergy to neoprene (the material used to make the fNIRS cap); * Hair volume preventing the cap from being put on and/or access to the scalp; * Pregnant or breastfeeding women; * Persons under legal protection

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic stroke patients

Contacts and locations

Locations

  • Clinique Les Trois Soleils

    Boissise-le-Roi, 77310, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.